Institut de Biologie StructuraleGrenoble / France

2006

Crystal structure of HIV-1 protease product complex

Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates

Proceedings of the National Academy of Sciences U S A (2006) 103(49): 18469 -

Das A, Prashar V, Mahale S, Serre L, Ferrer JL, Hosur MV.

Ultra-high resolution protein structure in solution from residual dipolar couplings

Ultrahigh-resolution backbone structure of perdeuterated Ppotein GB1 using residual dipolar couplings from two alignment media.

Angewandte Chemie International Edition (2006) 45(48): 8166-8169

Bouvignies G, Meier S, Grzesiek S and Blackledge M

Simultaneous Determination of Protein Backbone Structure and Dynamics from Residual Dipolar Couplings

J. Am. Chem. Soc.; 2006; 128; 15100-15101.

Bouvignies, G.; Markwick, P.; Bruschweiler, R.; Blackledge, M.

’Fête de la Science’2006 at the IBS

The 15th edition of the Science Week took place from the 6th to the 15th of October, 2006.

For this fifteen edition the Institute welcomed the general public (adults and secondary school pupils). The visit varied from 30mn to 2 hours according to visitors. Topics : Biology, Chemistry, Medicine, Physics

For more details about the Science Week, please have a look to the :
- nofficial web site of the "Science Week" (in french only)

Explications sur les apports de l’Enzymologie dans la lutte contre le cancer
Expo photos des 50 ans du CEA, l’une des tutelles de l’IBS
Préparation d’un échantillon de protéine
Préparation d’un gel d’electrophorèse
Présentation de la Résonnance Magnétique Nucléaire aux élèves de 1ere
Introduction à la Biologie Moléculaire avec RobioMol

Residual dipolar couplings in short peptides reveal systematic conformational preferences of individual amino acids

Journal of the American Chemical Society (2006) 128(41): 13508-13514

Dames SA, Aregger R, Vajpai N, Bernado P, Blackledge M and Grzesiek S

Charge-Induced Molecular Alignment of Intrinsically Disordered Proteins

Angew Chem Int Ed Engl.2006 Oct 27;45(42):7012-5
Skora L, Cho M-K, Kim H-Y, Becker S, Fernandez C, Blackledge M, Zweckstetter M

Structural basis for the inhibition of HMG synthase by the natural product F244

Structural basis for the covalent inhibition of 3-hydrox-3-methylglutaryl-coenzyme A synthase by the b-lactone containing natural product F244.

Proceedings of the National Academy of Sciences U S A (2006) 103(31): 11491-11496

Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ and Noel JP

PBPs, molecules of interest for drug-design

Penicillin Binding Proteins: key players in bacterial cell cycle and drug resistance processes.

FEMS Microbiology Reviews (2006) 30(5): 673-691

Macheboeuf P, Contreras-Martel C, Job V, Dideberg O and Dessen A

Functional flexibility of B. stearothermophilus formamidopyrimidine DNA-glycosylase

Functional flexibility of Bacillus stearothermophilus formamidopyrimidine DNA-glycosylase

DNA Repair (2006) 5(8): 947-958

Amara P and Serre L

A comparative QM/MM simulation study of the reaction mechanisms of human and Plasmodium falciparum HG(X)PRTases

Journal of the American Chemical Society /(2006) 128(31): 10096-10102

Thomas A and Field MJ

Structure of allosteric Aspartate kinase

Press release (in french only)

A Novel Organization of ACT Domains in Allosteric Enzymes Revealed by the Crystal Structure of Arabidopsis Aspartate Kinase

C. Mas-Droux, G. Curien, M. Robert-Genthon, M. Laurencin1, J.-L. Ferrer, and R. Dumas

Plant Cell. 2006 Jul;18(7):1681-1692.

Relations Between Structure and Function of the Mitochondrial ADP/ATP Carrier

Relations Between Structure and Function of the Mitochondrial ADP/ATP Carrier

Annual Review of Biochemistry Volume 75: 713-74 75

Nury H, Dahout-Gonzalez C, Trezeguet V, Lauquin GJ, Brandolin G, Pebay-Peyroula E.

CNRS Silver Medal awarded to E.Pebay-Peyroula

Friday June 9, 2006 (IBS seminar room, 4 pm ): Eva Pebay-Peyroula, Professor at Joseph Fourier University and Director of the Institute of Structural Biology, received one of the CNRS’s 2005 Silver Medals.

CNRS Silver Medals distinguish researchers who have performed original and important research that is recognized nationally and internationally. About fifteen medals are awarded annually.

C1q recognizes C-reactive protein through its globular domain

Evidence that complement protein C1q interacts with C-reactive protein through its globular head region.

Journal of Immunology (2006) 176(5): 2950-2957

McGrath FD, Brouwer MC, Arlaud GJ, Daha MR, Hack CE and Roos A

STLC, a reversible, tight binding inhibitor of the human kinesin Eg5

S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

Journal of Biological Chemistry (2006) 281: 17559-17569

Skoufias DA, Debonis S, Saoudi Y, Lebeau L, Crevel I, Cross R, Wade RH, Hackney D and Kozielski F

Structural insights into substrate traffic and inhibition in acetylcholinesterase

Structural insights into substrate traffic and inhibition in acetylcholinesterase.
EMBO J. 2006 Jun 8
Colletier JP, Fournier D, Greenblatt HM, Stojan J, Sussman JL, Zaccai G, Silman I, Weik M.
Conformational Flexibility in the Peripheral Site of Torpedo californica Acetylcholinesterase Revealed by the Complex Structure with a Bifunctional Inhibitor
J Am Chem Soc. 2006 Apr 12
Colletier JP, Sanson B, Nachon F, Gabellieri E, Fattorusso C, Campiani G, Weik M.

High speed three-dimensional protein NMR

Speeding up three-dimensional protein NMR experiments to a few minutes.

Journal of the American Chemical Society (2006) 128(28): 9042-9043

Schanda P, Van Melckebeke H and Brutscher B

Serendipitous discovery and x-ray structure of a human phosphate binding apolipoprotein

Serendipitous discovery and x-ray structure of a human phosphate binding apolipoprotein.
Structure. 2006 Mar;14(3):601-9.

Morales R, Berna A, Carpentier P, Contreras-Martel C, Renault F, Nicodeme M, Chesne-Seck ML, Bernier F, Dupuy J, Schaeffer C, Diemer H, Van-Dorsselaer A, Fontecilla-Camps JC, Masson P, Rochu D, Chabriere E.

Flexibility of Thiamine Diphosphate in pyruvate oxidoreductase

Flexibility of Thiamine Diphosphate Revealed by Kinetic Crystallographic Studies of the Reaction of Pyruvate-Ferredoxin Oxidoreductase with Pyruvate
Structure, Volume 14, Issue 2, 2 February 2006, Pages 217-224
Christine Cavazza, Carlos Contreras-Martel, Laetitia Pieulle, Eric Chabrière, E. Claude Hatchikian and Juan C. Fontecilla-Camps

Shared architecture of bacteriophage SPO1 and herpesvirus capsids

Shared architecture of bacteriophage SPO1 and herpesvirus capsids
Current Biology, Volume 16, Issue 1, 10 January 2006, Pages R11-R13
Robert L. Duda, Roger W. Hendrix, Wai Mun Huang and James F. Conway

ICarl-Ivar-Brändén Building inauguration

A major European Centre for Structural Biology inaugurated in Grenoble

Friday January 13, 2006 from 1:30 to 3:30 p.m.

ESRF Auditorium - 6 rue Jules Horowitz – Grenoble – France

- Press release

- more information about this building, the PSB and the IVMS

Crystal Structure of Human Iron Regulatory Protein 1 as Cytosolic Aconitase

Crystal Structure of Human Iron Regulatory Protein 1 as Cytosolic Aconitase

Structure, Volume 14, Issue 1, January 2006, Pages 129-139
Jérôme Dupuy, Anne Volbeda, Philippe Carpentier, Claudine Darnault, Jean-Marc Moulis and Juan Carlos Fontecilla-Camps

Crystal structure of iron regulatory protein 1 complexed with ferritin IRE-RNA.

Science 2006, 314, 1903-1908
Walden, W. E.; Selezneva, A. I.; Dupuy, J.; Volbeda, A.; Fontecilla-Camps, J. C.; Theil, E. C.; Volz, K.