Publications LPC
Publications 2010
Kozielski F, Riaz T, DeBonis S, Koehler CJ, Kroening M, Panse I, Strozynski M, Donaldson IM and Thiede B
Proteome analysis of microtubule-associated proteins and their interacting partners from mammalian brain.
Amino Acids (2010) : 1-23
Publications 2009
Behlke-Steinert S, Touat-Todeschini L, Skoufias DA and Margolis RL
SMC5 and MMS21 are required for chromosome cohesion and mitotic progression.
Cell Cycle (2009) 8(14) : 2211-2218
Hans F, Skoufias D A, Dimitrov S and Margolis R L
Molecular distinctions between aurora A and B : A single residue change transforms aurora A into correctly localized and functional aurora B.
Molecular Biology of the Cell (2009) 20(15) : 3491-3502
Lee J, Kim JA, Barbier V, Fotedar A and Fotedar R
DNA damage triggers p21WAF1-dependent emi1 down-regulation that maintains G2 arrest.
Molecular Biology of the Cell (2009) 20(7) : 1891-1902
Popowycz F, Schneider C, DeBonis S, Skoufias DA, Kozielski F, Galmarini CM and Joseph B
Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives.
Bioorganic and Medicinal Chemistry (2009) 17(9) : 3471-3478
Tcherniuk S, van Lis R, Kozielski F and Skoufias DA
Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-l-cysteine in tumor derived cell lines.
Biochemical Pharmacology (2009) 79(6) : 864-872
Wade RH, Garcia-Saez I and Kozielski F
Structural variations in protein superfamilies : actin and tubulin.
Molecular Biotechnology (2009) 42 : 49-60
Publications 2008
Debonis S, Skoufias DA, Indorato RL, Liger F, Marquet B, Laggner C, Joseph B and Kozielski F
Structure-activity relationship of s-trityl-l-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.
Journal of Medicinal Chemistry (2008) 51(5) : 1115-1125
Kozielski F, Skoufias DA, Indorato RL, Saoudi Y, Jungblut PR, Hustoft HK, Strozynski M and Thiede B
Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5.
Proteomics (2008) 8(2) : 289-300
Publications 2007
Klein E, DeBonis S, Thiede B, Skoufias DA, Kozielski F and Lebeau L
New chemical tools for investigating human mitotic kinesin Eg5.
Bioorganic & Medicinal Chemistry (2007) 15(19) : 6474-6488
Kozielski F, DeBonis S and Skoufias DA
Screening for inhibitors of microtubule-associated motor proteins.
Methods in Molecular Medicine (2007) 137 : 189-207
Skoufias DA, Indorato RL, Lacroix F, Panopoulos A and Margolis RL
Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed.
Journal of Cell Biology (2007) 179(4) : 671-685
Publications 2006
Skoufias DA, Debonis S, Saoudi Y, Lebeau L, Crevel I, Cross R, Wade RH, Hackney D and Kozielski F
S-trityl-l-cysteine is a reversible, tight-binding inhibitor of the human kinesin eg5 that specifically blocks mitotic progression.
Journal of Biological Chemistry (2006) 281 : 17559-17569
Publications 2005
Jascur T, Brickner H, Salles Passador I, Barbier V, El Khissiin A, Fotedar A and Fotedar R
Regulation of p21WAF1/CIP1 stability by WISp39, a novel Hsp90-binding TPR protein
Molecular Cell (2005) 17(2) : 237-349
Margolis RL
Tetraploidy and tumor development.
Cancer Cell (2005) 8(5) : 353-354
Mollinari C, Kleman JP, Saoudi Y, Jablonski S, Perard J, Yen T and Margolis RL
Ablaton of PRC1 by siRNA demonstrates that telophase furrow ingression does not require a central spindle bundle in mammalian cells
Molecular Biology of the Cell (2005) 16(3) : 1043-1055
Scrittori L, Skoufias DA, Hans F, Gerson V, Sasson-Corsi P, Dimitrov D and Margolis RL
A small C-terminal sequence of Aurora B is responsible for localization and function
Molecular Biology of the Cell (2005) 16(1) : 292-305
Publications 2004
Andreassen P R, Skoufias D A and Margolis R L
Analysis of the spindle-assembly checkpoint in HeLa cells
Methods in Molecular Biology (2004) 281 : 213-26
Debonis S, Skoufias D A, Lebeau L, Lopez R, Robin G, Margolis R L, Wade R H and Kozielski F
In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities
Molecular Cancer Therapeutics (2004) 3(9) : 1079-1090
Delacour-Larose M, Molla A, Skoufias D A, Margolis R L and Dimitrov D
Distinct dynamics of aurora B and survivin during mitosis
Cell Cycle (2004) 3(11) : 1418-1426
Fotedar R, Bendjennat M and Fotedar A
Role of the p21WAF1 in the cellular response to UV.
Cell Cycle (2004) 3(2) : 134-137
Fotedar R, Bendjennat M and Fotedar A
Functional Analysis of CDK Inhibitor p21WAF1
Methods in Molecular Biology (2004) 281 : 55-72
Margolis R L
Bub1, a gatekeeper for cdc20-dependent mitotic exit
Developmental Cell (2004) 7(5) : 634-635
Pennaneach V, Barbier V, Regazzoni K, Fotedar R and Fotedar A
Rb Inhibits E2F-1-induced cell death in a LXCXE-dependent manner by active repression
Journal of Biological Chemistry (2004) 279(22) : 23376-83
Skoufias D A, Lacroix F B, Andreassen P R, Wilson L and Margolis R L
Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase
Molecular Cell (2004) 15(6) : 977-990
Publications 2003
Andreassen P R, Lohez O D and Margolis R L
G2 and spindle assembly checkpoint adaptation, and tetraploidy arrest :: Implications for intrinsic and chemically induced genomic instability
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis (2003) 532(1-2) : 245-253
Bendjennat M, Boulaire J, Jascur T, Brickner H, Barbier V, Sarasin A, Fotedar A and Fotedar R
UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair
Cell (2003) 114(5) : 599-610
Bouvier D, Vanhaverbeke C, Simorre J P, Arlaud G J, Bally I, Forge V, Margolis R L, Gans P and Kleman J P
Unusual Ca2+-calmodulin binding interactions of the microtubule-associated protein F-STOP
Biochemistry (2003) 42(39) : 11484-11493
Debonis S, Simorre J P, Crevel I, Lebeau L, Skoufias D A, Blangy A, Ebel C, Gans P, Cross R, Hackney D D, Wade R H and Kozielski F
Interaction of the mitotic inhibitor monastrol with human kinesin Eg5
Biochemistry (2003) 42(2) : 338-49
Lohez OD, Reynaud C, Borel F, Andreassen PR and Margolis RL
Arrest of mammalian fibroblasts in G1 in response to actin inhibition is dependent on retinoblastoma pocket proteins but not on p53
The Journal Of Cell Biology (2003) 161(1) : 67-77
Margolis R L, Lohez O D and Andreassen P R
G1 tetraploidy checkpoint and the suppression of tumorigenesis.
Journal of Cellular Biochemistry (2003) 88(4) : 673-83
Mollinari C, Reynaud C, Martineau-Thuillier S, Monier S, Kieffer S, Garin J, Andreassen P R, Boulet A, Goud B, Kleman J P and Margolis R L
The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression
Developmental Cell (2003) 5(2) : 295-307
Munshi A, Cannella D, Brickner H, Salles Passador I, Podust V, Fotedar R and Fotedar A
Cell Cycle-dependent Phosphorylation of the Large Subunit of Replication Factor C (RF-C) Leads to Its Dissociation from the RF-C Complex
Journal of Biological Chemistry (2003) 278(48) : 48467-73
Salles-Passador I, Munshi A, Cannella D, Pennaneach V, Koundrioukoff S, Jacquinod M, Forest E, Podust V, Fotedar A,Fotedar et, al.
Phosphorylation of the PCNA binding domain of the large subunit of replication factor C on Thr506 by cyclin-dependent kinases regulates binding to PCNA
Nucleic Acids Research (2003) 31(17) : 5202-5211
Publications 2002
Borel F, Lohez OD, Lacroix FB and Margolis RL
Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein compromised cells
Proceedings of the National Academy of Sciences (2002) 99(15) : 9819-9824
Borel F, Lacroix FB and Margolis RL
Prolonged arrest of mammalian cells at the G1/S boundary results in permanent S phase stasis
Journal of Cell Science (2002) 115(14) : 2829-2838.
Margolis RL
Checkpoints that count (Views and Commentaries)
Cell Cycle (2002) 1 : 37-38
Mollinari C, Kleman JP, Jiang W, Schoehn G, Hunter T and Margolis RL
PRC1 is a microtubule binding and bunding protein essential to maintain the late mitotic spindle midzone
Journal of Cell Biology (2002) 157(7) : 1175-86
Mollinari C, Lange B and Gonzalez C
Miranda, a protein involved in neuroblast asymmetric division, is associated with embryonic centrosomes of Drosophila melanogaster
Biology of the Cell (2002) 94(1) : 1-13
Publications 2001
Andreassen PR, Lacroix FB, Lohez OD and Margolis RL.
Neither p21(WAF1) Nor 14-3-3sigma Prevents G(2) Progression to Mitotic Catastrophe in Human Colon Carcinoma Cells after DNA Damage, But p21(WAF1) Induces Stable G(1) Arrest in Resulting Tetraploid Cells.
Cancer Research (2001) 61(20) : 7660-8
Andreassen, P. R., Lohez, O. D., Lacroix, F. B. and Margolis, R. L.
Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1.
Molecular Biology of the Cell (2001) 12(5) : 1315-28
Margolis RL
The centrosome and its mysteries. Book review of : the centrosome in cell replication nd early development
Nature Cell Biology (2001) 3 : E324
Mialhe, A., Lafanecheere, L., Treilleux, I., Peloux, N., Dumontet, C., Bremond, A., Panh, M. H., Payan, R., Wehland, J., Margolis, R. L. and Job, D.
Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis.
Cancer Research (2001) 61(13) : 5024-7
Pennaneach V, Salles-Passador I, Munshi A, Brickner H, Regazzoni K, Dick F, Dyson N, Chen T, Wang JY, Fotedar R and Fotedar A
The Large Subunit of Replication Factor C Promotes Cell Survival after DNA Damage in an LxCxE Motif- and Rb-Dependent Manner
Molecular Cell (2001) 7(4) : 715-27
Rousseau, D
EIF-4E, regulation of translation and tumor progression.
Medecine Sciences (2001) 17(3) : 336-343
Skoufias, D. A., Andreassen, P. R., Lacroix, F. B., Wilson, L. and Margolis, R. L.
Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints
Proceedings of the National Academy of Sciences U S A (2001) 98(8) : 4492-7
Publications 2000
Boulaire, J., Fotedar, A. and Fotedar, R.
The functions of the cdk-cyclin kinase inhibitor p21WAF1.
Pathological Biology (2000) 48(3) : 190-202
Chantalat L, Skoufias DA, Kleman JP, Jung B, Dideberg O and Margolis RL
Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions
Molecular Cell (2000) 6(1) : 183-189
Skoufias, D. A., Mollinari, C., Lacroix, F. B. and Margolis, R. L.
Human Survivin Is a Kinetochore-associated Passenger Protein.
Journal of Cellular Biology (2000) 151(7) : 1575-1582
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