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Institut de Biologie StructuraleGrenoble / France

Contact person(s) related to this article / ROSSI Véronique / THIELENS Nicole

Presentation of the "Immune response to pathogens and altered-self" group

Group leader: Nicole Thielens

Group members

Isabelle BALLY (Engineer CEA)
Anne CHOUQUET (Advanced Technician CEA)
Philippe FRACHET (Associate professor UGA PhD)
Christine GABORIAUD (Research director CEA, PhD)
Jean-Philippe KLEMAN (Research Engineer CEA, PhD)
Jean-Baptiste REISER (Staff scientist CNRS, PhD)
Véronique ROSSI (Associate professor UGA, PhD)
Pascale TACNET-DELORME (Research Engineer CNRS, PhD)
Nicole THIELENS (Research director INSERM PhD)
Catherine WICKER-PLANQUART (Staff scientist CNRS, PhD)
Guillaume FOUET (PhD student)
Samy DUFOUR (PhD student)
Fabien Dalonneau (Advanced Technician, CDD)

Students (2014-2018)

Christophe Moreau (PhD)
Rim Osman (PhD)
Catarina Tomé (PhD)
Sophie Colliard (M2 Immunology-Microbiology-Infectious Diseases, UGA)
Maëlle Plawecki (M2 Immunology-Microbiology-Infectious Diseases, UGA)
Julie Lopes (M2 Biochimie et Biologie Structurale UGA)
Guillaume Fouet (M2, Biochimie et Biologie Structurale, GRAL, UGA)
Bénédicte Ponsard (M1 UGA)
Samy Dufour (M1 UGA, M2 Immunology-Microbiology-Infectious Diseases, UGA)
Paul Ruiz (M1 Université du Maine)
Jessie Maillot (L3 UGA)
Aldrich Bertoncelli (L2 UGA)
Loriane Koelsch (L2 UGA)
Julie Bigay (L2 UGA)
Florine Borrel (L3 UGA)
Michel Kahi (L3 UGA)

Research themes of the IRPAS group

The group shares a common interest for the molecular recognition mechanisms involved in various aspects of the immune response to pathogens and altered self cells, and for the biological implications of these interactions in anti-microbial defence, maintenance of immune tolerance and evasion strategies of pathogens.
The soluble innate immune sensor proteins C1q, MBL and ficolins (defense collagens) play vital roles by sensing the extracellular environment and activating effector mechanisms involved in the clearance of pathogens and damaged host cells. These proteins have complementary recognition specificities and answer to danger signals through the activation of associated proteases which trigger the complement cascade. They also enhance phagocytosis by bridging the targets to phagocytic cell surface molecules.
Overall, these mechanisms ensure the delicate balance between immune defense and tolerance.

Research topics

- Defense collagens and immune response

- Molecules of innate immunity and pathologies

The research topics of our laboratory are studied with multidisciplinary approaches that allow to decipher the structure-function relationships of the protein of interest and their role at the cellular level.

Main methodological approaches

Key words

Apoptosis - Assembly - Complement - Innate immunity – Host/Pathogens interactions- Phagocytosis - Serine proteases - Receptors - Molecular recognition – Glycobiology – C1q – Altrered self

Publications

Publications of the IRPAS group
Until 2014
Since 2015

Theses

Theses of the IRPAS group

ISBG plateforms steered by IRPAS group members

Surface Plasmon Resonance platform (SPR) : Jean-Baptiste Reiser, Anne Chouquet - Cellular imaging (M4D) : Jean-Philippe Kleman