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Institut de Biologie StructuraleGrenoble / France

Publications since 2014

Our list of publications with peerReviewing, books and book sections since 2014 can be found below (data issued from HAL-IBS). The display may take 1 to 2 seconds. To check the entire list, use the inner scroll bar.

The list of publications from 2000 to 2013 is displayed at the bottom of the page.

Publications until 2013

Publications 2013

Favini-Stabile S, Contreras-Martel C, Thielens N and Dessen A
MreB and MurG as scaffolds for the cytoplasmic steps of peptidoglycan biosynthesis.
Environmental Microbiology (2013) 15(12) : 3218-3228

Hrast M, Turk S, Sosič I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O’Neill AJ, Mengin-Lecreulx D, Blanot D and Gobec S
Structure–activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.
European Journal of Medicinal Chemistry (2013) 66 : 32-45

Lombardi C, Ayach M, Beaurepaire L, Chenon M, Andreani J, Guerois R, Jupin I and Bressanelli S
A compact viral processing proteinase/ubiquitin hydrolase from the OTU family.
PLoS Pathogens (2013) 9(8) : e1003560

Neves D, Job V, Dortet L, Cossart P and Dessen A
Structure of Internalin InlK from the Human Pathogen Listeria monocytogenes.
Journal of Molecular Biology (2013) 425(22) : 4520–4529

Ruane KM, Lloyd AJ, Fulop V, Dowson CG, Barreteau H, Boniface A, Dementin S, Blanot D, Mengin-Lecreulx D, Gobec S, Dessen A and Roper DI
Specificity determinants for lysine incorporation in Staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex.
Journal of Biological Chemistry (2013) 288(46) : 33439-33448

Tosi T, Pflug A, Discola KF, Neves D and Dessen A
Structural basis of eukaryotic cell targeting by type III secretion system (T3SS) effectors.
Research in Microbiology (2013) 164(6) : 605-619

Publications 2012

El Mortaji L, Contreras-Martel C, Moschioni M, Ferlenghi I, Manzano C, Vernet T, Dessen A and Di Guilmi AM
The full-length Streptococcus pneumoniae major pilin RrgB crystallizes in a fiber-like structure, which presents the D1 isopeptide bond and provides details on the mechanism of pilus polymerization.
Biochemical Journal (2012) 441(3) : 833-841

Gendrin C, Contreras-Martel C, Bouillot S, Elsen S, Lemaire D, Skoufias DA, Huber P, Attree I and Dessen A
Structural basis of cytotoxicity mediated by the type III secretion toxin exoU from Pseudomonas aeruginosa.
PLoS Pathogens (2012) 8(4) : e1002637

Hrast M, Turk S, Sosič I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O’Neill AJ, Mengin-Lecreulx D, Blanot D and Gobec S
Structure–activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.
European Journal of Medicinal Chemistry (2013) 66 : 32-45

Inglis SR, Strieker M, Rydzik AM, Dessen A and Schofield CJ
A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and beta-lactamases.
Analytical Biochemistry (2012) 420(1) : 41-47

Neves D and Dessen A
Microbiology : sensing stability.
Nature Chemical Biology (2012) 8(8) : 681-682

Neves D, Estrozi LF, Job V, Gabel F, Schoehn G and Dessen A
Conformational states of a bacterial alpha(2)-macroglobulin resemble those of human complement C3.
PLoS One (2012) 7(4) : e35384

Nikolaidis I, Izore T, Job V, Thielens N, Breukink E and Dessen A
Calcium-dependent complex formation between PBP2 and lytic transglycosylase SltB1 of Pseudomonas aeruginosa.
Microbial Drug Resistance (2012) 18(3) : 298-305

Tomašić T, Šink R, Zidar N, Fic A, Contreras-Martel C, Dessen A, Patin D, Blanot D, Müller-Premru M, Gobec S, Zega A, Kikelj D and Mašič LP
Dual inhibitor of MurD and MurE ligases from escherichia coli and staphylococcus aureus.
ACS Medicinal Chemistry Letters (2012) 3(8) : 626-630

Publications 2011

Contreras-Martel C, Amoroso A, Woon EC, Zervosen A, Inglis S, Martins A, Verlaine O, Rydzik AM, Job V, Luxen A, Joris B, Schofield CJ and Dessen A
Structure-guided design of cell wall biosynthesis inhibitors that overcome beta-Lactam resistance in Staphylococcus aureus (MRSA).
ACS Chemical Biology (2011) 6 (9) : 943-951

Contreras Martel C, El Mortaji L, Manzano C, Terrasse R, Vernet T, Di Guilmi AM and Dessen A
Structural basis of host cell recognition by the pilus adhesin from Streptococcus pneumonia.
Structure (2011) 18 (1) : 106-115

El Ghachi M, Mattei PJ, Ecobichon C, Martins A, Hoos S, Schmitt C, Colland F, Ebel C, Prevost MC, Gabel F, England P, Dessen A and Boneca IG
Characterization of the elongasome core PBP2 : MreC complex of Helicobacter pylori.
Molecular Microbiology (2011) 82 (1) : 68-86

Inglis SR, Strieker M, Rydzik AM, Dessen A and Schofield CJ
A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases.
Analytical Biochemistry (2011) 420 : 41-47

Izoré T, Job V and Dessen A
Biogenesis, regulation, and targeting of the type III secretion system.
Structure (2011) 19 (5) : 603-612

Izoré T, Perdu C, Job V, Atree I, Faudry E and Dessen A
Structural characterization and membrane localization of ExsB from the type III secretion system (T3SS) of Pseudomonas aeruginosa.
Journal of Molecular Biology (2011) 413 (1) : 236-246

Lebreton A, Lakisic G, Job V, Fritsch L, Tham TN, Camejo A, Mattei PJ, Regnault B, Nahori MA, Cabanes D, Gautreau A, Ait-Si-Ali S, Dessen A, Cossart P and Bierne H
A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response.
Science (2011) 331 (6022) : 1319-1321

Macheboeuf P, Piuzzi M, Finet S, Bontems F, Pérez J, Dessen A and Vachette P
Solution X-ray scattering study of a full-length class A penicillin-binding protein.
Biochemical and Biophysical Research Communications (2011) 405 (1) : 107-111

Mattei PJ, Faudry E, Job V, Izore T, Attree I and Dessen A
Membrane targeting and pore formation by the type III secretion system translocon.
FEBS Journal (2011) 278(3) : 414-426

Nickerson NN, Tosi T, Dessen A, Baron B, Raynal B, England P and Pugsley AP
Outer membrane targeting of secretin PulD relies on disordered domain recognition by a dedicated chaperone.
Journal of Biological Chemistry (2011) 286 (45) : 38833-38843

Sosic I, Barreteau H, Simcic M, Roman S, Cesar J, Zega A, Golic Grdadolnik S, Contreras-Martel C, Dessen A, Amoroso A, Joris B, Blanot D and Gobec S
Second-generation sulfonamide inhibitors of Dglutamic acid-adding enzyme : activity optimisation with conformationally rigid analogues of dglutamic acid.
European Journal of Medicinal Chemistry (2011) 46 (7) : 2880-2894

Szeto TH, Dessen A and Pelicic V
Structure/function analysis of Neisseria meningitidis PilW, a conserved protein that plays multiple roles in type IV pilus biology.
Infection and Immunity (2011) 79 (8) : 3028-3035

Tomašić T, Zidar N, Šink R, Kovač A, Blanot D, Contreras-Martel C, Dessen A, Müller-Premru M, Zega A, Gobec S, Kikelj D and Peterlin Mašič L
Structure-based design of a new series of d-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-l-alanine : D-glutamate ligase (MurD).
Journal of Medicinal Chemistry (2011) 54 (13) : 4600-4610

Tosi T, Nickerson NN, Mollica L, Jensen MR, Blackledge M, Baron B, England P, Pugsley AP and Dessen A
Pilotin-secretin recognition in the type II secretion system of Klebsiella oxytoca.
Molecular Microbiology (2011) 82 (6) : 1422-1432

Publications 2010

Aschtgen MS, Gavioli M, Dessen A, Lloubes R and Cascales E
The SciZ protein anchors the enteroaggregative Escherichia coli Type VI secretion system to the cell wall.
Molecular Microbiology (2010) 75(4) : 886-899.

Dessen A and Xu W
Structural biology of protein functional regulation.
Current Opinion in Structural Biology (2010) 20(6) : 711-713

El Mortaji L, Terrasse R, Dessen A, Vernet T and Di Guilmi AM
Stability and assembly of pilus subunits of streptococcus pneumoniae.
Journal of Biological Chemistry (2010) 285(16) : 12405-12415.

Gendrin C, Sarrazin S, Bonnaffe D, Jault JM, Lortat-Jacob H and Dessen A
Hijacking of the pleiotropic cytokine interferon-gamma by the type III secretion system of Yersinia pestis.
PLoS One (2010) 5(12) : e15242

Izoré T, Contreras-Martel C, El Mortaji L, Manzano C, Terrasse R, Vernet T, Di Guilmi AM and Dessen A
Structural basis of host cell recognition by the pilus adhesin from Streptococcus pneumoniae.
Structure (2010) 18(1) : 106-115.

Job V, Mattei PJ, Lemaire D, Attree I and Dessen A
Structural basis of chaperone recognition of type III secretion system minor translocator proteins.
Journal of Biological Chemistry (2010) 285(30) : 23224-23232.

Matteï P-J, Neves D and Dessen A
Bridging cell wall biosynthesis and bacterial morphogenesis.
Current Opinion in Structural Biology (2010) 20(6) : 749-755

Ple S, Job V, Dessen A and Attree I
Co-chaperone interactions in export of the type III needle component PscF of Pseudomonas aeruginosa
Journal of Bacteriology (2010) 192(14) : 3801-3808.

Zidar N, Tomasic T, Sink R, Rupnik V, Kovac A, Turk S, Patin D, Blanot D, Contreras Martel C, Dessen A, Muller Premru M, Zega A, Gobec S, Peterlin Masic L and Kikelj D
Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligase.
Journal of Medicinal Chemistry (2010) 53(18) : 6584-6594

Publications 2009

Contreras-Martel C, Dahout-Gonzalez C, Martins Ados S, Kotnik M and Dessen A
PBP active site flexibility as the key mechanism for beta-lactam resistance in pneumococci.
Journal of Molecular Biology (2009) 387(4) : 899-909.

Manzano C, Izore T, Job V, Di Guilmi AM and Dessen A
Sortase activity is controlled by a flexible lid in the pilus biogenesis mechanism of gram-positive pathogens.
Biochemistry (2009) 48(44) : 10549-10557.

Neiers F, Madhurantakam C, Fälker S, Manzano C, Dessen A, Normark S, Henriques-Normark B and Achour A
Two crystal structures of Pneumococcal pilus sortase C provide novel insights into catalysis and substrate specificity.
Journal of Molecular Biology (2009) 393 : 704-716.

Publications 2008

Manzano C, Contreras-Martel C, El Mortaji L, Izoré T, Fenel D, Vernet T, Schoehn G, Di Guilmi AM, Dessen A
_Sortase-mediated pilus fiber biogenesis in Streptococcus pneumoniae.
Structure (2008) Dec 10 ;16(12):1838-48.

Diemer H, Elias M, Renault F, Rochu D, Contreras-Martel C, Schaeffer C, Van Dorsselaer A and Chabriere E
Tandem use of X-ray crystallography and mass spectrometry to obtain ab initio the complete and Journal of Molecular Biology (2008) 378(5) : 1031-1039
exact amino acids sequence of HPBP, a human 38-kDa apolipoprotein.
Proteins (2008) 71(4) : 1708-1720

Humljan J, Kotnik M, Contreras-Martel C, Blanot D, Urleb U, Dessen A, Solmajer T and Gobec S
Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme.
J Med Chem (2008) 51(23) : 7486-7494

Job V, Carapito R, Vernet T, Dessen A and Zapun A
Common alterations in PBP1a from resistant Streptococcus pneumoniae decrease its reactivity toward beta-lactams : STRUCTURAL INSIGHTS.
Journal of Biological Chemistry (2008) 283(8) : 4886-4894

Macheboeuf P, Lemaire D, Dos Santos Martins A, Dideberg O, Jamin M and Dessen A
Trapping of an acyl-enzyme intermediate in a Penicillin-Binding Protein (PBP)-catalyzed reaction.
Journal of Molecular Biology (2008) 276(2) : 405-413

Trindade MB, Job V, Contreras-Martel C, Pelicic V and Dessen A
Structure of a widely conserved type IV pilus biogenesis factor that affects the stability of secretin multimers.
Molecular Biology (2008) 378(5):1031-1039

Publications 2007

Contreras-Martel C, Matamala A, Bruna C, Poo-Caamano G, Almonacid D, Figueroa M, Martinez-Oyanedel J and Bunster M
The structure at 2 A resolution of Phycocyanin from Gracilaria chilensis and the energy transfer network in a PC-PC complex.
Biophysical Chemistry (2007) 125(2-3) : 388-396

Faudry E, Job V, Dessen A, Attree I and Forge V
Type III secretion system translocator has a molten globule conformation both in its free and chaperone-bound forms.
Febs Journal (2007) 274(14) : 3601-3610

Kotnik M, Humljan J, Contreras-Martel C, Oblak M, Kristan K, Herve M, Blanot D, Urleb U, Gobec S, Dessen A and Solmajer T
Structural and functional characterization of enantiomeric glutamic acid derivatives as potential transition state analogue inhibitors of MurD ligase.
Journal of Molecular Biology (2007) 370(1) : 107-115

Macheboeuf P, Fischer DS, Brown T, Jr., Zervosen A, Luxen A, Joris B, Dessen A and Schofield CJ
Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins.
Nature Chemical Biology (2007) 3(9) : 565-569

Morales R, Berna A, Carpentier P, Contreras-Martel C, Renault F, Nicodeme M, Chesne-Seck ML, Bernier F, Dupuy J, Schaeffer C, Diemer H, Van-Dorsselaer A, Fontecilla-Camps JC, Masson P, Rochu D and Chabriere E
[Discovery and crystallographic structure of human apolipoprotein].
Annales Pharmaceutiques Françaises (2007) 65(2) : 98-107

Quinaud M, Ple S, Job V, Contreras-Martel C, Simorre JP, Attree I and Dessen A
Structure of the heterotrimeric complex that regulates type III secretion needle formation.
Proceedings of the National Academy of Sciences U S A (2007) 104(19) : 7803-7808

Publications 2006

Cavazza C, Contreras-Martel C, Pieulle L, Chabriere E, Hatchikian EC and Fontecilla-Camps JC
Flexibility of thiamine diphosphate revealed by kinetic crystallographic studies of the reaction of pyruvate-ferredoxin oxidoreductase with pyruvate.
Structure (2006) 14(2) : 217-224

Contreras-Martel C, Carpentier P, Morales R, Renault F, Chesne-Seck ML, Rochu D, Masson P, Fontecilla-Camps JC and Chabriere E
Crystallization and preliminary X-ray diffraction analysis of human phosphate-binding protein.
Acta Crystallographica Section F : Structural Biology and Crystallization Communications (2006) 62(Pt 1) : 67-69

Contreras-Martel C, Job V, Di Guilmi AM, Vernet T, Dideberg O and Dessen A
Crystal structure of penicillin-binding protein 1a (PBP1a) reveals a mutational hotspot implicated in beta-lactam resistance in Streptococcus pneumoniae.
Journal of Molecular Biology (2006) 355(4) : 684-696

Macheboeuf P, Contreras-Martel C, Job V, Dideberg O and Dessen A
Penicillin binding proteins : key players in bacterial cell cycle and drug resistance processes.
FEMS Microbiology Reviews (2006) 30(5) : 673-691

Morales R, Berna A, Carpentier P, Contreras-Martel C, Renault F, Nicodeme M, Chesne-Seck ML, Bernier F, Dupuy J, Schaeffer C, Diemer H, Van-Dorsselaer A, Fontecilla-Camps JC, Masson P, Rochu D and Chabriere E
Serendipitous discovery and x-ray structure of a human phosphate binding apolipoprotein.
Structure (2006) 14(3) : 601-609

Publications 2005

Macheboeuf P, di Guilmi AM, Job V, Vernet T, Dideberg O and Dessen A
Active site restructuring regulates ligand recognition in class A penicillin-binding proteins (PBPs).
Proceedings of the National Academy of Sciences U S A (2005) 102(3) : 577-582

Morlot C, Pernot L, Le Gouellec A, di Guilmi AM, Vernet T, Dideberg O and Dessen A
Crystal structure of a peptidoglycan synthesis regulatory factor (PBP3) from Streptococcus pneumoniae.
Journal of Biological Chemistry (2005) 280(16) : 15984-15991

Quinaud M, Chabert J, Faudry E, Neumann E, Lemaire D, Pastor A, Elsen S, Dessen A and Attree I
The PscE-PscF-PscG complex controls type III secretion needle biogenesis in Pseudomonas aeruginosa.
Journal of Biological Chemistry (2005) 280(43) : 36293-36300

Publications 2004

Dessen A
A new catalytic dyad regulates anchoring of molecules to the gram-positive cell wall by sortases.
Structure (Camb) (2004) 12(1) : 6-7

Goure J, Pastor A, Faudry E, Chabert J, Dessen A and Attree I
The V antigen of Pseudomonas aeruginosa is required for assembly of the functional PopB/PopD translocation pore in host cell membranes.
Infection Immunity (2004) 72(8) : 4741 - 4750

Nanao MH, Tcherniuk SO, Chroboczek J, Dideberg O, Dessen A and Balakirev MY
Crystal structure of human otubain 2.
EMBO Reports (2004) 5(8) : 783-788

Pernot L, Chesnel L, Legouellec A, Croize J, Vernet T, Dideberg O and Dessen A
A PBP2x from a clinical isolate of spectrococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibiotics.
Journal of Biological Chemistry (2004) 279 : 16463-16470

Publications 2003

Di Guilmi AM, Dessen A, Dideberg O and Vernet T
Functional characterization of penicillin-binding protein 1b from Streptococcus pneumoniae.
Journal of Bacteriology (2003) 185(5) : 1650-1658.

Di Guilmi AM, Dessen A, Dideberg O and Vernet T
The glycosyltransferase domain of penicillin-binding protein 2a from Streptococcus pneumoniae catalyzes the polymerization of murein glycan chains.
Journal of Bacteriology (2003) 185(15) : 4418-4423

Fokine A, Morales R, Contreras-Martel C, Carpentier P, Renault F, Rochu D and Chabriere E
Direct phasing at low resolution of a protein copurified with human paraoxonase (PON1).
Acta Crystallographica D Biological Crystallography (2003) 59(Pt 12) : 2083-2087

Job V, Di Guilmi AM, Martin L, Vernet T, Dideberg O and Dessen A
Structural studies of the transpeptidase domain of PBP1a from Streptococcus pneumoniae.
Acta Crystallographica D Biological Crystallography (2003) 59(6) : 1067-1069

Molla G, Motteran L, Job V, Pilone MS and Pollegioni L
Kinetic mechanisms of glycine oxidase from Bacillus subtilis.
European Journal of Biochemistry (2003) 270(7) : 1474-1482

Nanao M, Ricard-Blum S, Di Guilmi AM, LeMaire D, Lascoux D, Chabert J, Attree I and Dessen A
Type III secretion proteins PcrV and PcrG from Pseudomonas aeruginosa form a 1:1 complex through high affinity interactions.
BMC Microbiology (2003) 3 : 21

Schoehn G, Di Guilmi AM, Lemaire D, Attree I, Weissenhorn W and Dessen A
Oligomerization of type III secretion proteins PopB and PopD precedes pore.
Embo Journal(2003) 22(19) : 4957-4967

Publications 2002

Boselli A, Sacchi S, Job V, Pilone MS and Pollegioni L
Role of tyrosine 238 in the active site of Rhodotorula gracilis D-amino acid oxidase. A site-directed mutagenesis study.
European Journal of Biochemistry (2002) 269(19) : 4762-4771

Di Guilmi AM and Dessen A
New approaches towards the identification of antibiotic and vaccine targets in Streptococcus pneumoniae.
EMBO Reports (2002) 3(8) : 728-734.

Di Guilmi AM, Dessen A, Dideberg O and Vernet T
Bifunctional penicillin-binding proteins : focus on the glycosyltransferase domain and its specific inhibitor moenomycin.
Current Pharmacology Biotechnology (2002) 3(2) : 63-75.

Job V, Molla G, Pilone MS and Pollegioni L
Overexpression of a recombinant wild-type and His-tagged Bacillus subtilis glycine oxidase in Escherichia coli.
European Journal of Biochemistry (2002) 269(5) : 1456-1463

Publications 2001

Contreras Martel C, Martinez Oyanedel J, Bunster M, Legrand P, Piras C, Vernede X and Fontecilla Camps J C
Crystallization and 2.2 angstrom E resolution structure of R-phycoerythrin from Gracilaria chilensis : a case of perfect hemihedral twinning.
Acta Crystallographica D Biological Crystallography (2001) 57 Part 1 : 52-60

Dessen A, di Guilmi AM, Vernet T and Dideberg O
Molecular mechanisms of antibiotic resistance in Gram-positive pathogens.
Current Drug Targets - Infectious Disorders (2001) 1 : 63-77

Dessen A, Mouz N, Gordon E, Hopkins J and Dideberg O
Crystal Structure of PBP2x from a Highly Penicillin-resistant Streptococcus pneumoniae Clinical Isolate. A MOSAIC FRAMEWORK CONTAINING 83 MUTATIONS.
Journal of Biological Chemistry (2001) 276(48) : 45106-45112.

Publications 2000

Dessen A
Phospholipase A(2) enzymes : structural diversity in lipid messenger metabolism.
Structure Folding & Design (2000) 8(2) : R15-22.

Dessen A
Structure and mechanism of human cytosolic phospholipase A(2).
Biochimica and Biophysica Acta (2000) 1488(1-2) : 40-47.

Dessen A, Forest E, Volchkov V, Dolnik O, Klenk HD and Weissenhorn W
Crystallization and preliminary X-ray analysis of the matrix protein from Ebola virus.
Acta Crystallographica D Biological Crystallography (2000) 56(Pt 6) : 758-760.

Dessen A, Volchkov V, Dolnik O, Klenk HD and Weissenhorn W
Crystal structure of the matrix protein VP40 from Ebola virus.
Embo Journal (2000) 19(16) : 4228-4236.

Molla G, Porrini D, Job V, Motteran L, Vegezzi C, Campaner S, Pilone MS and Pollegioni L
Role of arginine 285 in the active site of Rhodotorula gracilis D-amino acid oxidase. A site-directed mutagenesis study.
Journal of Biological Chemistry (2000) 275(32) : 24715-24721

Ruigrok RW, Schoehn G, Dessen A, Forest E, Volchkov V, Dolnik O, Klenk HD and Weissenhorn W
Structural characterization and membrane binding properties of the matrix protein VP40 of Ebola virus.
Journal of Molecular Biology (2000) 300(1) : 103-112.

Somoza JR, Menon S, Schmidt H, Joseph-McCarthy D, Dessen A, Stahl ML, Somers WS and Sullivan FX
Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme’s catalytic mechanism and regulation by GDP-fucose.
Structure Folding & Design (2000) 8(2) : 123-135.