Protein Dynamics and Flexibility by NMR Group
Group leader : Martin Blackledge
Martin Blackledge (E7 CEA)
Guillaume Bouvignies (CR2 CNRS)
Malene Ringkjøbing Jensen (CR1 CNRS)
Damien Maurin (Engineer CNRS)
Anton Abyzov (Ph.D. student)
Guillaume Communie (Postdoctoral fellow)
Elise Delaforge (Ph.D. student)
Jaka Kragelj (Ph.D. student)
Sigrid Milles (Postdoctoral fellow)
Nicola Salvi (Postdoctoral fellow)
Welcome to the web-page of the Protein Dynamics and Flexibility by NMR group at the IBS under the direction of Martin Blackledge.
The precision with which X-ray crystallography and NMR have provided structural models of biologically active and inactive conformations of countless proteins belies an easily overlooked dilemma. Proteins are inherently dynamic, exhibiting conformational freedom on timescales from picoseconds to seconds, implicating structural rearrangements that play a major role in molecular interaction; in the thermodynamic stability of functional states; in molecular recognition processes; or in allostery and molecular signalling. Static structural models afford little insight into the underlying conformational equilibrium.
NMR spectroscopy is uniquely placed to study a large number of these dynamic processes, resolving detailed and important site-specific information about motions spanning a vast range of time scales in both folded and unfolded proteins, and in both the liquid and the solid phase.
The overarching interest of our research group lies in the study of protein dynamics, developing and applying diverse experimental and analytical approaches to characterize the role of conformational flexibility in biological function on a broad range of time and length scales, from molecular recognition dynamics in folded proteins, to reorganizational dynamics of large multidomain assemblies exhibiting extensive protein disorder.
NMR, conformational flexibility, intrinsically disordered proteins, protein dynamics, protein structure determination, protein folding, functional dynamics.
M. Schwalbe, V. Ozenne, S. Bibow, M. Jaremko , L. Jaremko, M. Gajda, M.R. Jensen, J. Biernat, S. Becker, E. Mandelkow, M. Zweckstetter* and M. Blackledge*.
J. Huang, L. Warner, C. Sanchez, F. Gabel, T. Madl, C. Mackereth, M. Sattler* and M. Blackledge*.
P. Guerry, L. Salmon, L. Mollica, J.L. Ortega Roldan, P. Markwick, N. van Nuland, J.A. McCammon and M. Blackledge
V. Ozenne, R. Schneider, M. Yao, J.R. Huang, L. Salmon, M. Zweckstetter, M.R. Jensen and M. Blackledge
M. R. Jensen, G. Communie, E. A. Ribeiro, N. Martinez, A. Desfosses, L. Salmon, L. Mollica, F. Gabel, M. Jamin, S. Longhi, R. W. H. Ruigrok and M. Blackledge.
L. Salmon, J. L. Ortega-Roldan, E. Lescop, A. Licinio, N. A. J. van Nuland, M. R. Jensen* and M. Blackledge*.
L. Salmon, G. Nodet, V. Ozenne, G. Yin, M. R. Jensen, M. Zweckstetter and M. Blackledge.
M. R. Jensen*, L. Salmon, G. Nodet and M. Blackledge*.
P. R. Markwick, G. Bouvignies, L. Salmon, J. A. McCammon, M. Nilges and M. Blackledge.
L. Salmon, G. Bouvignies, P. Markwick, N. Lakomek, S. Showalter, D. W. Li, K. Walter, C. Griesinger, R. Bruschweiler and M. Blackledge.
M. Wells, H. Tidow, T. J. Rutherford, P. Markwick, M. R. Jensen, E. Mylonas, D. I. Svergun, M. Blackledge* and A. R. Fersht*.
P. Bernado, L. Blanchard, P. Timmins, D. Marion, R. Ruigrok and M. Blackledge.
We currently have open positions for Ph.D students as well as postdoctoral fellows. Please contact Dr. Martin Blackledge.