Institut de Biologie StructuraleGrenoble / France


A new antifungal therapeutic strategy

Invasive fungal infections cause significant mortality, with 800,000 deaths a year. A collaborative consortium * between three research institutes in Grenoble, the Pasteur Institute and the University of Southern California has discovered that the Bdf1 protein, member of an ubiquitous family of factors regulating gene expression, is essential to the survival of pathogenic fungi. They have identified specific inhibitors of this protein capable of killing yeast. This work, published on May 18, 2017 in the journal Nature Communications, opens high hopes for the development of a new class of antifungal drugs.(Details in french)

* Team Petosa (Institut de Biologie Structurale), Jérôme Govin (Institut de Biosciences et Biotechnologies de Grenoble), Muriel Cornet (TIMC-IMAG-TheREx, CHU Grenoble Alpes), Christophe d’Enfert (Institut Pasteur) and Charles McKenna (University of Southern California, Los Angeles).

Selective BET bromodomain inhibition as an antifungal therapeutic strategy. Mietton F, Ferri E, Champleboux M, Zala N, Maubon D, Zhou Y, Harbut M, Spittler D, Garnaud C, Courçon M, Chauvel M, d’Enfert C, Kashemirov BA, Hull M, Cornet M, McKenna CE, Govin J, Petosa C. Nature Communications 8:15482.

Insights into a mechanism which inhibits root cell elongation

The Methods and Electron Microscopy group in collaboration with the Laboratoire de Biologie végétale et microbiologie environnementales Cadarache and the Leibniz Institute of Plant Biochemistry have revealed a mechanism for plant root growth arrest during low phosphate availability in soil. These results may improve crop plants resistance in acidic soil or depleted in phosphate, or increase their pollutant metal extraction properties. The results of this study were published in Nature Communications on May 15, 2017.

Low phosphate activates STOP1-ALMT1 to rapidly inhibit root cell elongation. Balzergue C, Dartevelle T, Godon C, Laugier E, Meisrimler C, Teulon J-M, Creff A, Bissler M, Brouchoud C, Hagège A, Müller J, Chiarenza S, Javot H, Becuwe-Linka N, David P, Péret B, Delannoy E, Thibaud M-C, Armangaud J, Abel S, Pellequer J-L, Nussaume L and Desnos T. Nat. Commun. 8: 15300.

Discovery of the structure of a fundamental particle of chromatin

An international consortium has updated the complete structure of the nucleosome. This work represents a very important advance in the knowledge of the molecular organization of chromatin, which plays an essential role in many nuclear processes, such as gene expression, DNA replication and damaged DNA repair. This study was published in the journal Molecular Cell.

Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1. Jan Bednar, Isabel Garcia-Saez, Ramachandran Boopathi, Amber R. Cutter, Gabor Papai, Anna Reymer, Sajad H. Syed, Imtiaz Nisar Lone, Ognyan Tonchev, Corinne Crucifix, Hervé Menoni, Christophe Papin, Dimitrios A. Skoufias, Hitoshi Kurumizaka, Richard Lavery, Ali Hamiche, Jeffrey J. Hayes, Patrick Schultz, Dimitar Angelov, Carlo Petosa, Stefan Dimitrov. Molecular Cell. Published: May 4, 2017. vol 66. issue 3, p384–397.