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Institut de Biologie StructuraleGrenoble / France

Contact person(s) related to this article / BOISBOUVIER Jerome / BRUTSCHER Bernhard / FAVIER Adrien / SCHANDA Paul / Simorre Jean-Pierre

Biomolecular NMR Spectroscopy group

Welcome to the Biomolecular NMR Spectroscopy group.

JPEG


The ability to characterize structure and dynamics of biomolecules (proteins, nucleic acids, sugars), as well as interactions with physiological partners have made NMR an essential tool for understanding biological processes. The study of molecular complexes, even in the case of weak affinity, opens up powerful opportunities for the development of pharmacologically active molecules. The biomolecular NMR group is composed of 4 research teams that develop solution- and solid-state NMR methodologies to answer various biological and biophysical questions, comprising protein folding and chaperoning, mechanisms of enzyme function, and the biogenesis of the cell wall/membranes of bacteria and mitochondria. These biological topics are addressed primarily by NMR spectroscopy methods, but these are complemented whenever possible by other biophysical techniques, in particular SAXS, EM and crystallography, as well as by in vivo/functional experiments, mostly performed through external collaborations.


For more information about our research and job opportunities, please contact one of the team leaders :


Research teams

Please click on the images to get more information
NMR of large Biomolecular Assemblies Bacterial cell wall
Team 1 : NMR of large molecular assemblies Team 2 : Bacterial cell wall
Protein & RNA folding and methods development Solid State NMR and Dynamics
Team 3 : Liquid-state NMR methods Team 4 : Solid state NMR and dynamics


High-field NMR facility, cell-free expression platform, and NMRlib


Our group is in charge of several platforms for high-field NMR spectroscopy and preparation of biological samples for NMR studies. We also develop NMRlib, a user-friendly pulse sequence library for Bruker NMR spectrometers that can be freely downloaded here (link).

Please visit the links below for more information.
1) High-field NMR 2) Cell-free expression 3) NMRlib

Further information of interest

Latest research results {PNG} List of publications {PNG} NMR structure galerie {PNG} Open positions {PNG} Teaching & NMR courses {PNG} ALUMNI {PNG}