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Institut de Biologie StructuraleGrenoble / France

Publications depuis 2015

La liste des publications du groupe parues dans des revues à comité de lecture depuis 2015, ainsi que les ouvrages et chapitres d’ouvrage, est consultable ici (données issues de HAL-IBS).

Publications jusqu’à 2014

Publications 2014

Barbet-Massin E, Schneider R, Felletti M, Jehle S, Communie G, Martinez N, Jensen MR, Ruigrok RWH, Emsley L, Lesage A, Blackledge M, Pintacuda P
Insights into the structure and dynamics of measles virus nucleocapsids by 1H-detected solid-state
NMR Biophys. J (In Press)

Blanc M, Coetzer TL, Blackledge M, Haertlein M, Mitchell EP, Forsyth VT, Jensen MR.
Intrinsic disorder within the erythrocyte binding-like proteins from Plasmodium falciparum.
Biochim Biophys Acta ;1844(12):2306-2314

Communie G, Ruigrok RWH, Jensen MR and Blackledge M
Intrinsically disordered proteins implicated in paramyxoviral replication machinery. Curr. Opin. Virol. 5, 72–81.

Huang J-R, Warner LR, Sanchez C, Gabel F, Madl T, Mackereth CD, Sattler M and Blackledge M
Transient Electrostatic Interactions Dominate the Conformational Equilibrium Sampled by Multidomain Splicing Factor U2AF65 : A Combined NMR and SAXS Study.
J. Am. Chem. Soc. 136, 7068–7076

Jensen MR and Blackledge M
Testing the validity of ensemble descriptions of intrinsically disordered proteins.
Proc. Natl. Acad. Sci. U. S. A. 111, E1557–1558.

Jensen MR, Zweckstetter M, Huang J-R and Blackledge M
Exploring Free-Energy Landscapes of Intrinsically Disordered Proteins at Atomic Resolution Using NMR Spectroscopy.
Chemical Reviews. (In Press)

Krishnan N, Koveal D, Miller D H, Xue B, Akshinthala SD, Kragelj J, Jensen MR, Gauss C-M, Page R, Blackledge M, Muthuswamy SK, Peti W and Tonks NK
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.
Nat. Chem. Biol. (In Press)

Long D, Bouvignies G and Kay LE.
Measuring Hydrogen Exchange Rates in Invisible Protein Excited States.
Proceedings of the National Academy of Sciences of the USA in press

Morin S, Linnet TE, Lescanne M, Schanda P, Thompson GS, Tollinger M, Teilum K, Gagné S, Marion D, Griesinger C, Blackledge M and d’ Auvergne, E J
relax : the analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data.
Bioinformatics. (In Press)

Ozenne V, Noel JK, Heidarsson PO, Brander S, Poulsen FM, Jensen MR, Kragelund BB, Blackledge M and Danielsson, J.
Exploring the minimally frustrated energy landscape of unfolded ACBP.
J. Mol. Biol. 426, 722–734.

Parigi G, Rezaei-Ghaleh N, Giachetti A, Becker S, Fernandez C, Blackledge M, Griesinger C, Zweckstetter M, Luchinat C.
Long-range correlated dynamics in intrinsically disordered proteins.
J Am Chem Soc. ;136(46):16201-9.

Rasheed M, Richter C, Chisty LT, Kirkpatrick J, Blackledge M, Webb MR and Driscoll PC.
Ligand-dependent dynamics of the active-site lid in bacterial dimethylarginine dimethylaminohydrolase.
Biochemistry 53, 1092–1104.

Schwalbe M, Ozenne V, Bibow S, Jaremko M, Jaremko L, Gajda M, Jensen MR, Biernat J, Becker S, Mandelkow E, Zweckstetter M and Blackledge M. 
Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering.
Structure 22, 238–249.

Sterckx YGJ, Volkov AN, Vranken WF, Kragelj J, Jensen MR, Buts L, Garcia-Pino A, Jové T, Van Melderen L, Blackledge M, van Nuland NAJ and Loris R
Small-Angle X-Ray Scattering- and Nuclear Magnetic Resonance-Derived Conformational Ensemble of the Highly Flexible Antitoxin PaaA2.
Structure (In Press)

Sukackaite R, Jensen MR, Mas PJ, Blackledge M, Buonomo SB and Hart DJ.
Structural and Biophysical Characterization of Murine Rif1 C Terminus Reveals High Specificity for DNA Cruciform Structures.
J. Biol. Chem. (In Press)

Varadi M, Kosol S, Lebrun P, Valentini E, Blackledge M, Dunker AK, Felli IC, Forman-Kay JD, Kriwacki RW, Pierattelli R, Sussman J, Svergun DI, Uversky VN, Vendruscolo M, Wishart D, Wright PE and Tompa P
pE-DB : a database of structural ensembles of intrinsically disordered and of unfolded proteins.
Nucleic Acids Res. 42, D326–335.

Publications 2013

Communie G, Crepin T, Maurin D, Jensen MR, Blackledge M and Ruigrok RWH
Structure of the tetramerization domain of measles virus phosphoprotein.
Journal of Virology (2013) 87(12) : 7166-7169

Communie G, Habchi J, Yabukarski F, Blocquel D, Schneider R, Tarbouriech N, Papageorgiou N, Ruigrok RW, Jamin M, Ringkjobing Jensen M, Longhi S and Blackledge M
Atomic resolution description of the interaction between the nucleoprotein and phosphoprotein of Hendra virus.
PLoS Pathogens (2013) 9(9) : e1003631

Guerry P, Mollica L and Blackledge M
Mapping protein conformational energy landscapes using NMR and molecular simulation.
Chemphyschem (2013) 14(13) : 3046-3058

Guerry P, Salmon L, Mollica L, Ortega Roldan JL, Markwick P, van Nuland NA, McCammon JA and Blackledge M
Mapping the population of protein conformational energy sub-States from NMR dipolar couplings.
Angewandte Chemie International Edition (2013) 52(11) : 3181-3185

Huang JR, Ozenne V, Jensen MR and Blackledge M
Direct prediction of NMR residual dipolar couplings from the primary sequence of unfolded proteins.
Angewandte Chemie International Edition (2013) 52(2) : 687-690

Jensen MR, Ruigrok RW and Blackledge M
Describing intrinsically disordered proteins at atomic resolution by NMR.
Current Opinion in Structural Biology (2013) 23(3) : 426-435

Iesmantavicius V, Jensen MR, Ozenne V, Blackledge M, Poulsen FM and Kjaergaard M
Modulation of the intrinsic helix propensity of an intrinsically disordered protein reveals long-range helix-helix interactions.
Journal of the American Chemical Society (2013) 135(27) : 10155-10163

Kragelj J, Ozenne V, Blackledge M and Ringkjobing Jensen M
Conformational propensities of intrinsically disordered proteins from NMR chemical shifts.
Chemphyschem (2013) 14(13) : 3034-3045

Mollica L, Baias M, Lewandowski JR, Wylie BJ, Sperling LJ, Rienstra CM, Emsley L and Blackledge M
Atomic-resolution structural dynamics in crystalline proteins from NMR and molecular simulation.
Journal of Physical Chemistry Letters (2013) 3(23) : 3657-3662

Ortega Roldan JL, Casares S, Ringkjobing Jensen M, Cardenes N, Bravo J, Blackledge M, Azuaga AI and van Nuland NA
Distinct ubiquitin binding modes exhibited by SH3 domains : Molecular determinants and functional implications.
PLoS One (2013) 8(9) : e73018

Pietrucci F, Mollica L and Blackledge M
Mapping the native conformational ensemble of proteins from a combination of simulations and experiments : New insight into the src-SH3 domain.
_ Journal of Physical Chemistry Letters (2013) 4(11) : 1943-1948

Schneider R, Odronitz F, Hammesfahr B, Hellkamp M and Kollmar M
Peakr : simulating solid-state NMR spectra of proteins.
Bioinformatics (2013) 29(9) : 1134-1140

Schwalbe M, Biernat J, Bibow S, Ozenne V, Jensen MR, Kadavath H, Blackledge M, Mandelkow E and Zweckstetter M
Phosphorylation of human tau protein by microtubule affinity-regulating kinase 2.
_ Biochemistry (2013) 52(50) : 9068-9079

Publications 2012

Huang JR, Gabel F, Jensen MR, Grzesiek S and Blackledge M
Sequence-specific mapping of the interaction between urea and unfolded ubiquitin from ensemble analysis of NMR and small angle scattering data.
Journal of the American Chemical Society (2012) 134(9) : 4429-4436

Huang JR, Gentner M, Vajpai N, Grzesiek S and Blackledge M
Residual dipolar couplings measured in unfolded proteins are sensitive to amino-acid specific geometries as well as local conformational sampling.
Biochemical Society Transactions (2012) 40(5) : 989-994

Leyrat C, Schneider R, Ribeiro JEA, Yabukarski F, Yao M, Gerard FC, Jensen MR, Ruigrok RW, Blackledge M and Jamin M
Ensemble structure of the modular and flexible full-length vesicular stomatitis virus phosphoprotein.
Journal of Molecular Biology (2012) 423(2) : 182-197

Mollica L, Baias M, Lewandowski JR, Wylie BJ, Sperling LJ, Rienstra CM, Emsley L and Blackledge M
Atomic-resolution structural dynamics in crystalline proteins from NMR and molecular simulation.
Journal of Physical Chemistry Letters (2012) 3(23) : 3657-3662

Ozenne V, Bauer F, Salmon L, Huang JR, Jensen MR, Segard S, Bernado P, Charavay C and Blackledge M
Flexible-meccano : a tool for the generation of explicit ensemble descriptions of intrinsically disordered proteins and their associated experimental observables.
Bioinformatics (2012) 28(11) : 1463-1470

Ozenne V, Schneider R, Yao M, Huang JR, Salmon L, Zweckstetter M, Jensen MR and Blackledge M
Mapping the potential energy landscape of intrinsically disordered proteins at amino acid resolution.
Journal of the American Chemical Society (2012) 134(36) : 15138-15148

Rezaei-Ghaleh N, Blackledge M and Zweckstetter M
Intrinsically disordered proteins : From sequence and conformational properties toward drug discovery.
Chembiochem (2012) 13(7) : 930-950

Salmon L, Jensen MR, Bernado P and Blackledge M
Measurement and analysis of NMR residual dipolar couplings for the study of intrinsically disordered proteins.
Methods in Molecular Biology (2012) 895 : 115-125

Salmon L, Pierce L, Grimm A, Ortega Roldan JL, Mollica L, Jensen MR, van Nuland N, Markwick PR, McCammon JA and Blackledge M
Multi-timescale conformational dynamics of the SH3 domain of CD2-associated protein using NMR spectroscopy and accelerated molecular dynamics.
Angewandte Chemie International Edition (2012) 51(25) : 6103-6106

Schneider R, Huang JR, Yao M, Communie G, Ozenne V, Mollica L, Salmon L, Ringkjobing Jensen M and Blackledge M
Towards a robust description of intrinsic protein disorder using nuclear magnetic resonance spectroscopy.
Molecular Biosystems (2012) 8 (1) : 58-68

Silvers R, Sziegat F, Tachibana H, Segawa S, Whittaker S, Gunther UL, Gabel F, Huang JR, Blackledge M, Wirmer-Bartoschek J and Schwalbe H
Modulation of structure and dynamics by disulfide bond formation in unfolded states.
Journal of the American Chemical Society (2012) 134(15) : 6846-6854

Sziegat F, Silvers R, Hahnke M, Jensen MR, Blackledge M, Wirmer-Bartoschek J and Schwalbe H
Disentangling the coil : Modulation of conformational and dynamic properties by site-directed mutation in the non-native state of hen egg white lysozyme.
Biochemistry (2012) 51(16) : 3361-3372

Zachariae U, Schneider R, Briones R, Gattin Z, Demers JP, Giller K, Maier E, Zweckstetter M, Griesinger C, Becker S, Benz R, de Groot BL and Lange A
beta-barrel mobility underlies closure of the voltage-dependent anion channel.
Structure (2012) 20(9) : 1540-1549

Publications 2011

Bibow S, Ozenne V, Biernat J, Blackledge M, Mandelkow E and Zweckstetter M
Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau.
Journal of the American Chemical Society (2011) 133 (40) : 15842-15845

Dupeux F, Santiago J, Betz K, Twycross J, Park SY, Rodriguez L, Gonzalez-Guzman M, Jensen MR, Krasnogor N, Blackledge M, Holdsworth M, Cutler SR, Rodriguez PL and Márquez JA
A thermodynamic switch modulates abscisic acid receptor sensitivity.
EMBO Journal (2011) 30 (20) : 4174-4184

Habchi J, Blangy S, Mamelli L, Ringkjobing Jensen M, Blackledge M, Darbon H, Oglesbee M, Shu Y and Longhi S
Characterization of the interactions between the nucleoprotein and the phosphoprotein of henipaviruses.
Journal of Biological Chemistry (2011) 286 (15) : 13583-13602

Jensen MR, Communie G, Ribeiro EA, Jr., Martinez N, Desfosses A, Salmon L, Mollica L, Gabel F, Jamin M, Longhi S, Ruigrok RW and Blackledge M
Intrinsic disorder in measles virus nucleocapsids.
Proceedings of the National Academy of Sciences (2011) 108 (24) : 9839-9844

Jensen MR, Ortega-Roldan JL, Salmon L, van Nuland N and Blackledge M
Characterizing weak protein-protein complexes by NMR residual dipolar couplings.
European Biophysics Journal (2011) 40 (12) : 1371-1381

Lewandowski JR, Sass HJ, Grzesiek S, Blackledge M and Emsley L
Site-specific measurement of slow motions in proteins.
Journal of the American Chemical Society (2011) 133 (42) : 16762-16765

Leyrat C, Ringkjobing Jensen M, Ribeiro Jr. EA, Gerard F, Ruigrok RW, Blackledge M and Jamin M
The N(0)-binding region of the vesicular stomatitis virus phosphoprotein is globally disordered but contains transient alpha-helices.
Protein Science (2011) 20 (3) : 542-556

Leyrat C, Yabukarski F, Tarbouriech N, Ribeiro Jr EA, Jensen MR, Blackledge M, Ruigrok RWH and Jamin M
Structure of the vesicular stomatitis virus n0-p complex.
PLoS Pathogens (2011) 7 (9) : e1002248

Roldan JL, Blackledge M, van Nuland NA and Azuaga AI
Solution structure, dynamics and thermodynamics of the three SH3 domains of CD2AP.
Journal of Biomolecular NMR (2011) 50 (2) : 103-117

Salmon L, Bouvignies G, Markwick P and Blackledge M
Nuclear magnetic resonance provides a quantitative description of protein conformational flexibility on physiologically important time scales.
Biochemistry (2011) 50 (14) : 2735-2747

Salmon L, Ortega Roldan JL, Lescop E, Licinio A, van Nuland N, Jensen MR and Blackledge M
Structure, dynamics, and kinetics of weak protein-protein complexes from NMR spin relaxation measurements of titrated solutions.
Angewandte Chemie International Edition (2011) 50 (16) : 3755-3759

Tosi T, Nickerson NN, Mollica L, Jensen MR, Blackledge M, Baron B, England P, Pugsley AP and Dessen A
Pilotin-secretin recognition in the type II secretion system of Klebsiella oxytoca.
Molecular Microbiology (2011) 82 (6) : 1422-1432

Publications 2010

Bernado P and Blackledge M
Structural biology : Proteins in dynamic equilibrium.
Nature (2010) 468(7327) : 1046-1048

Blackledge M
Mapping the conformational mobility of multidomain proteins.
Biophysical Journal (2010) 98(10) : 2043-2044

Gely S, Lowry DF, Bernard C, Jensen MR, Blackledge M, Costanzo S, Bourhis JM, Darbon H, Daughdrill G and Longhi S
Solution structure of the C-terminal X domain of the measles virus phosphoprotein and interaction with the intrinsically disordered C-terminal domain of the nucleoprotein.
Journal of Molecular Recognition (2010) 23(5) : 435-447

Jensen MR, Bernado P, Houben K, Blanchard L, Marion D, Ruigrok RW and Blackledge M
Structural disorder within sendai virus nucleoprotein and phosphoprotein : Insight into the structural basis of molecular recognition.
Protein and Peptide Letters (2010) 17(8) : 952-960

Jensen MR, Salmon L, Nodet G and Blackledge M
Defining conformational ensembles of intrinsically disordered and partially folded proteins directly from chemical shifts.
Journal of the American Chemical Society (2010) 132(4) : 1270-1272

Lewandowski JR, Sein J, Blackledge M and Emsley L
Anisotropic collective motion contributes to nuclear spin relaxation in crystalline proteins.
Journal of the American Chemical Society (2010) 132(4) : 1246-1248

Lewandowski JR, Sein J, Sass HJ, Grzesiek S, Blackledge M and Emsley L
Measurement of site-specific (13)C spin-lattice relaxation in a crystalline protein.
Journal of the American Chemical Society (2010) 132(24) : 8252-8254

Markwick PR, Cervantes CF, Abel BL, Komives EA, Blackledge M and McCammon JA
Enhanced conformational space sampling improves the prediction of chemical shifts in proteins.
_ Journal of the American Chemical Society (2010) 132(4) : 1220-1221

Salmon L, Nodet G, Ozenne V, Yin G, Jensen MR, Zweckstetter M and Blackledge M
NMR characterization of long-range order in intrinsically disordered proteins.
Journal of the American Chemical Society (2010) 132(24) : 8407-8418

Vajpai N, Gentner M, Huang JR, Blackledge M and Grzesiek S
Side-chain chi(1) conformations in urea-denatured ubiquitin and protein G from (3)J coupling constants and residual dipolar couplings.
Journal of the American Chemical Society (2010) 132(9) : 3196-3203

Publications 2009

Bernadó P and Blackledge M
A self-consistent description of the conformational behavior of chemically denatured proteins from NMR and small angle scattering.
Biophysical Journal (2009) 97(10) : 2839-2845

Cho MK, Nodet G, Kim HY, Jensen MR, Bernado P, Fernandez CO, Becker S, Blackledge M and Zweckstetter M
Structural characterization of alpha-synuclein in an aggregation prone state.
Protein Science (2009) 18(9) : 1840-1846

Estrada J, Bernado P, Blackledge M and Sancho J
ProtSA : a web application for calculating sequence specific protein solvent accessibilities in the unfolded ensemble.
BMC Bioinformatics (2009) 10 : 104

Fischer D, Mukrasch MD, Biernat J, Bibow S, Blackledge M, Griesinger C, Mandelkow E and Zweckstetter M
Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules.
Biochemistry (2009) 48(42) : 10047-10055

Gabel F, Jensen MR, Zaccai G and Blackledge M
Quantitative modelfree analysis of urea binding to unfolded ubiquitin using a combination of small angle X-ray and neutron scattering.
Journal of the American Chemical Society (2009) 131(25) : 8769-8771

Lewandowski JR, Sein J, Blackledge M and Emsley L
Anisotropic Collective Motion Contributes to Nuclear Spin Relaxation in Crystalline Proteins.
Journal of the American Chemical Society (2009) 132(4) : 1246-1248

Markwick PR, Bouvignies G, Salmon L, McCammon JA, Nilges M and Blackledge M
Toward a unified representation of protein structural dynamics in solution.
Journal of the American Chemical Society (2009) 131(46) : 16968-16975

Markwick PR, Showalter SA, Bouvignies G, Bruschweiler R and Blackledge M
Structural dynamics of protein backbone phi angles : extended molecular dynamics simulations versus experimental (3) J scalar couplings.
Journal of Biomolecular NMR (2009) 45(1-2) : 17-21

Nodet G, Salmon L, Ozenne V, Meier S, Jensen MR and Blackledge M
Quantitative description of backbone conformational sampling of unfolded proteins at amino acid resolution from NMR residual dipolar couplings.
Journal of the American Chemical Society (2009) 131(49) : 17908-17918

Ortega-Roldan JL, Jensen MR, Brutscher B, Azuaga AI, Blackledge M and van Nuland NA
Accurate characterization of weak macromolecular interactions by titration of NMR residual dipolar couplings : application to the CD2AP SH3-C:ubiquitin complex.
Nucleic Acids Research (2009) 37(9) : e70

Ringkjøbing-Jensen M, Markwick PRL, Meier S, Griesinger C, Zweckstetter M, Grzesiek S, Bernadó P and Blackledge M
Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings.
Structure (2009) 17(9) : 1169-1185

Salmon L, Bouvignies G, Markwick P, Lakomek N, Showalter S, Li DW, Walter K, Griesinger C, Bruschweiler R and Blackledge M
Protein conformational flexibility from structure-free analysis of NMR dipolar couplings : quantitative and absolute determination of backbone motion in ubiquitin.
Angewandte Chemie International Edition England (2009) 48(23) : 4154-4157

Publications 2008

Bouvignies G, Markwick PR and Blackledge M
Characterization of protein dynamics from residual dipolar couplings using the three dimensional Gaussian axial fluctuation model. restaurants.
Proteins (2008) 71(1) : 353-363

Hus JC, Salmon L, Bouvignies G, Lotze J, Blackledge M and Bruschweiler R
16-fold degeneracy of peptide plane orientations from residual dipolar couplings : Analytical treatment and implications for protein structure determination.
Journal of the American Chemical Society (2008) 130(47) : 15927-15937

Jensen MR and Blackledge M
On the origin of NMR dipolar waves in transient helical elements of partially folded proteins.
Journal of the American Chemical Society (2008) 130(34) : 11266-11267

Jensen MR, Houben K, Lescop E, Blanchard L, Ruigrok RW and Blackledge M
Quantitative conformational analysis of partially folded proteins from residual dipolar couplings : application to the molecular recognition element of Sendai virus nucleoprotein.
Journal of the American Chemical Society (2008) 130(25) : 8055-8061

Meier S, Blackledge M and Grzesiek S
Conformational distributions of unfolded polypeptides from novel NMR techniques.
Journal of Chemical Physics (2008) 128(5) : 052204

Mylonas E, Hascher A, Bernado P, Blackledge M, Mandelkow E and Svergun DI
Domain conformation of tau protein studied by solution small-angle X-ray scattering.
Biochemistry (2008) 47(39) : 10345-10353

Ribeiro EA, Favier A, Gerard FCA, Leyrat C, Brutscher B, Blondel D, Ruigrok RW, Blackledge M and Jamin M
Solution structure of the C-terminal nucleoprotein-RNA binding domain of the vesicular stomatitis virus phosphoprotein.
Journal of Molecular Biology (2008) 382(2) : 525-538

Wells M, Tidow H, Rutherford TJ, Markwick P, Jensen MR, Mylonas E, Svergun DI, Blackledge M and Fersht AR
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.
Proceedings of the National Academy of Sciences U S A (2008) 105(15) : 5762-5767

Publications 2007

Bernado P, Mylonas E, Petoukhov MV, Blackledge M and Svergun DI
Structural characterization of flexible proteins using small-angle X-ray scattering.
Journal of the American Chemical Society (2007) 129(17) : 5656-5664

Boudet J, Duval V, Van Melckebeke H, Blackledge M, Amoroso A, Joris B and Simorre JP
Conformational and thermodynamic changes of the repressor/DNA operator complex upon monomerization shed new light on regulation mechanisms of bacterial resistance against beta-lactam antibiotics.
Nucleic Acids Research (2007) 35(13) : 4384-4395

Bouvignies G, Markwick PR and Blackledge M
Simultaneous definition of high resolution protein structure and backbone conformational dynamics using NMR residual dipolar couplings.
Chemphyschem (2007) 8(13) : 1901-1909

Cho MK, Kim HY, Bernado P, Fernandez CO, Blackledge M and Zweckstetter M
Amino acid bulkiness defines the local conformations and dynamics of natively unfolded alpha-synuclein and tau.
Journal of the American Chemical Society (2007) 129(11) : 3032-3033

Giraud N, Blackledge M, Bockmann A and Emsley L
The influence of nitrogen-15 proton-driven spin diffusion on the measurement of nitrogen-15 longitudinal relaxation times.
Journal of Magnetic Resonance (2007) 184(1) : 51-61

Houben K, Blanchard L, Blackledge M and Marion D
Intrinsic dynamics of the partly unstructured PX domain from the Sendai virus RNA polymerase co-factor P.
Biophysical Journal (2007) 93(8) : 2830-2844

Markwick PR, Bouvignies G and Blackledge M
Exploring multiple timescale motions in protein GB3 using accelerated molecular dynamics and NMR spectroscopy.
Journal of the American Chemical Society (2007) 129(15) : 4724-4730

Meier S, Grzesiek S and Blackledge M
Mapping the conformational landscape of urea-denatured ubiquitin using residual dipolar couplings.
Journal of the American Chemical Society (2007) 129(31) : 9799-9807

Meier S, Strohmeier M, Blackledge M and Grzesiek S
Direct observation of dipolar couplings and hydrogen bonds across a beta-hairpin in 8 M urea.
Journal of the American Chemical Society (2007) 129(4) : 754-755

Mukrasch MD, Markwick P, Biernat J, Bergen M, Bernado P, Griesinger C, Mandelkow E, Zweckstetter M and Blackledge M
Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation.
Journal of the American Chemical Society (2007) 129(16) : 5235-5243

Sein J, Giraud N, Blackledge M and Emsley L
The role of (15)N CSA and CSA/dipole cross-correlation in (15)N relaxation in solid proteins.
Journal of Magnetic Resonance (2007) 168(1) : 26-33

Publications 2006

Bernado P, Blackledge M and Sancho J
Sequence-specific solvent accessibilities of protein residues in unfolded protein ensembles.
Biophysical Journal (2006) 91(12) : 4536-4543

Bouvignies G, Markwick P, Bruschweiler R and Blackledge M
Simultaneous determination of protein backbone structure and dynamics from residual dipolar couplings.
Journal of the American Chemical Society (2006) 128(47) : 15100-15101

Bouvignies G, Meier S, Grzesiek S and Blackledge M
Ultrahigh-resolution backbone structure of perdeuterated protein GB1 using residual dipolar couplings from two alignment media.
Angewandte Chemie International Edition (2006) 45(48) : 8166-8169

Dames SA, Aregger R, Vajpai N, Bernado P, Blackledge M and Grzesiek S
Residual dipolar couplings in short peptides reveal systematic conformational preferences of individual amino acids.
Journal of the American Chemical Society (2006) 128(41) : 13508-13514

Giraud N, Sein J, Pintacuda G, Bockmann A, Lesage A, Blackledge M and Emsley L
Observation of heteronuclear overhauser effects confirms the N-15-H-1 dipolar relaxation mechanism in a crystalline protein.
Journal of the American Chemical Society (2006) 128(38) : 12398-12399

Reinscheid UM, Farjon J, Radzom M, Haberz P, Zeeck A, Blackledge M and Griesinger C
Effect of the solvent on the conformation of a depsipeptide : NMR-derived solution structure of hormaomycin in DMSO from residual dipolar couplings in a novel DMSO-compatible alignment medium.
Chembiochem (2006) 7(2) : 287-296

Skora L, Cho MK, Kim HY, Fernandez C, Blackledge M and Zweckstetter M
Charge-induced molecular alignment of intrinsically disordered proteins.
Angewandte Chemie International Edition (2006) 45 : 7012-7015

Publications 2005

Bernado P, Bertoncini CW, Griesinger C, Zweckstetter M and Blackledge M
Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings.
Journal of the American Chemical Society (2005) 127(51) : 17968-17969

Bernado P, Blanchard L, Timmins P, Marion D, Ruigrok RW and Blackledge M
A structural model for unfolded proteins from residual dipolar couplings and small-angle x-ray scattering.
Proceedings of the National Academy of Sciences U S A (2005) 102(47) : 17002-17007

Blackledge M
Recent progress in the study of biomolecular structure and dynamics in solution from residual dipolar couplings.
Progress in Nuclear Magnetic Resonance Spectroscopy (2005) 46(1) : 23-61

Bouvignies G, Bernado P and Blackledge M
Protein backbone dynamics from N-HN dipolar couplings in partially aligned systems : a comparison of motional models in the presence of structural noise.
Journal of Magnetic Resonance (2005) 173(2) : 328-338

Bouvignies G, Bernado P, Meier S, Cho K, Grzesiek S, Bruschweiler R and Blackledge M
Identification of slow correlated motions in proteins using residual dipolar and hydrogen-bond scalar couplings.
Proceedings of the National Academy of Sciences U S A (2005) 102(39) : 13885-13890

Giraud N, Blackledge M, Goldman M, Bockmann A, Lesage A, Penin F and Emsley L
Quantitative analysis of backbone dynamics in a crystalline protein from nitrogen-15 spin-lattice relaxation.
Journal of the American Chemical Society (2005) 127(51) : 18190-18201

Sibille N, Blackledge M, Brutscher B, Coves J and Bersch B
Solution structure of the sulfite reductase flavodoxin-like domain from Escherichia coli.
Biochemistry (2005) 44(25) : 9086-9095.

Publications 2004

Bernado P and Blackledge M
Anisotropic small amplitude peptide plane dynamics in proteins from residual dipolar couplings.
Journal of the American Chemical Society (2004) 126(15) : 4907-4920

Bernadó P and Blackledge M
Local dynamic amplitudes on the protein backbone from dipolar couplings : toward the elucidation of slower motions in biomolecules.
Journal of the American Chemical Society (2004) 126(25) : 7760 - 1761

Blanchard L, Tarbouriech N, Blackledge M, Timmins P, Burmeister WP, Ruigrok RWH and Marion D
Structure and dynamics of the nucleocapsid-binding domain of the Sendai virus phosphoprotein in solution.
Virology (2004) 319(2) : 201-211

Bouvignies G, Bernado P and Blackledge M
Modélisation de la dynamique de la chaîne peptidique des protéines en solution par RMN à travers les couplages dipolaires residuels.
Journal de Physique IV (2005) 130 : 229-244

Giraud N, Böckmann A, Lesage A, Penin F, Blackledge M and Emsley L
Site-specific backbone dynamics from a crystalline protein by solid-state NMR spectroscopy.
Journal of the American Chemical Society (2004) 126(37) : 11422 - 11423