FDP Publications
Publications 2010
Blackledge M
Mapping the conformational mobility of multidomain proteins.
Biophysical Journal (2010) 98(10) : 2043-2044
Jensen MR, Salmon L, Nodet G and Blackledge M
Defining conformational ensembles of intrinsically disordered and partially folded proteins directly from chemical shifts.
Journal of the American Chemical Society (2010) 132(4) : 1270-1272
Lewandowski JR, Sein J, Blackledge M and Emsley L
Anisotropic collective motion contributes to nuclear spin relaxation in crystalline proteins.
Journal of the American Chemical Society (2010) 132(4) : 1246-1248
Lewandowski JR, Sein J, Sass HJ, Grzesiek S, Blackledge M and Emsley L
Measurement of site-specific (13)C spin-lattice relaxation in a crystalline protein.
Journal of the American Chemical Society (2010) 132(24) : 8252-8254
Markwick PR, Cervantes CF, Abel BL, Komives EA, Blackledge M and McCammon JA
Enhanced conformational space sampling improves the prediction of chemical shifts in proteins.
_ Journal of the American Chemical Society (2010) 132(4) : 1220-1221
Salmon L, Nodet G, Ozenne V, Yin G, Jensen MR, Zweckstetter M and Blackledge M
NMR characterization of long-range order in intrinsically disordered proteins.
Journal of the American Chemical Society (2010) 132(24) : 8407-8418
Vajpai N, Gentner M, Huang JR, Blackledge M and Grzesiek S
Side-chain chi(1) conformations in urea-denatured ubiquitin and protein G from (3)J coupling constants and residual dipolar couplings.
Journal of the American Chemical Society (2010) 132(9) : 3196-3203
Publications 2009
Bernadó P and Blackledge M
A self-consistent description of the conformational behavior of chemically denatured proteins from NMR and small angle scattering.
Biophysical Journal (2009) 97(10) : 2839-2845
Cho MK, Nodet G, Kim HY, Jensen MR, Bernado P, Fernandez CO, Becker S, Blackledge M and Zweckstetter M
Structural characterization of alpha-synuclein in an aggregation prone state.
Protein Science (2009) 18(9) : 1840-1846
Estrada J, Bernado P, Blackledge M and Sancho J
ProtSA : a web application for calculating sequence specific protein solvent accessibilities in the unfolded ensemble.
BMC Bioinformatics (2009) 10 : 104
Fischer D, Mukrasch MD, Biernat J, Bibow S, Blackledge M, Griesinger C, Mandelkow E and Zweckstetter M
Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules.
Biochemistry (2009) 48(42) : 10047-10055
Gabel F, Jensen MR, Zaccai G and Blackledge M
Quantitative modelfree analysis of urea binding to unfolded ubiquitin using a combination of small angle X-ray and neutron scattering.
Journal of the American Chemical Society (2009) 131(25) : 8769-8771
Lewandowski JR, Sein J, Blackledge M and Emsley L
Anisotropic Collective Motion Contributes to Nuclear Spin Relaxation in Crystalline Proteins.
Journal of the American Chemical Society (2009) 132(4) : 1246-1248
Markwick PR, Bouvignies G, Salmon L, McCammon JA, Nilges M and Blackledge M
Toward a unified representation of protein structural dynamics in solution.
Journal of the American Chemical Society (2009) 131(46) : 16968-16975
Markwick PR, Showalter SA, Bouvignies G, Bruschweiler R and Blackledge M
Structural dynamics of protein backbone phi angles : extended molecular dynamics simulations versus experimental (3) J scalar couplings.
Journal of Biomolecular NMR (2009) 45(1-2) : 17-21
Nodet G, Salmon L, Ozenne V, Meier S, Jensen MR and Blackledge M
Quantitative description of backbone conformational sampling of unfolded proteins at amino acid resolution from NMR residual dipolar couplings.
Journal of the American Chemical Society (2009) 131(49) : 17908-17918
Ortega-Roldan JL, Jensen MR, Brutscher B, Azuaga AI, Blackledge M and van Nuland NA
Accurate characterization of weak macromolecular interactions by titration of NMR residual dipolar couplings : application to the CD2AP SH3-C:ubiquitin complex.
Nucleic Acids Research (2009) 37(9) : e70
Ringkjøbing-Jensen M, Markwick PRL, Meier S, Griesinger C, Zweckstetter M, Grzesiek S, Bernadó P and Blackledge M
Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings.
Structure (2009) 17(9) : 1169-1185
Salmon L, Bouvignies G, Markwick P, Lakomek N, Showalter S, Li DW, Walter K, Griesinger C, Bruschweiler R and Blackledge M
Protein conformational flexibility from structure-free analysis of NMR dipolar couplings : quantitative and absolute determination of backbone motion in ubiquitin.
Angewandte Chemie International Edition England (2009) 48(23) : 4154-4157
Publications 2008
Bouvignies G, Markwick PR and Blackledge M
Characterization of protein dynamics from residual dipolar couplings using the three dimensional Gaussian axial fluctuation model. restaurants.
Proteins (2008) 71(1) : 353-363
Hus JC, Salmon L, Bouvignies G, Lotze J, Blackledge M and Bruschweiler R
16-fold degeneracy of peptide plane orientations from residual dipolar couplings : Analytical treatment and implications for protein structure determination.
Journal of the American Chemical Society (2008) 130(47) : 15927-15937
Jensen MR and Blackledge M
On the origin of NMR dipolar waves in transient helical elements of partially folded proteins.
Journal of the American Chemical Society (2008) 130(34) : 11266-11267
Jensen MR, Houben K, Lescop E, Blanchard L, Ruigrok RW and Blackledge M
Quantitative conformational analysis of partially folded proteins from residual dipolar couplings : application to the molecular recognition element of Sendai virus nucleoprotein.
Journal of the American Chemical Society (2008) 130(25) : 8055-8061
Meier S, Blackledge M and Grzesiek S
Conformational distributions of unfolded polypeptides from novel NMR techniques.
Journal of Chemical Physics (2008) 128(5) : 052204
Mylonas E, Hascher A, Bernado P, Blackledge M, Mandelkow E and Svergun DI
Domain conformation of tau protein studied by solution small-angle X-ray scattering.
Biochemistry (2008) 47(39) : 10345-10353
Ribeiro EA, Favier A, Gerard FCA, Leyrat C, Brutscher B, Blondel D, Ruigrok RW, Blackledge M and Jamin M
Solution structure of the C-terminal nucleoprotein-RNA binding domain of the vesicular stomatitis virus phosphoprotein.
Journal of Molecular Biology (2008) 382(2) : 525-538
Wells M, Tidow H, Rutherford TJ, Markwick P, Jensen MR, Mylonas E, Svergun DI, Blackledge M and Fersht AR
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.
Proceedings of the National Academy of Sciences U S A (2008) 105(15) : 5762-5767
Publications 2007
Bernado P, Mylonas E, Petoukhov MV, Blackledge M and Svergun DI
Structural characterization of flexible proteins using small-angle X-ray scattering.
Journal of the American Chemical Society (2007) 129(17) : 5656-5664
Boudet J, Duval V, Van Melckebeke H, Blackledge M, Amoroso A, Joris B and Simorre JP
Conformational and thermodynamic changes of the repressor/DNA operator complex upon monomerization shed new light on regulation mechanisms of bacterial resistance against beta-lactam antibiotics.
Nucleic Acids Research (2007) 35(13) : 4384-4395
Bouvignies G, Markwick PR and Blackledge M
Simultaneous definition of high resolution protein structure and backbone conformational dynamics using NMR residual dipolar couplings.
Chemphyschem (2007) 8(13) : 1901-1909
Cho MK, Kim HY, Bernado P, Fernandez CO, Blackledge M and Zweckstetter M
Amino acid bulkiness defines the local conformations and dynamics of natively unfolded alpha-synuclein and tau.
Journal of the American Chemical Society (2007) 129(11) : 3032-3033
Giraud N, Blackledge M, Bockmann A and Emsley L
The influence of nitrogen-15 proton-driven spin diffusion on the measurement of nitrogen-15 longitudinal relaxation times.
Journal of Magnetic Resonance (2007) 184(1) : 51-61
Houben K, Blanchard L, Blackledge M and Marion D
Intrinsic dynamics of the partly unstructured PX domain from the Sendai virus RNA polymerase co-factor P.
Biophysical Journal (2007) 93(8) : 2830-2844
Markwick PR, Bouvignies G and Blackledge M
Exploring multiple timescale motions in protein GB3 using accelerated molecular dynamics and NMR spectroscopy.
Journal of the American Chemical Society (2007) 129(15) : 4724-4730
Meier S, Grzesiek S and Blackledge M
Mapping the conformational landscape of urea-denatured ubiquitin using residual dipolar couplings.
Journal of the American Chemical Society (2007) 129(31) : 9799-9807
Meier S, Strohmeier M, Blackledge M and Grzesiek S
Direct observation of dipolar couplings and hydrogen bonds across a beta-hairpin in 8 M urea.
Journal of the American Chemical Society (2007) 129(4) : 754-755
Mukrasch MD, Markwick P, Biernat J, Bergen M, Bernado P, Griesinger C, Mandelkow E, Zweckstetter M and Blackledge M
Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation.
Journal of the American Chemical Society (2007) 129(16) : 5235-5243
Sein J, Giraud N, Blackledge M and Emsley L
The role of (15)N CSA and CSA/dipole cross-correlation in (15)N relaxation in solid proteins.
Journal of Magnetic Resonance (2007) 168(1) : 26-33
Publications 2006
Bernado P, Blackledge M and Sancho J
Sequence-specific solvent accessibilities of protein residues in unfolded protein ensembles.
Biophysical Journal (2006) 91(12) : 4536-4543
Bouvignies G, Markwick P, Bruschweiler R and Blackledge M
Simultaneous determination of protein backbone structure and dynamics from residual dipolar couplings.
Journal of the American Chemical Society (2006) 128(47) : 15100-15101
Bouvignies G, Meier S, Grzesiek S and Blackledge M
Ultrahigh-resolution backbone structure of perdeuterated protein GB1 using residual dipolar couplings from two alignment media.
Angewandte Chemie International Edition (2006) 45(48) : 8166-8169
Dames SA, Aregger R, Vajpai N, Bernado P, Blackledge M and Grzesiek S
Residual dipolar couplings in short peptides reveal systematic conformational preferences of individual amino acids.
Journal of the American Chemical Society (2006) 128(41) : 13508-13514
Giraud N, Sein J, Pintacuda G, Bockmann A, Lesage A, Blackledge M and Emsley L
Observation of heteronuclear overhauser effects confirms the N-15-H-1 dipolar relaxation mechanism in a crystalline protein.
Journal of the American Chemical Society (2006) 128(38) : 12398-12399
Reinscheid UM, Farjon J, Radzom M, Haberz P, Zeeck A, Blackledge M and Griesinger C
Effect of the solvent on the conformation of a depsipeptide : NMR-derived solution structure of hormaomycin in DMSO from residual dipolar couplings in a novel DMSO-compatible alignment medium.
Chembiochem (2006) 7(2) : 287-296
Skora L, Cho MK, Kim HY, Fernandez C, Blackledge M and Zweckstetter M
Charge-induced molecular alignment of intrinsically disordered proteins.
Angewandte Chemie International Edition (2006) 45 : 7012-7015
Publications 2005
Bernado P, Bertoncini CW, Griesinger C, Zweckstetter M and Blackledge M
Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings.
Journal of the American Chemical Society (2005) 127(51) : 17968-17969
Bernado P, Blanchard L, Timmins P, Marion D, Ruigrok RW and Blackledge M
A structural model for unfolded proteins from residual dipolar couplings and small-angle x-ray scattering.
Proceedings of the National Academy of Sciences U S A (2005) 102(47) : 17002-17007
Blackledge M
Recent progress in the study of biomolecular structure and dynamics in solution from residual dipolar couplings.
Progress in Nuclear Magnetic Resonance Spectroscopy (2005) 46(1) : 23-61
Bouvignies G, Bernado P and Blackledge M
Protein backbone dynamics from N-HN dipolar couplings in partially aligned systems : a comparison of motional models in the presence of structural noise.
Journal of Magnetic Resonance (2005) 173(2) : 328-338
Bouvignies G, Bernado P, Meier S, Cho K, Grzesiek S, Bruschweiler R and Blackledge M
Identification of slow correlated motions in proteins using residual dipolar and hydrogen-bond scalar couplings.
Proceedings of the National Academy of Sciences U S A (2005) 102(39) : 13885-13890
Giraud N, Blackledge M, Goldman M, Bockmann A, Lesage A, Penin F and Emsley L
Quantitative analysis of backbone dynamics in a crystalline protein from nitrogen-15 spin-lattice relaxation.
Journal of the American Chemical Society (2005) 127(51) : 18190-18201
Sibille N, Blackledge M, Brutscher B, Coves J and Bersch B
Solution structure of the sulfite reductase flavodoxin-like domain from Escherichia coli.
Biochemistry (2005) 44(25) : 9086-9095.
Publications 2004
Bernado P and Blackledge M
Anisotropic small amplitude peptide plane dynamics in proteins from residual dipolar couplings.
Journal of the American Chemical Society (2004) 126(15) : 4907-4920
Bernadó P and Blackledge M
Local dynamic amplitudes on the protein backbone from dipolar couplings : toward the elucidation of slower motions in biomolecules.
Journal of the American Chemical Society (2004) 126(25) : 7760 - 1761
Blanchard L, Tarbouriech N, Blackledge M, Timmins P, Burmeister WP, Ruigrok RWH and Marion D
Structure and dynamics of the nucleocapsid-binding domain of the Sendai virus phosphoprotein in solution.
Virology (2004) 319(2) : 201-211
Bouvignies G, Bernado P and Blackledge M
Modélisation de la dynamique de la chaîne peptidique des protéines en solution par RMN à travers les couplages dipolaires residuels.
Journal de Physique IV (2005) 130 : 229-244
Giraud N, Böckmann A, Lesage A, Penin F, Blackledge M and Emsley L
Site-specific backbone dynamics from a crystalline protein by solid-state NMR spectroscopy.
Journal of the American Chemical Society (2004) 126(37) : 11422 - 11423
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