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LEM Publications

Publications 2010

Biro A, Ling WL and Arlaud GJ
Complement protein C1q recognizes enzymatically modified low-density lipoprotein through unesterified fatty acids generated by cholesterol esterase.
Biochemistry (2010) 49(10) : 2167-2176

Gaboriaud C, Garlatti V, Chouquet A, Lunardi T, Païdassi H, Thielens NM and Arlaud GJ
C1q binds deoxyribose and heparan sulfate through neighboring sites of its recognition domain : Implications for the control of C1 activation upon recognition of non-immune targets.
Molecular Immunology (2010) 47(13) : 2255-2256

Garlatti V, Martin L, Lacroix M, Gout E, Arlaud G, Thielens N and Gaboriaud C
Structural insights into the recognition properties of human ficolins.
Journal of Innate Immunity (2010) 2 : 17-23

Gjelstrup LC, Thiel S, Kingshott P, Thielens N and Vorup-Jensen T
In-depth analysis by Biacore technology to evaluate the affinity versus avidity of the binding of the oligomeric pattern recognition molecule mannan-binding lectin.
Molecular Immunology (2010) 47(13) : 2263-2263

Gout E, Schoehn G, Fenel D, Lortat-Jacob H and Fender P
The adenovirus type 3 dodecahedron’s RGD loop comprises an HSPG binding site that influences integrin binding.
Journal of Biomedicine and Biotechnology (2010) 2010 : 541939

Gout E, Doni A, Lacroix M, Arlaud GJ, Mantovani A and Thielens NM
M-ficolin interacts with the long-chain pentraxin PTX3. A novel case of crosstalk between pattern recognition proteins ?
Molecular Immunology (2010) 47(13) : 2232-2233

Gout E, Garlatti V, Smith DF, Lacroix M, Dumestre-Pérard C, Lunardi T, Martin L, Cesbron JY, Arlaud GJ, Gaboriaud C and Thielens NM
Carbohydrate recognition properties of huma ficolins : Glycan array screening revealms the sialic acid binding specificity of M-ficolin.
Journal of Biological Chemistry (2010) 285(9) : 6612-6622

Hair PS, Gronemus JQ, Crawford KB, Salvi VP, Cunnion KM, Thielens NM, Arlaud GJ, Rawal N and Krishna NK
Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation.
Molecular Immunology (2010) 47(4) : 792-798

Jasnin M, van Eijck L, Koza MM, Peters J, Laguri C, Lortat-Jacob H and Zaccai G
Dynamics of heparan sulfate explored by neutron scattering.
Physical Chemistry Chemical Physics (2010) 12(14) : 3360-3362

Pflieger D, Przybylski C, Gonnet F, Le Caer JP, Lunardi T, Arlaud GJ and R. D
Analysis of human C1q by combined bottom-up and top-down mass spectrometry : Detailed mapping of post-translational modifications and insights into the C1r/C1s binding sites.
Molecular and Cellular Proteomics (2010) 9(4) : 593-610

Przybylski C, Gonnet F, Bonnaffe D, Hersant Y, Lortat-Jacob H and Daniel R
HABA-based ionic liquid matrices for UV-MALDI-MS analysis of heparin and heparan sulfate oligosaccharides.
Glycobiology (2010) 20(2) : 224-234

Rossi V, Bally I, Ancelet S, Xu Y, Fremeaux-Bacchi V, Vives RR, Sadir R, Thielens N and Arlaud GJ
Functional characterization of the recombinant human C1 inhibitor serpin domain : insights into heparin binding.
Journal of Immunology (2010) 184(9) : 4982-4989

Rossi V, Wang Y and Esser AF
Topology of the membrane-bound form of complement protein C9 probed by glycosylation mapping, anti-peptide antibody binding, and disulfide modification.
Molecular Immunology (2010) 47(7-8) : 1553-1560

Villegas-Mendez A, Garin MI, Pineda-Molina E, Veratti E, Bueren JA, Fender P and Lenormand JL
In vivo delivery of antigens by adenovirus dodecahedron induces cellular and humoral immune responses to elicit antitumor immunity.
Molecular Therapy (2010) 18(5) : 1046-1053

Publications 2009

Andreoletti P, Mouesca J-M, Gouet P, Jaquinod M, Capeillère-Blandin C and Jouve HM
Verdoheme formation in Proteus mirabilis catalase.
Biochimica et Biophysica Acta (BBA) - General Subjects (2009) 1790(8) : 741-753

Baleux F, Loureiro-Morais L, Hersant Y, Clayette P, Arenzana-Seisdedos F, Bonnaffe D and Lortat-Jacob H
A synthetic CD4-heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry.
Nature Chemical Biology (2009) 5(10) : 743-748

Bally I, Rossi V, Lunardi T, Thielens NM, Gaboriaud C and Arlaud GJ
Identification of the C1q-binding Sites of Human C1r and C1s : a refined three-dimensional model of the C1 complex of complement.
Journal of Biological Chemistry (2009) 284(29) : 19340-19348

Biro A and Arlaud GJ
C1 activation by enzymatically modified low-density lipoprotein involves free lipids released by cholesterol esterase treatment.
Molecular Immunology (2009) 46(14) : 2845-2845

Duchardt F, Ruttekolk IR, Verdurmen WP, Lortat-Jacob H, Burck J, Hufnagel H, Fischer R, van den Heuvel M, Lowik DW, Vuister GW, Ulrich A, de Waard M and Brock R
A cell-penetrating peptide derived from human lactoferrin with conformation-dependent uptake efficiency.
Journal of Biological Chemistry (2009) 284(52) : 36099-36108

Erlich P, Dumestre-Pérard C, Ling WL, Lemaire-Vieille C, Arlaud G, Gagnon J and Cesbron J-Y
Prion protein oligomers and C1q recognition.
Molecular Immunology (2009) 46(14) : 2837-2837

Gout E, Garlatti V, Smith D, Lacroix M, Lunardi T, Arlaud GJ, Gaboriaud C and Thielens NM
Carbohydrate recognition properties of human ficolins : Glycan array screening provides insights into the sialic acid binding specificity of M-ficolin.
Molecular Immunology (2009) 46(14) : 2819-2819

Gras S, Saulquin X, Reiser J-B, Debeaupuis E, Echasserieau K, Kissenpfennig A, Legoux F, Chouquet A, Le Gorrec M, Machillot P, Neveu B, Thielens N, Malissen B, Bonneville M and Housset D
Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope.
Journal of Immunology (2009) 183(1) : 430-437

Lacroix M, Dumestre-Perard C, Schoehn G, Houen G, Cesbron JY, Arlaud GJ and Thielens NM
Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin.
Journal of Immunology (2009) 182(1) : 456-465

Lortat-Jacob H
The molecular basis and functional implications of chemokine interactions with heparan sulphate.
Current Opinion in Structural Biology (2009) 19 : 543-548

Ma YJ, Doni A, Hummelshoj T, Honore C, Bastone A, Mantovani A, Thielens NM and Garred P
Synergy between ficolin-2 and PTX3 boost innate immune recognition and complement deposition.
Journal of Biological Chemistry (2009) 284(41) : 28263-28275

Païdassi H, Tacnet-Delorme P, Arlaud GJ and Frachet P
How phagocytes track down and respond to apoptotic cells.
Critical Reviews in Immunology (2009) 29(2) : 111-130

Rossi V, Bally I, Xu Y, Frémeaux-Bacchi V, Vives R, Ancelet S and Arlaud GJ
Expression and functional characterization of the serpin domain of human C1 inhibitor.
Molecular Immunology (2009) 46(14) : 2863-2863

Scarpellini A, Germack R, Lortat-Jacob H, Muramatsu T, Billett E, Johnson T and Verderio EA
Heparan sulfate proteoglycans are receptors for the cell-surface trafficking and biological activity of transglutaminase-2.
Journal of the Biological Chemistry (2009) 284(27) : 18411-18423

Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, Mennechet F, Schoehn G, Lortat-Jacob H, Dreja H, Ibanes S, Kalatzis V, Wang JP, Finberg RW, Cusack S and Kremer EJ
The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution.
PLoS Pathogens (2009) 5(1) : e1000277

Seiradake E, Philipsborn ACV, Henry M, Lortat-Jacob H, Jamin M, Hemrika W, Bastmeyer M, Cusack S and McCarthy AA
Structure and functional relevance of the Slit2 homodimerization domain.
Embo Reports (2009) 10(7) : 736-741

Siqueira-Silva J, Yeda FP, Favier AL, Mezin P, Silva ML, Barrella KM, Mehnert DU, Fender P and Harsi CM
Infection kinetics of human adenovirus serotype 41 in HEK 293 cells.
Memoris do Instituto Oswaldo Cruz (2009) 104(5) : 736-744

Sulka B, Lortat-Jacob H, Terreux R, Letourneur F and Rousselle P
Tyrosine dephosphorylation of the syndecan-1 PDZ binding domain regulates syntenin-1 recruitment.
Journal of Biological Chemistry (2009) 284(16) : 10659-10671

Tristan A, Benito Y, Montserret R, Boisset S, Dusserre E, Penin F, Ruggiero F, Etienne J, Lortat-Jacob H, Lina G, Bowden MG and Vandenesch F
The signal peptide of Staphylococcus aureus panton valentine leukocidin LukS component mediates increased adhesion to heparan sulfates.
PLoS ONE (2009) 4(4) : e5042

Publications 2008

Adam E, Sarrazin S, Landolfi C, Motte V, Lortat-Jacob H, Lassalle P and Delehedde M
Efficient long-term and high-yielded production of a recombinant proteoglycan in eukaryotic HEK293 cells using a membrane-based bioreactor.
Biochemical and Biophysical Research Communications (2008) 369(2) : 297-302

Bally I, Rossi V, Thielens N, Gaboriaud C and Arlaud G
Identification of the C1q binding sites of C1r and C1s : A refined 3D model of the C1 complex.
Molecular Immunology (2008) 45(16) : 4097-4097

Biro A and Arlaud GJ
C1q recognizes the lipid component of enzymatically modified low-density lipoprotein.
Molecular Immunology (2008) 45(16) : 4140-4140

Crublet E, Andrieu JP, Vives RR and Lortat-Jacob H
The HIV-1 envelope glycoprotein gp120 features four heparan sulfate binding domains, including the co-receptor binding site.
Journal of Biological Chemistry (2008) 283(22) : 15193-15200

Erlich P, Cesbron JY, Lemaire-Vieille C, Curt A, Andrieu JP, Schoehn G, Jamin M and Gagnon J
PrP N-terminal domain triggers PrPSc-like aggregation of Dpl.
Biochemical and Biophysical Research Communications (2008) 365(3) : 478-483

Fender P, Schoehn G, Perron-Sierra F, Tucker GC and Lortat-Jacob H
Adenovirus dodecahedron cell attachment and entry are mediated by heparan sulfate and integrins and vary along the cell cycle.
Virology (2008) 371(1) : 155-164

Kerr FK, Thomas AR, Wijeyewickrema LC, Whisstock JC, Boyd SE, Kaiserman D, Matthews AY, Bird PI, Thielens NM, Rossi V and Pike RN
Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor.
Molecular Immunology (2008) 45(3) : 670-677

Lacroix M, Dumestre-Pérard C, Houen G, Arlaud G and Thielens N
Residue Lys57 in the collagen-like region of human l-ficolin and its counterpart Lys47 in H-ficolin play an essential role in interaction with the MASPs and the collectin co-receptor calreticulin.
Molecular Immunology (2008) 45(16) : 4134-4134

Laguri C, Arenzana-Seisdedos F and Lortat-Jacob H
Relationships between glycosaminoglycan and receptor binding sites in chemokines-the CXCL12 example.
Carbohydrate research (2008) 343(12) : 2018-2023

Ma YJ, Doni A, Honoré C, Mantovani A, Thielens NM and Garred P
Biochemical and functional characterisation of the interaction between pentraxin 3 and the ficolins.
Molecular Immunology (2008) 45(16) : 4135-4135

Mercey E, Sadir R, Maillart E, Roget A, Baleux F, Lortat-Jacob H and Livache T
Polypyrrole oligosaccharide array and surface plasmon resonance imaging for the measurement of glycosaminoglycan binding interactions.
Analytical Chemistry (2008) 80(9) : 3476-3482

Pagh R, Duus K, Laursen I, Hansen PR, Mangor J, Thielens NM, Arlaud GJ, Kongerslev L, Hojrup P and Houen G
The chaperone and potential mannan-binding lectin (MBL) co-receptor calreticulin interacts with MBL through the binding site for MBL-associated serine proteases.
Febs Journal (2008) 275(3) : 515-526

Paidassi H, Tacnet-Delorme P, Garlatti V, Darnault C, Ghebrehiwet B, Gaboriaud C, Arlaud GJ and Frachet P
C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition.
Journal of Immunology (2008) 180(4) : 2329-2338

Païdassi H, Tacnet-Delorme P, Lunardi T, Arlaud GJ, Thielens NM and Frachet P
The lectin-like activity of human C1q and its implication in DNA and apoptotic cell recognition.
FEBS Letters (2008) 582(20) : 3111-3116

Ram N, Aroui S, Jaumain E, Bichraoui H, Mabrouk K, Ronjat M, Lortat-Jacob H and De Waard M
Direct peptide interaction with surface glycosaminoglycans contributes to the cell penetration of maurocalcine.
Journal of Biological Chemistry (2008) 283(35) : 24274-24284

Rueda P, Balabanian K, Lagane B, Staropoli I, Chow K, Levoye A, Laguri C, Sadir R, Delaunay T, Izquierdo E, Pablos JL, Lendinez E, Caruz A, Franco D, Baleux F, Lortat-Jacob H and Arenzana-Seisdedos F
The CXCL12gamma chemokine displays unprecedented structural and functional properties that make it a paradigm of chemoattractant proteins.
PLoS ONE (2008) 3(7) : e2543

Sorensen HP, Vives RR, Manetopoulos C, Albrechtsen R, Lydolph MC, Jacobsen J, Couchman JR and Wewer UM
Heparan sulfate regulates ADAM12 through a molecular switch mechanism.
Journal of the Biological Chemistry (2008) 283(46) : 31920-31932

Tacnet P, Cheong EC, Goeltz P, Ghebrehiwet B, Arlaud GJ, Liu XY and Lesieur C
Trimeric reassembly of the globular domain of human C1q.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics (2008) 1784(3) : 518-529

Teillet F, Gaboriaud C, Lacroix M, Martin L, Arlaud GJ and Thielens NM
Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins.
Journal of Biological Chemistry (2008) 283(37) : 25715-25724

Wijeyewickrema LC, Quinsey N, Thielens N, Boyd SE, Matthews AY, Kaiserman D, Bird PI and Pike RN
Determination of the substrate specificity of the MASP-1 protease of the complement pathway provides initial insights into potential physiological roles.
Molecular Immunology (2008) 45(16) : 4136-4136

Publications 2007

Arlaud GJ, Barlow PN, Gaboriaud C, Gros P and Narayana SVL
Deciphering complement mechanisms : The contributions of structural biology.
Molecular Immunology (2007) 44(16) : 3809-3822

Biro A, Rovo Z, Papp D, Cervenak L, Varga L, Fust G, Thielens NM, Arlaud GJ and Prohaszka Z
Studies on the interactions between C-reactive protein and complement proteins.
Immunology (2007) 121(1) : 40-50

Biro A, Thielens NM, Cervenak L, Prohaszka Z, Fust G and Arlaud GJ
Modified low density lipoproteins differentially bind and activate the C1 complex of complement.
Molecular Immunology (2007) 44(6) : 1169-1177

Csomor E, Bajtay Z, Sandor N, Kristof K, Arlaud GJ, Thiel S and Erdei A
Complement protein C1q induces maturation of human dendritic cells.
Molecular Immunology (2007) 44(13) : 3389-3397

Dumestre-Perard C, Osmundson J, Lemaire-Vieille C, Thielens N, Grives A, Favier B, Csopaki F, Jamin M, Gagnon J and Cesbron JY
Activation of classical pathway of complement cascade by soluble oligomers of prion.
Cellular Microbiology (2007) 9(12) : 2870-2879

Dycke C, Bougault C, Gaillard J, Andrieu JP, Pantopoulos K and Moulis JM
Human iron regulatory protein 2 is easily cleaved in its specific domain : consequences for the haem binding properties of the protein.
Biochemical Journal (2007) 408(3) : 429-439

Gaboriaud C, Teillet F, Gregory LA, Thielens NM and Arlaud GJ
Assembly of C1 and the MBL- and ficolin-MASP complexes : Structural insights.
Immunobiology (2007) 212(4-5) : 279-288

Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Endo Y, Fujita T, Fontecilla-Camps JC, Arlaud GJ, Thielens NM and Gaboriaud C
Structural insights into the innate immune recognition specificities of L- and H-ficolins.
Embo Journal (2007) 26(2) : 623-633

Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Fujita T, Fontecilla-Camps JC, Arlaud GJ, Thielens NM and Gaboriaud C
The crystal structures of the binding domains of L- and H-ficolins provide insight into their recognition versatility.
Molecular Immunology (2007) 44(1-3) : 175-751

Garlatti V, Martin L, Gout E, Reiser JB, Fujita T, Arlaud GJ, Thielens NM and Gaboriaud C
Innate immune sensing : Ligand recognition by M-ficolin is subject to a pH-dependent conformational switch.
Molecular Immunology (2007) 44(16) : 3928-3929

Garlatti V, Martin L, Gout E, Reiser JB, Fujita T, Arlaud GJ, Thielens NM and Gaboriaud C
Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch.
Journal of Biological Chemistry (2007) 282(49) : 35814-35820

Hummelshoj T, Thielens NM, Madsen HO, Arlaud GJ, Sim RB and Garred P
Molecular organization of human Ficolin-2.
Molecular Immunology (2007) 44(4) : 401-411

Imberty A, Lortat-Jacob H and Perez S
Structural view of glycosaminoglycan-protein interactions.
Carbohydrate Research (2007) 342(3-4) : 430-439

Laguri C, Sadir R, Rueda P, Baleux F, Gans P, Arenzana-Seisdedos F and Lortat-Jacob H
The novel CXCL12gamma isoform encodes an unstructured cationic domain which regulates bioactivity and interaction with both glycosaminoglycans and CXCR4.
PLoS ONE (2007) 2(10) : e1110

Martelli A, Salin B, Dycke C, Louwagie M, Andrieu JP, Richaud P and Moulis JM
Folding and turnover of human iron regulatory protein 1 depend on its subcellular localization.
Febs Journal (2007) 274(4) : 1083-1092

Morlot C, Thielens NM, Ravelli RB, Hemrika W, Romijn RA, Gros P, Cusack S and McCarthy AA
Structural insights into the Slit-Robo complex.
Proceedings of the National Academy of Sciences USA (2007) 104(38) : 14923-14928

Paidassi H, Tacnet-Delorme P, Garlatti V, Darnault C, Ghebrehiwet B, Gaboriaud C, Arlaud GJ and Frachet P
C1q binds phosphatidylserine and likely acts as an early bridging molecule in apoptotic cell recognition and clearance.
Molecular Immunology (2007) 44(1-3) : 225-226

Reina JJ, Sattin S, Invernizzi D, Mari S, Martinez-Prats L, Tabarani G, Fieschi F, Delgado R, Nieto PM, Rojo J and Bernardi A
1,2-Mannobioside mimic : synthesis, DC-SIGN interaction by NMR and docking, and antiviral activity.
ChemMedChem (2007) 2(7) : 1030-1036

Teillet F, Gaboriaud C, Martin L, Lacroix M, Ogbi S, Fontecilla-Camps JC, Arlaud GJ and Thielens NM
The CUB1-EGF-CUB2 interaction domain of human MBL-associated serine protease-3 : X-ray structure and binding sites for MBL and ficolins.
Molecular Immunology (2007) 44(1-3) : 249

Teillet F, Lacroix M, Thiel S, Weilguny D, Agger T, Arlaud GJ and Thielens NM
Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases : the essential role of lys55.
Journal of Immunology (2007) 178(9) : 5710-5716

Publications 2006

de Rosny E, de Groot A, Jullian-Binard C, Gaillard J, Borel F, Pebay-Peyroula E, Fontecilla-Camps JC and Jouve HM
Drosophila nuclear receptor E75 is a thiolate hemoprotein.
Biochemistry (2006) 45(32) : 9727-9734

Fuschiotti P, Fender P, Schoehn G and Conway JF
Development of the dodecahedral penton particle from Adenovirus 3 for therapeutic application.
Journal of General Virology (2006) 87(10) : 2901-2905

Fuschiotti P, Schoehn G, Fender P, Fabry CM, Hewat EA, Chroboczek J, Ruigrok RW and Conway JF
Structure of the dodecahedral penton particle from human adenovirus type 3.
Journal of Molecular Biology (2006) 356(2) : 510-520

Garcel A, Gout E, Timmins J, Chroboczek J and Fender P
Protein transduction into human cells by adenovirus dodecahedron using WW domains as universal adaptors.
Journal of Gene Medicine (2006) 8(4) : 524-531

Horner O, Oddou JL, Mouesca JM and Jouve HM
Mossbauer identification of a protonated ferryl species in catalase from Proteus mirabilis : Density functional calculations on related models.
Journal of Inorganic Biochemistry (2006) 100(4) : 477-479

Hummelshoj T, Thielens NM, Madsen HO, Arlaud GJ, Sim RB and Garred P
Molecular organization of human Ficolin-2.
Molecular Immunology (2006) 44(4) : 401-411

Lortat-Jacob H
Interferon and heparan sulphate.
Biochemical Society Transactions (2006) 34(Part 3) : 461-464

McGrath FD, Brouwer MC, Arlaud GJ, Daha MR, Hack CE and Roos A
Evidence that complement protein C1q interacts with C-reactive protein through its globular head region.
Journal of Immunology (2006) 176(5) : 2950-2957

Perez Sanchez H, Tatarenko K, Nigen M, Pavlov G, Imberty A, Lortat-Jacob H, De La Torre JG and Ebel C
Organization of human interferon ?-heparin complexes from solution properties and hydrodynamics.
Biochemistry (2006) 45(44) : 13227-13238

Renault F, Chabriere E, Andrieu J-P, Dublet B, Masson P and Rochu D
Tandem purification of two HDL-associated partner proteins in human plasma, paraoxonase (PON1) and phosphate binding protein (HPBP) using hydroxyapatite chromatography.
Journal of Chromatography B Analytical Technologies in the Biomedical Life Science (2006) 836(1-2) : 15-21

Sarrazin S, Adam E, Lyon M, Depontieu F, Motte V, Landolfi C, Lortat-Jacob H, Bechard D, Lassalle P and Delehedde M
Endocan or endothelial cell specific molecule-1 (ESM-1) : A potential novel endothelial cell marker and a new target for cancer therapy.
Biochim Biophys Acta-Reviews on cancer (2006) 1765(1) : 25-37

Tabarani G, Reina JJ, Ebel C, Vives C, Lortat-Jacob H, Rojo J and Fieschi F
Mannose hyperbranched dendritic polymers interact with clustered organization of DC-SIGN and inhibit gp120 binding.
FEBS Letters (2006) 580(10) : 2402-2408

Van den Brandt B, Glattli H, Grillo I, Hautle P, Jouve H, Kohlbrecher J, Konter JA, Leymarie E, Mango S, May R, Michels A, Stuhrmann H and Zimmer O
Time-resolved nuclear spin-dependent small-angle neutron scattering from polarised proton domains in deuterated solutions.
European Physical Journal B (2006) 49 : 157-165

Vives RR, Lortat-Jacob H and Fender P
Heparan sulphate proteoglycans and viral vectors : ally or foe ?
Current Gene Therapy (2006) 6(1) : 35-44

Publications 2005

Bally I, Rossi V, Thielens N, Gaboriaud C and Arlaud GJ
Functional role of the linker between the complement control protein modules of complement protease C1s.
Journal of Immunology (2005) 175(7) : 4536-4542

Barbouche R, Lortat-Jacob H, Jones IM and Fenouillet E
Glycosaminoglycans and protein disulfide isomerase-mediated reduction of HIV Env
Molecular Pharmacology (2005) 67(4) : 1111-1118

Blanquet-Grossard F, Thielens NM, Vendrely C, Jamin M and Arlaud GJ
Complement protein C1q recognizes a conformationally modified form of the prion protein
Biochemistry (2005) 44(11) : 4349-4356

Delehedde M, Lortat-Jacob H, Gallagher JB, D., Lequien S and Lassalle P
Proteoglycan involvement in inflammatory diseases. New developments in GAG-based therapies.
Medicinal Chemistry Reviews (2005) 2(4) : 345-357

Dura MA, Receveur-Brechot V, Andrieu JP, Ebel C, Schoehn G, Roussel A and Franzetti B
Characterization of a TET-like Aminopeptidase Complex from the Hyperthermophilic Archaeon Pyrococcus horikoshii
Biochemistry (2005) 44(9) : 3477-3486

Fender P, Boussaid A, Mezin P and Chroboczek J
Synthesis, cellular localization, and quantification of penton-dodecahedron in serotype 3 adenovirus-infected cells.
Virology (2005) 340(2) : 167-173

Groeneveld TW, Oroszlan M, Owens RT, Faber-Krol MC, Bakker AC, Arlaud GJ, McQuillan DJ, Kishore U, Daha MR and Roos A
Interactions of the extracellular matrix proteoglycans decorin and biglycan with C1q and collectins.
J Immunol (2005) 175(7) : 4715-4723

Kostlanova N, Mitchell EP, Lortat-Jacob H, Oscarson S, Lahmann M, Gilboa-Garber N, Chambat G, Wimmerova M and Imberty A
The fucose-binding lectin from Ralstonia solanacearum : new type of b-propeller architecture by oligomerisation and interaction with fucoside, fucosyllactose and plant xyloglucan.
Journal of Biological Chemistry (2005) 280(30) : 27839-27849

Lortat-Jacob H, Fender P and Vives RR
Virus et héparane sulfate : des mécanismes d’adsorption cellulaire à l’entrée virale.
Virologie (2005) 9 : 315-325

Mahot S, Fender P, Vives RR, Caron C, Perrissin M, Gruffat H, Sergeant A and Drouet E
Cellular uptake of the EBV transcription factor EB1/Zta
Virus Research (2005) 110(1-2) : 187-193

Mitraki A and van Raaij MJ
Folding of beta-structured fibrous proteins and self-assembling peptides
Methods In Molecular Biology (Clifton, N.J.) (2005) 300 : 125-140

Papanikolopoulou K, Schoehn G, Forge V, Forsyth VT, Riekel C, Hernandez JF, Ruigrok RW and Mitraki A
Amyloid fibril frmation from sequences of a natural beta-structured fibrous protein, the adenovirus fiber
Journal of Biological Chemistry (2005) 280(4) : 2481 - 2490

Rossi V, Teillet F, Thielens NM, Bally I and Arlaud GJ
Functional characterization of complement proteases C1s/mannan-binding lectin-associated serine protease-2 (MASP-2) chimeras reveals the higher C4 recognition efficacy of the MASP-2 complement control protein modules.
Journal of Biological Chemistry (2005) 280(51) : 41811-41818

Sarrazin S, Bonnaffe D, Lubineau A and Lortat-Jacob H
Heparan sulfate mimicry : A synthetic glycoconjugate that recognizes the heparin-binding domain of IFNgamma inhibits the cytokine activity.
Journal of Biological Chemistry (2005) 208(45) : 37558-37564

Tissot B, Gonnet F, Iborra A, Berthou C, Thielens N, Arlaud GJ and Daniel R
Mass spectrometry analysis of the oligomeric C1q protein reveals the B chain as the target of trypsin cleavage and interaction with fucoidan
Biochemistry (2005) 44(7) : 2602-2609

Teillet F, Dublet B, Andrieu JP, Gaboriaud C, Arlaud GJ and Thielens NM
The two major oligomeric forms of human mannan-binding lectin : chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases
Journal of Immunology (2005) 174(5) : 2870-2877

Vives RR, Imberty A, Sattentau QJ and Lortat-Jacob H
Heparan sulfate targets the HIV-1 envelope glycoprotein gp120 coreceptor binding site
Journal of Biological Chemistry (2005) 280(22) : 21353-21357

Publications 2004

Andreoletti P, Pernoud A, Sainz G, Gouet P and Jouve H M
Structural studies of Proteus mirabilis catalase in its ground state, oxidized state and in complex with formic acid (vol D59, pg 2163, 2003).
Acta Crystallographica Section D Biological Crystallography (2004) 60 Part 3 : 617

Gaboriaud C, Thielens N M, Gregory L A, Rossi V, Fontecilla-Camps J C and Arlaud G J
Structure and activation of the C1 complex of complement : unraveling the puzzle
Trends in Immunology (2004) 25(7) : 368-373

Gregory L, Thielens N, Matsushita M, Sorensen R, Arlaud G, Fontecilla-Camps J and Gaboriaud C
The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin.
Journal of Biological Chemistry (2004) 279(28) : 29391 - 7

Kishore U, Gaboriaud C, Waters P, Shrive a K, Greenhough T J, Reid K B M, Sim R B and Arlaud G J
C1q and tumor necrosis factor superfamily : modularity and versatility
Trends in Immunology (2004) 25(10) : 551-561

Lubineau A, Lortat Jacob H, Gavard O, Sarrazin S and Bonnaffé D
Synthesis of heparan sulfate neoglycoconjugate mimetics that bind IFN-g in the nanomolar range
Chemistry - A European Journal (2004) 10 : 4265-4282

Papanikolopoulou K, Forge V, Goeltz P and Mitraki A
Formation of highly stable chimeric trimers by fusion of an adenovirus fiber shaft fragment with the foldon domain of bacteriophage t4 fibritin
Journal of Biological Chemistry (2004) 279(10) : 8991-8

Papanikolopoulou K, Teixeira S, Belrhali H, Forsyth V T, Mitraki A and Van Raaij M J
Adenovirus fibre shaft sequences fold into the native triple beta-spiral fold when N-terminally fused to the bacteriophage T4 fibritin foldon trimerisation motif
Journal of Molecular Biology (2004) 342(1) : 219-22

Ricard Blum S, Feraud O, Lortat Jacob H, Rencurosi A, Fukai N, Dkhissi F, Vittet D, Imberty A, Olsen B R and van der Rest M
Characterization of endostatin binding to heparin and heparan sulfate by surface plasmon resonance and molecular modeling : role of divalent cations.
Journal of Biological Chemistry (2004) 279(4) : 2927-36

Sadir R, Imberty A, Baleux F and Lortat Jacob H
Heparan sulfate / heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV
Journal of Biological Chemistry (2004) 279(42) : 43854-43860

Thielens N and Arlaud GJ
L’immunité innée, première ligne de défense contre l’infection
Réalités pédiatriques (2004) 92 : 17-22

van den Brandt B, Glattli H, Grillo I, Hautle P, Jouve H, Kohlbrecher J, Konter JA, Leymarie E, Mango S and May R
An experimental approach to the dynamics of nuclear polarisation
Nuclear Instruments and Methods in Physics Research Section A : Accelerators, Spectrometers, Detectors and Associated Equipment (2004) 526(1-2) : 81-90

van Raaij MJ and Mitraki A
Beta-structured viral fibres : assembly, structure and implications for materials design
Current Opinion in Solid State and Materials Science (2004) 8(2) : 151-156

Vanhaverbeke C, Simorre J P, Sadir S, Gans P and Lortat Jacob H
NMR characterisation of the interaction between the C-terminal domain of Interferon-g and heparin-derived oligosaccharides
Biochemical Journal (2004) 384(1) : 93-99

Vives R R, Crublet E, Andrieu J P, Gagnon J, Rousselle P and Lortat-Jacob H
A novel strategy for defining critical amino acid residues involved in protein/glycosaminoglycan interactions. Journal of Biological Chemistry (2004) 279(52) : 54327-33

Vives R R, Lortat-Jacob H, Chroboczek J and Fender P
Heparan sulfate proteoglycan mediates the selective attachment and internalization of serotype 3 human adenovirus dodecahedron
Virology (2004) 321(2) : 332-340

Zundel S, Cseh S, Lacroix M, Dahl M R, Matsushita M, Andrieu J P, Schwaeble W J, Jensenius J C, Fujita T, Arlaud G J and Thielens N M
Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2
Journal of Immunology (2004) 172(7) : 4342-50

Publications 2003

Andreoletti P, Pernoud A, Sainz G, Gouet P and Jouve H M
Structural studies of Proteus mirabilis catalase in its ground state, oxidized state and in complex with formic acid
Acta Crystallographica D Biological Crystallography (2003) 59(Pt 12) : 2163-8

Andreoletti P, Sainz G, Jaquinod M, Gagnon J and Jouve H M
High-resolution structure and biochemical properties of a recombinant Proteus mirabilis catalase depleted in iron
Proteins (2003) 50(2) : 261-71

Arlaud GJ, Rossi V and Gaboriaud C
Complement component C1s in Handbook of proteolytic enzymes, 2^nd edition (2003) vol. 2, édité par Barrett A J, Rawlings N D and Woessner J F Academic Press pp. 1620-1622

Arlaud GJ, Thielens N and Gaboriaud C
Complement component C1r in Handbook of proteolytic enzymes, 2^nd edition (2003) vol. 2, édité par Barrett A J, Rawlings N D and Woessner J F Academic Press pp. 1617-1620

Bernocco S, Steiglitz B M, Svergun D I, Petoukhov M V, Ruggiero F, Ricard Blum S, Ebel C, Geourjon C, Deleage G, Font B, Eichenberger D, Greenspan D S and Hulmes D J
Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein
Journal of Biological Chemistry (2003) 278(9) : 7199-205

Bouvier D, Vanhaverbeke C, Simorre J P, Arlaud G J, Bally I, Forge V, Margolis R L, Gans P and Kleman J P
Unusual Ca2+-calmodulin binding interactions of the microtubule-associated protein F-STOP
Biochemistry (2003) 42(39) : 11484-11493

Brandt B v d, Glattli H, Grillo I, Hautle P, Jouve H, Kohlbrecher J, Konter J A, Leymarie E, Mango S and May R P
Neutron scattering from polarised proton domains
Physica B : Condensed Matter (2003) 335(1-4) : 193-195

Gaboriaud C, Juanhuix J, Gruez A, Lacroix M, Darnault C, Pignol D, Verger D, Fontecilla Camps J C and Arlaud G J
The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties
Journal of Biological Chemistry (2003) 278(47) : 46974-82

Gregory L A, Thielens N M, Arlaud G J, Fontecilla-Camps J C and Gaboriaud C
X-ray Structure of the Ca2+-binding Interaction Domain of C1s : Insights into the assembly of the C1 complex of complement
The Journal Of Biological Chemistry (2003) 278(34) : 32157-32164

Lozach P Y, Lortat Jacob H, de Lacroix de Lavalette A, Staropoli I, Foung S, Amara A, Houles C, Fieschi F, Schwartz O, Virelizier J L, Arenzana Seisdedos F and Altmeyer R
DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2
Journal of Biological Chemistry (2003) 278(22) : 20358-66

Moller-Kristensen M, Jensenius J C, Jensen L, Thielens N, Rossi V, Arlaud G and Thiel S
Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals
Journal of Immunological Methods (2003) 282(1-2 SU -) : 159-167

Nanao M, Ricard-Blum S, Di Guilmi A M, LeMaire D, Lascoux D, Chabert J, Attree I and Dessen A
Type III secretion proteins PcrV and PcrG from Pseudomonas aeruginosa form a 1:1 complex through high affinity interactions
BMC Microbiology (2003) 3 : 21

Okamoto O, Bachy S, Odenthal U, Bernaud J, Rigal D, Lortat Jacob H, Smyth N and Rousselle P
Normal human keratinocytes bind to the alpha3LG4/5 domain of unprocessed laminin-5 through the receptor syndecan-1
Journal of Biological Chemistry (2003) 278(45) : 44168-77

Ricard Blum S
Implication des matricryptines issues des collagenes non fibrillaires, de MMP-2 et de SPARC dans le controle de l’angiogenese
Journal de la Société de Biologie (2003) 197(1) : 41-4

Timmins J, Schoehn G, Ricard Blum S, Scianimanico S, Vernet T, Ruigrok R W and Weissenhorn W
Ebola virus matrix protein VP40 interaction with human cellular factors Tsg101 and Nedd4
Journal of Molecular Biology (2003) 326(2) : 493-502

Varga L, Szilagyi K, Lorincz Z, Berrens L, Thiel S, Zavodszky P, Daha M, Thielens N, Arlaud G and Nagy K
Studies on the mechanisms of allergen-induced activation of the classical and lectin pathways of complement
Molecular Immunology (2003) 39(14) : 839-346

Vella F, Thielens N M, Bersch B, Arlaud G J and Frachet P
A recombinant chimeric epidermal growth factor-like module with high binding affinity for integrins
The Journal Of Biological Chemistry (2003) 278(22) : 19834-19843

Publications 2002

Arlaud GJ, Gaboriaud C, Garnier G, Circolo A, Thielens NM, Budayova-Spano M, Fontecilla-Camps JC and Volanakis JE
Structure, function and molecular genetics of human and murine C1r
Immunobiology (2002) 205(4-5) : 365-382

Arlaud G J, Gaboriaud C, Thielens N M and Rossi V
Structural biology of the C1.
Biochemical Society Transaction (2002) 30(6) : 1001-1006

Arlaud GJ, Gaboriaud C, Thielens NM, Budayova-Spano M, Rossi V and Fontecilla-Camps JC
Structural biology of the C1 complex of complement unveils the mechanisms of its activation and proteolytic activity
Molecular Immunology (2002) 39(7-8) : 383-394

Budayova-Spano M, Grabarse W, Thielens NM, Hillen H, Lacroix M, Schmidt M, Fontecilla-Camps JC, Arlaud GJ and Gaboriaud C
Monomeric structures of the zymogen and active catalytic domain of complement protease c1r. Further insights into the c1 activation mechanism
Structure (Camb) (2002) 10(11) : 1509-19

Budayova-Spano M, Lacroix M, Thielens NM, Arlaud GJ, Fontecilla-Camps JC and Gaboriaud C
The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex
Embo Journal (2002) 21(3) : 231-9

Buisson M, Hernandez JF, Lascoux D, Schoehn G, Forest E, Arlaud G, Seigneurin JM, Ruigrok RW and Burmeister WP
The crystal structure of the epstein-barr virus protease shows rearrangement of the processed C terminus
Journal of Molecular Biology (2002) 324(1) : 89-103

Cseh S, Vera L, Matsushita M, Fujita T, Arlaud GJ and Thielens NM
Characterization of the interaction between L-ficolin/p35 and mannan- binding lectin-associated serine proteases-1 and -2
Journal of Immunology (2002) 169(10) : 5735-43

Dumestre-Perard C, Ponard D, Arlaud G J, Monnier N, Sim R B and Colomb M G
Evaluation and clinical interest of mannan binding lectin function in human plasma.
Molecular Immunology (2002) 39(7-8) : 465-73

Mitraki A, Miller S and van Raaij M J
Review : conformation and folding of novel Beta-structural elements in viral fiber proteins : the triple Beta-spiral and triple Beta-helix.
Journal of Structural Biology (2002) 137(1-2) : 236-47

Thielens NM, Tacnet-Delorme P and Arlaud GJ
Interaction of C1q and mannan-binding lectin with viruses
Immunobiology (2002) 205(4-5) : 563-574

van den Brnadt B, Glattli H, Grillo I, Hautle P, Jouve H, Kohlbrecher J, Konter J A, Leymarie E, Mango S, May R P, Stuhrmann H P and Zimmer O
Neutron scattering from polarised proton domains.
Europhysics Letters (2002) 59(1) : 62-67

Publications 2001

Amara, P., Andreoletti, P., Jouve, H. M. and Field, M. J.
Ligand diffusion in the catalase from Proteus mirabilis : A molecular dynamics study.
Protein Science (2001) 10(10) : 1927-1935

Andreoletti P, Franzetti B, Nussaume L, Andrieu JP, Gagnon J, Luche S, Rabilloud T and Jouve H
Comparison of the PR mutant with the wild-type strain of Proteus mirabilis brings insight into peroxide resistance factors and regulation of catalase expression
Canadian Journal of Microbiology (2001) 47(2) : 130-138

Andreoletti P, Gambarelli S, Sainz G, Stojanoff V, White C, Desfonds G, Gagnon J, Gaillard J and Jouve HM
Formation of a tyrosyl radical intermediate in Proteus mirabilis catalase by directed mutagenesis and consequences for nucleotide reactivity
Biochemistry (2001) 40(45) : 13734-43

Arlaud, G. J., Gaboriaud, C., Thielens, N. M., Rossi, V., Bersch, B., Hernandez, J. F. and Fontecilla Camps, J. C.
Structural biology of C1 : dissection of a complex molecular machinery.
Immunological Reviews (2001) 180 : 136-145

Buisson, M., Valette, E., Hernandez, J. F., Baudin, F., Ebel, C., Morand, P., Seigneurin, J. M., Arlaud, G. J. and Ruigrok, R. W.
Functional determinants of the Epstein-Barr virus protease.
Journal of Molecular Biology (2001) 311(1) : 217-28

Durmort C, Stehlin C, Schoehn G, Mitraki A, Drouet E, Cusack S and Burmeister WP
Structure of the fiber head of Ad3, a non-CAR-binding serotype of adenovirus
Virology (2001) 285(2) : 302-12

Franzetti, B., Schoehn, G., Ebel, C., Gagnon, J., Ruigrok, R. W. and Zaccai, G.
Characterization of a novel complex from halophilic archaebacteria, which displays chaperone-like activities in vitro.
Journal of Biological Chemistry (2001) 276(32) : 29906-14

Grizot S, Grandvaux N, Fieschi F, Faure J, Massenet C, Andrieu JP, Fuchs A, Vignais PV, Timmins PA, Dagher MC and Pebay Peyroula E
Small angle neutron scattering and gel filtration analyses of neutrophil NADPH oxidase cytosolic factors highlight the role of the C-terminal end of p47(phox) in the association with p40(phox)
Biochemistry (2001) 40(10) : 3127-3133

Heitz, A., Hernandez, J. F., Gagnon, J., Hong, T. T., Pham, T. T. C., Nguyen, T. M., Le Nguyen, D. and Chiche, L.
Solution structure of the squash trypsin inhibitor MCoTI-II. A new family for cyclic knottins.
Biochemistry (2001) 40(27) : 7973-7983

Kardos J, Gal P, Szilagyi L, Thielens NM, Szilagyi K, Lorincz Z, Kulcsar P, Graf L, Arlaud GJ and Zavodszky P
The role of the individual domains in the structure and function of the catalytic region of a modular serine protease, C1r
Journal of Immunology (2001) 167(9) : 5202-8

Lacroix, M., Ebel, C., Kardos, J., Dobo, J., Gal, P., Zavodszky, P., Arlaud, G. J. and Thielens, N. M.
Assembly and enzymatic properties of the catalytic domain of human complement protease C1r
Journal of Biological Chemistry (2001) 276(39) : 36233-40

Rossi, V., Cseh, S., Bally, I., Thielens, N. M., Jensenius, J. C. and Arlaud, G. J.
Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and-2.
Journal of Biological Chemistry (2001) 29 : 29

Tacnet-Delorme P, Chevallier S and Arlaud GJ
beta-Amyloid Fibrils Activate the C1 Complex of Complement Under Physiological Conditions : Evidence for a Binding Site for Abeta on the C1q Globular Regions
Journal of Immunology (2001) 167(11) : 6374-81

Tetaert D, Richet C, Gagnon J, Boersma A and Degand P
Studies of acceptor site specificities for three members of UDP- GalNAc:N-acetylgalactosaminyltransferases by using a synthetic peptide mimicking the tandem repeat of MUC5AC
Carbohydrate Research (2001) 333(2) : 165-71

Tetaert D, Ten Hagen KG, Richet C, Boersma A, Gagnon J and Degand P
Glycopeptide N-acetylgalactosaminyltransferase specificities for O- glycosylated sites on MUC5AC mucin motif peptides
Biochemical Journal (2001) 357(Pt 1) : 313-20

Thielens, N. M., Cseh, S., Thiel, S., Vorup-Jensen, T., Rossi, V., Jensenius, J. C. and Arlaud, G. J.
Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL.
Journal of Immunology (2001) 166(8) : 5068-77

Publications 2000

Bajtay, Z., Jozsi, M., Banki, Z., Thiel, S., Thielens, N. and Erdei, A.
Mannan-binding lectin and C1q bind to distinct structures and exert differential effects on macrophages.
European Journal of Immunology (2000) 30(6) : 1706-13

Hernandez, J. F., J. Gagnon, L. Chiche, T. M. Nguyen, J. P. Andrieu, A. Heitz, T. Trinh Hong, T. T. Pham and D. Le Nguyen
Squash trypsin inhibitors from Momordica cochinchinensis exhibit an atypical macrocyclic structure.
Biochemistry (2000) 39(19) : 5722-5730

Gaboriaud, C., Rossi, V., Bally, I., Arlaud, G. J. and Fontecilla-Camps, J. C.
Crystal structure of the catalytic domain of human complement c1s : a serine protease with a handle.
Embo Journal (2000) 19(8) : 1755-65

Luckey, M., J. Hernandez, G. Arlaud, V. T. Forsyth, R. W. Ruigrok and A. Mitraki
A peptide from the adenovirus fiber shaft forms amyloid-type fibrils
FEBS Letters (2000) 468(1) : 23-7

Morales, R., M. H. Charon, G. Hudry-Clergeon, Y. Petillot, S. Norager, M. Medina and M. Frey
Refined X-ray Structures of the Oxidized, at 1.3 A, and Reduced, at 1.17 A, [2Fe-2S] Ferredoxin from the Cyanobacterium Anabaena PCC7119 Show Redox-Linked Conformational Changes.
Biochemistry (2000) 39(9) : 2428

Zatylny, C., Gagnon, J., Boucaud-Camou, E. and Henry, J.
ILME : a waterborne pheromonal peptide released by the eggs of Sepia officinalis.
Biochemical & Biophysical Research Communications (2000) 275(1) : 217-22

Zatylny, C., Gagnon, J., Boucaud-Camou, E. and Henry, J.
The SepOvotropin : A new ovarian peptide regulating oocyte transport in sepia officinalis
Biochemistry & Biophysical Research Communications (2000) 276(3) : 1013-8