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Institut de Biologie StructuraleGrenoble / France

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Instruments for cellular sample preparation

Automated high-pressure freezer

Instrument : Leica EM-HPM100
Application : Cryo-fixation of biological sample under high pressure (2000 Bars).

Automated freeze substitution machine

Instrument : Leica EM-AFS2 + EM-FSP
Application : Freeze substitution process or Progressive Lowering of Temperature (PLT) for ambient or low-temperature embedding of sample, manually or automated with the FSP robot.

(Cryo-)ultra-microtome

Instrument : Leica EM-UC7 + EM-FC7
Application : Ultra-thin sectionning of embedded biological samples, at room temperature or in cryo-conditions.

Automated immuno-labeling machine

Instrument : Leica EM-IGL
Application : Automated staining or immuno-labelling steps on samples on grids (single particles or sections).