Institut de Biologie StructuraleGrenoble / France

Malene Ringkjøbing Jensen is the recipient of the CNRS bronze medal

Malene Ringkjøbing Jensen (IBS/FDP) is the recipient of a bronze medal of the CNRS 2015. This distinction rewards an on-going and fruitful research activity, which makes him/her a specialist with talent within a particular research field.

The research of Malene Jensen focuses on intrinsically disordered proteins, a class of proteins that remain functional despite the lack of a well-defined three-dimensional structure. Numerous intrinsically disordered proteins are associated with human diseases and Malene aims to elucidate the molecular mechanisms controlling the function of these proteins in order to potentially propose novel pharmacological solutions.
After obtaining her Ph.D. in 2006 at the Department of Chemistry, University of Copenhagen, she joined the group of Dr. Martin Blackledge (Protein Dynamics and Flexibility) at the Institut de Biologie Structurale (IBS) in Grenoble as a postdoctoral fellow. She was recruited by the CNRS in 2009 in order to continue her research activities at the IBS. Malene Jensen mainly uses nuclear magnetic resonance (NMR) spectroscopy in solution that provides information at atomic resolution about the structure and dynamics of proteins. In particular, NMR provides detailed insight into the conformational behaviour of disordered proteins and their interactions with physiological partners. Using experimental data from NMR in combination with computational methods, Malene Jensen has been able to contribute to the understanding of the role played by disordered proteins in the transcription and replication machinery of Measles virus as well as other members of the Paramyxoviridae family. Currently, her research focuses on understanding how intrinsically disordered proteins contribute to signalling specificity in the mitogen-activated protein kinase (MAPK) cell signalling pathways.