X-ray diffraction

Presentation

Two independent laboratory X-ray sources with high performance optics (Osmic & Xenocs muti-layer mirrors) and image-plate detector systems, available for routine data collection and screening of macromolecular and small molecule crystals.

The in-house X-ray platform is typically used for sample screening and optimisation (cryo-cooling or derivatization parameters) prior to data collection on a synchrotron source, however, for well-diffracting samples, data of sufficient quality to phase de novo structures by classical approaches (MIR, sulphur SAD or MR) can be obtained.

Key words

protein crystallography, sample screening, structure determination.

Contact

• Platform responsible: Gavin FOX
• Co-responsible: Richard KAHN

Dedicated staff

Gavin FOX

Specific equipment

NONIUS Fr591 (Cu source), Osmic mirrors in KB geometry, MAR diffractometer with MAR345 image plate detector, Oxford 600 cryo-system. RIGAKU Rn-200Beh (Cu source), XENOCS toroidal multilayer mirror, MAR diffractometer with MAR300 image plate detector, Oxford 600 cryo-system.

Access mode

Open access to internal and external users.

Cost

Free to academic users.

Location

Institut de Biologie Structurale - LPM

How to make a request ?

Contact: Gavin FOX or Richard KAHN to make a reservation.

Additional information

This platform is undergoing a major upgrade with the new platform scheduled to become operational in 2010-11.