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Institut de Biologie StructuraleGrenoble / France

FRM team label for the Viral Replication Machines Group of Marc Jamin

The Viral Replication Machines Group of the IBS has just been certified as FRM team. About 30 french teams are certified by the "Fondation pour la Recherche Médicale" (FRM) each year.
The group will receive € 395 000 financial support from the FRM over 3 years.

What is this project about?
Protein-protein interactions are at the heart of all biological processes, including virus replication, and constitute a large and under-exploited set of therapeutic targets.Various types of interface, called "linear pattern", consisting of short sequences of contiguous amino acids are abundantly used by viruses to assemble their replicative complexes and divert molecular machines from their hosts.his project aims to: (1) characterize protein-protein interactions involving an interface of this type within the replicative machine of various viruses or host-virus interactions, (2) demonstrate that peptides mimicking these interfaces block replication of these viruses and (3) optimize these peptides by combinatorial methods of directed evolution in order to increase their affinity or to extend their spectrum of activity.