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Institut de Biologie StructuraleGrenoble / France

Contacts relatifs à cet article / WEISSENHORN Winfried

Thèses

03/2011 - 04/2015 Nick Aschman University Grenoble Alpes

Financement : Fond National de la Recherche Luxembourg

Publications :
M.G. Bego, É. A. Côt, N. Aschman, J. Mercier, W. Weissenhorn and E. A. Cohen (2015) Human Immunodeficiency Virus Accessory Protein Vpu Inhibits the Antiviral Response of Plasmacytoid Dendritic Cells for Innate Immune Evasion. PLoS Pathogen, 11(7):e1005024.
W. Weissenhorn, N. Miguet, N. Aschman, P. Renesto, Y. Usami, and H.G. Göttlinger (2012) Structural basis for tetherin function. Curr HIV Res. 10(4), 298-306.
N. Aschman, W. Weissenhorn and P. Renesto (2012) La tétherine, dernière amarre du VIH/ Tetherin, last link to HIV. Virologie, 16, 32-42.

10/2010 -09/2013 : Emilie Poudevigne, University Joseph Fourier

Financement : Bourse de l’Université de Grenoble

Publications :
J. Solomons, C. Sabin, Y. Usami, E. Poudevigne, D. Lutje-Hulsik, P. Macheboeuf, H.
Gottlinger and W. Weissenhorn (2010) Structural basis of ESCRT-III CHMP3 recruitment
of AMSH. Structure, 19(8), 1149-59.
W. Weissenhorn, E. Poudevigne, G. Effantin and P. Bassereau (2013) How to get out : ssRNA enveloped viruses and membrane fission. Current Opin Virol. 3, 159-167.

8/2009 a 10/2012 : Aurelien Dordor
Financement : DFG

Publications :
G. Effantin*, A. Dordor*, V. Sandrin, N. Martinelli, W.I. Sundquist, G. Schoehn and W. Weissenhorn (2013) ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding. Cell Microbiol., 15(2), 213-26.
* contributed equally)
N. Martinelli,, B. Hartlieb, C. Sabin, A. Dordor, Y. Usami, H. Göttlinger and W. Weissenhorn (2012) CC2D1A is a regulator of ESCRT-III CHMP4B. J. Mol. Biol., 419(1-2), 75-88.
A. Dordor, E. Poudevigne, H. Göttlinger and W. Weissenhorn (2011) Essential and supporting host cell factors for HIV-1 budding. Future Microbiol. 6 (10), 1159-1170

10/2008 à 12/2011 : Nicolas Martinelli
Financement : Région-Rhône-Alpes Cluster 10

Publications :
N. Martinelli,, B. Hartlieb, C. Sabin, A. Dordor, Y. Usami, H. Göttlinger and W. Weissenhorn (2012) CC2D1A is a regulator of ESCRT-III CHMP4B. J. Mol. Biol., 419(1-2), 75-88.
G. Bodon, R. Chassefeyre, K. Pernet-Gallay, N. Martinelli, G. Effantin, D. Lutje Hulsik, A. Belly, Y. Goldberg, C. Chatellard-Causse, B. Blot, G. Schoehn, W. Weissenhorn and R. Sadoul (2011) ESCRT-III CHMP2B polymerizes into helical structures deforming the plasma membrane. J. Boil. Chem. 286(46), 40276-86.
S. Peel, P. Macheboeuf, N. Martinelli and W. Weissenhorn (2011) Divergent pathways lead to ESCRT-III catalyzed membrane fission. Trends in Biochemical Sciences, 36(4), 199-210.
G. Effantin, A. Dordor, V. Sandrin, N. Martinelli, W.I. Sundquist, G. Schoehn and W. Weissenhorn (2013) ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding. Cell Microbiol., 15(2), 213-26.
* contributed equally)

10/2005 à 12/2009 : Miriam Hock Université Philipps de Marburg, Allemagne
Financement : SFB Marburg, DFG
Taux de co-encadrement ( 40 %)
Publications :
M. Hock, I. Kraus, G. Schoehn, M. Jamin, C. Andrei-Selmer, W. Garten and W. Weissenhorn (2010) RNA induced polymerization of the Borna disease virus nucleoprotein. Virology, 397, 64-72.

10/2005 à 09/2011 :Julianna Solomons, Université Joseph Fourier
Financement : EMBL et DFG
Publications :
J. Solomons, et al. W. Weissenhorn (2010) Structural basis of ESCRT-III CHMP3 recruitment of AMSH. Structure, 19(8), 1149-59.
Lata S, Schoehn G, Solomons J, Pires R, Göttlinger HG, Weissenhorn W. (2009) Structure and function of ESCRT-III. Biochem Soc Trans. 37, 156-160.
Lata S, Roessle M, Solomons J, Jamin M, Gottlinger HG, Svergun DI, Weissenhorn W. (2008) Structural basis for autoinhibition of ESCRT-III CHMP3. J Mol Biol. 378, 818-827.

10/2004 à 09/2008 : Ricardo Pires ; EMBL et Université Joseph Fourier
Financement : EMBL et DFG
Publications :
R. Pires, B. Hartlieb, L. Signor, G. Schoehn, S. Lata, M. Roessle, C. Moriscot, S. Popov, A. Hinz, M. Jamin, V. Boyer, R. Sadoul, E. Forest, D. I. Svergun, H. G. Göttlinger and W. Weissenhorn (2009) A crescent shaped ALIX dimer targets ESCRT-III CHMP4 filaments. Structure 17, 843-856.
Lata S, Schoehn G, Solomons J, Pires R, Göttlinger HG, Weissenhorn W. (2009) Structure and function of ESCRT-III. Biochem Soc Trans. 37, 156-160.
Lata S, Schoehn G, Jain A, Pires R, Piehler J, Gottlinger HG, Weissenhorn W. (2008) Helical structures of ESCRT-III are disassembled by VPS4. Science 321, 1354-1357.

11/2002 à 12/2006 : Bettina Hartlieb, Université Philipps de Marburg, Allemagne
Financement : SFB Marburg, German Research Council (DFG)
Taux de co-encadrement ( 20 %)
Publications :
B. Hartlieb, T. Muziol, W. Weissenhorn* and S. Becker* (2007) Crystal structure of the C-terminal domain of Ebola virus VP30 reveals a role in transcription and nucleocapsid assembly. Proc. Natl. Acad. Sci. USA, 104(2), 624-9 (*corresponding authors).
B. Hartlieb and W. Weissenhorn (2006) Filovirus assembly and budding. Virology, 344(1):64-70

10/1999 à 9/2003 : Vassiliy Bavro, Université Joseph Fourier et EMBL
Financement : Bourse Louis-Jeantet Fondation de Médicine ; Genève
Publications :
M. Sola*, V.N. Bavro*, M. Sola, V.N. Bavro, J. Timmins, S. T. Franz, Ricard-Blum, G. Schoehn, R. H.W. Ruigrok, G. A. O’Sullivan, T. Saiyed, B. Schmitt, H. Betz, and W. Weissenhorn (2004) Structural basis of dynamic glycine receptor clustering by gephyrin. EMBO J, 23(13):2510-9 (*equal contribution).
V.N. Bavro, M. Sola, A. Bracher, M. Kneussel, H. Betz, and W. Weissenhorn (2002) Crystal structure of the GABAA receptor associated protein, GABARAP. EMBO Rep. 3, 183-189.

10/1998 à 9/2002 : Joanna Timmins, EMBL et Open University London ;
Financement : EMBL
Publications :
T. Hoenen, V. Volchkov, L. Kolesnikova, E. Mittler, J. Timmins, M. Ottmann, O. Reynard, S. Becker and W. Weissenhorn (2005) VP40 octamers are essential for Ebola virus replication. J. Virol. 79(3), 1898-905.
M. Sola, V.N. Bavro, J. Timmins, et al. W. Weissenhorn (2004) Structural basis of dynamic glycine receptor clustering by gephyrin EMBO J, 23(13):2510-9..
J. Timmins, R.H.W. Ruigrok, and W. Weissenhorn (2004) Structural studies on the Ebola virus matrix protein VP40 indicate that matrix proteins of enveloped RNA viruses are analogues but not homologues. FEMS Microbiol.Lett.15 ; 233(2), 179-86.
J. Timmins, G., Schoehn, C. Kohlhaas, H.-D. Klenk, R.W.H., Ruigrok and W. Weissenhorn (2003) Oligomerization and polymerization of the filovirus matrix protein VP40. Virology, 312, 359-368.
F. X. Gomis-Rüth, A. Dessen, J. Timmins, et al. W. Weissenhorn (2003) The matrix protein VP40 from Ebola virus octamerizes into pore-like structures with specific RNA binding properties. Structure (Cambridge), 11, 423-433.
J. Timmins, et al. W. Weissenhorn (2003) Ebola virus matrix protein VP40 interaction with human cellular factors Tsg101 and Nedd4. J. Mol. Biol. 326, 493-502.
J. Timmins, S. Scianimanico, G. Schoehn, and W. Weissenhorn (2001) Vesicular release of Ebola virus matrix protein VP40. Virology, 283, 1-6.
S. Scianimanico, G. Schoehn, J. Timmins, R. H. W. Ruigrok, H.-D. Klenk, and W. Weissenhorn (2000) Membrane association induces a conformational change in the Ebola virus matrix protein. EMBO J., 19, 6732-6741.