Institut de Biologie StructuraleGrenoble / France

Kinetics and RNA sequence dependence of measles virus nucleocapsid

Measles virus RNA genomes are packaged into helical nucleocapsids (NCs), comprising thousands of nucleo-proteins (N) that bind the entire genome. N-RNA provides the template for replication and transcription by the viral polymerase and is a promising target for viral inhibition. The nucleocapsid assembly process regulating this process has been described for the first time by IBS researchers thanks to a combination of real-time NMR, fluorescence spectroscopy and electron microscopy. This observation is reported in Angewandte Chemie on June 06. Press release-(in french only)

Self-assembly of measles virus nucleocapsid-like particles: Kinetics and RNA sequence dependence. Sigrid Milles, Malene Ringkjøbing Jensen, Guillaume Communie, Damien Maurin, Guy Schoehn, Rob W.H. Ruigrok and Martin Blackledge. Angewandte Chemie, 30 May 2016