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Institut de Biologie StructuraleGrenoble / France

Publications since 2015

Our list of publications with peerReviewing, books and book sections since 2015 can be found here (data issued from HAL-IBS).

FDP Publications until 2014

Publications 2014

Barbet-Massin E, Schneider R, Felletti M, Jehle S, Communie G, Martinez N, Jensen MR, Ruigrok RWH, Emsley L, Lesage A, Blackledge M, Pintacuda P
Insights into the structure and dynamics of measles virus nucleocapsids by 1H-detected solid-state NMR
Biophys. J. 107, 941-946

Blanc M, Coetzer TL, Blackledge M, Haertlein M, Mitchell EP, Forsyth VT, Jensen MR.
Intrinsic disorder within the erythrocyte binding-like proteins from Plasmodium falciparum.
Biochim Biophys Acta 1844, 2306-2314

Communie G, Ruigrok RWH, Jensen MR and Blackledge M
Intrinsically disordered proteins implicated in paramyxoviral replication machinery. Curr. Opin. Virol. 5, 72–81.

Huang J-R, Warner LR, Sanchez C, Gabel F, Madl T, Mackereth CD, Sattler M and Blackledge M
Transient Electrostatic Interactions Dominate the Conformational Equilibrium Sampled by Multidomain Splicing Factor U2AF65: A Combined NMR and SAXS Study.
J. Am. Chem. Soc. 136, 7068–7076

Jensen MR and Blackledge M
Testing the validity of ensemble descriptions of intrinsically disordered proteins.
Proc. Natl. Acad. Sci. U. S. A. 111, E1557–1558.

Jensen MR, Zweckstetter M, Huang J-R and Blackledge M
Exploring Free-Energy Landscapes of Intrinsically Disordered Proteins at Atomic Resolution Using NMR Spectroscopy.
Chem. Rev. 114, 6632-6660

Krishnan N, Koveal D, Miller D H, Xue B, Akshinthala SD, Kragelj J, Jensen MR, Gauss C-M, Page R, Blackledge M, Muthuswamy SK, Peti W and Tonks NK
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.
Nat. Chem. Biol. 10, 558-566

Long D, Bouvignies G and Kay LE.
Measuring Hydrogen Exchange Rates in Invisible Protein Excited States.
Proc. Natl. Acad. Sci. (U.S.A.) 111, 8820-8825

Morin S, Linnet TE, Lescanne M, Schanda P, Thompson GS, Tollinger M, Teilum K, Gagné S, Marion D, Griesinger C, Blackledge M and d’ Auvergne, E J
relax: the analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data.
Bioinformatics 30, 2219-2220

Ozenne V, Noel JK, Heidarsson PO, Brander S, Poulsen FM, Jensen MR, Kragelund BB, Blackledge M and Danielsson, J.
Exploring the minimally frustrated energy landscape of unfolded ACBP.
J. Mol. Biol. 426, 722–734.

Parigi G, Rezaei-Ghaleh N, Giachetti A, Becker S, Fernandez C, Blackledge M, Griesinger C, Zweckstetter M, Luchinat C.
Long-range correlated dynamics in intrinsically disordered proteins.
J. Am. Chem. Soc. 136, 16201-16209.

Rasheed M, Richter C, Chisty LT, Kirkpatrick J, Blackledge M, Webb MR and Driscoll PC.
Ligand-dependent dynamics of the active-site lid in bacterial dimethylarginine dimethylaminohydrolase.
Biochemistry 53, 1092–1104.

Schwalbe M, Ozenne V, Bibow S, Jaremko M, Jaremko L, Gajda M, Jensen MR, Biernat J, Becker S, Mandelkow E, Zweckstetter M and Blackledge M.
Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering.
Structure 22, 238–249.

Sterckx YGJ, Volkov AN, Vranken WF, Kragelj J, Jensen MR, Buts L, Garcia-Pino A, Jové T, Van Melderen L, Blackledge M, van Nuland NAJ and Loris R
Small-Angle X-Ray Scattering- and Nuclear Magnetic Resonance-Derived Conformational Ensemble of the Highly Flexible Antitoxin PaaA2.
Structure 22, 854-865

Sukackaite R, Jensen MR, Mas PJ, Blackledge M, Buonomo SB and Hart DJ.
Structural and Biophysical Characterization of Murine Rif1 C Terminus Reveals High Specificity for DNA Cruciform Structures.
J. Biol. Chem. 289, 13903-13911

Varadi M, Kosol S, Lebrun P, Valentini E, Blackledge M, Dunker AK, Felli IC, Forman-Kay JD, Kriwacki RW, Pierattelli R, Sussman J, Svergun DI, Uversky VN, Vendruscolo M, Wishart D, Wright PE and Tompa P
pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins.
Nucleic Acids Res. 42, D326–335.

Publications 2013

Communie G, Crepin T, Maurin D, Jensen MR, Blackledge M and Ruigrok RWH
Structure of the tetramerization domain of measles virus phosphoprotein.
Journal of Virology (2013) 87(12): 7166-7169

Communie G, Habchi J, Yabukarski F, Blocquel D, Schneider R, Tarbouriech N, Papageorgiou N, Ruigrok RW, Jamin M, Ringkjobing Jensen M, Longhi S and Blackledge M
Atomic resolution description of the interaction between the nucleoprotein and phosphoprotein of Hendra virus.
PLoS Pathogens (2013) 9(9): e1003631

Guerry P, Mollica L and Blackledge M
Mapping protein conformational energy landscapes using NMR and molecular simulation.
Chemphyschem (2013) 14(13): 3046-3058

Guerry P, Salmon L, Mollica L, Ortega Roldan JL, Markwick P, van Nuland NA, McCammon JA and Blackledge M
Mapping the population of protein conformational energy sub-States from NMR dipolar couplings.
Angewandte Chemie International Edition (2013) 52(11): 3181-3185

Huang JR, Ozenne V, Jensen MR and Blackledge M
Direct prediction of NMR residual dipolar couplings from the primary sequence of unfolded proteins.
Angewandte Chemie International Edition (2013) 52(2): 687-690

Jensen MR, Ruigrok RW and Blackledge M
Describing intrinsically disordered proteins at atomic resolution by NMR.
Current Opinion in Structural Biology (2013) 23(3): 426-435

Iesmantavicius V, Jensen MR, Ozenne V, Blackledge M, Poulsen FM and Kjaergaard M
Modulation of the intrinsic helix propensity of an intrinsically disordered protein reveals long-range helix-helix interactions.
Journal of the American Chemical Society (2013) 135(27): 10155-10163

Kragelj J, Ozenne V, Blackledge M and Ringkjobing Jensen M
Conformational propensities of intrinsically disordered proteins from NMR chemical shifts.
Chemphyschem (2013) 14(13): 3034-3045

Mollica L, Baias M, Lewandowski JR, Wylie BJ, Sperling LJ, Rienstra CM, Emsley L and Blackledge M
Atomic-resolution structural dynamics in crystalline proteins from NMR and molecular simulation.
Journal of Physical Chemistry Letters (2013) 3(23): 3657-3662

Ortega Roldan JL, Casares S, Ringkjobing Jensen M, Cardenes N, Bravo J, Blackledge M, Azuaga AI and van Nuland NA
Distinct ubiquitin binding modes exhibited by SH3 domains: Molecular determinants and functional implications.
PLoS One (2013) 8(9): e73018

Pietrucci F, Mollica L and Blackledge M
Mapping the native conformational ensemble of proteins from a combination of simulations and experiments: New insight into the src-SH3 domain.
_ Journal of Physical Chemistry Letters (2013) 4(11): 1943-1948

Schneider R, Odronitz F, Hammesfahr B, Hellkamp M and Kollmar M
Peakr: simulating solid-state NMR spectra of proteins.
Bioinformatics (2013) 29(9): 1134-1140

Schwalbe M, Biernat J, Bibow S, Ozenne V, Jensen MR, Kadavath H, Blackledge M, Mandelkow E and Zweckstetter M
Phosphorylation of human tau protein by microtubule affinity-regulating kinase 2.
_ Biochemistry (2013) 52(50): 9068-9079

Publications 2012

Huang JR, Gabel F, Jensen MR, Grzesiek S and Blackledge M
Sequence-specific mapping of the interaction between urea and unfolded ubiquitin from ensemble analysis of NMR and small angle scattering data.
Journal of the American Chemical Society (2012) 134(9): 4429-4436

Huang JR, Gentner M, Vajpai N, Grzesiek S and Blackledge M
Residual dipolar couplings measured in unfolded proteins are sensitive to amino-acid specific geometries as well as local conformational sampling.
Biochemical Society Transactions (2012) 40(5): 989-994

Leyrat C, Schneider R, Ribeiro JEA, Yabukarski F, Yao M, Gerard FC, Jensen MR, Ruigrok RW, Blackledge M and Jamin M
Ensemble structure of the modular and flexible full-length vesicular stomatitis virus phosphoprotein.
Journal of Molecular Biology (2012) 423(2): 182-197

Mollica L, Baias M, Lewandowski JR, Wylie BJ, Sperling LJ, Rienstra CM, Emsley L and Blackledge M
Atomic-resolution structural dynamics in crystalline proteins from NMR and molecular simulation.
Journal of Physical Chemistry Letters (2012) 3(23): 3657-3662

Ozenne V, Bauer F, Salmon L, Huang JR, Jensen MR, Segard S, Bernado P, Charavay C and Blackledge M
Flexible-meccano: a tool for the generation of explicit ensemble descriptions of intrinsically disordered proteins and their associated experimental observables.
Bioinformatics (2012) 28(11): 1463-1470

Ozenne V, Schneider R, Yao M, Huang JR, Salmon L, Zweckstetter M, Jensen MR and Blackledge M
Mapping the potential energy landscape of intrinsically disordered proteins at amino acid resolution.
Journal of the American Chemical Society (2012) 134(36): 15138-15148

Rezaei-Ghaleh N, Blackledge M and Zweckstetter M
Intrinsically disordered proteins: From sequence and conformational properties toward drug discovery.
Chembiochem (2012) 13(7): 930-950

Salmon L, Jensen MR, Bernado P and Blackledge M
Measurement and analysis of NMR residual dipolar couplings for the study of intrinsically disordered proteins.
Methods in Molecular Biology (2012) 895: 115-125

Salmon L, Pierce L, Grimm A, Ortega Roldan JL, Mollica L, Jensen MR, van Nuland N, Markwick PR, McCammon JA and Blackledge M
Multi-timescale conformational dynamics of the SH3 domain of CD2-associated protein using NMR spectroscopy and accelerated molecular dynamics.
Angewandte Chemie International Edition (2012) 51(25): 6103-6106

Schneider R, Huang JR, Yao M, Communie G, Ozenne V, Mollica L, Salmon L, Ringkjobing Jensen M and Blackledge M
Towards a robust description of intrinsic protein disorder using nuclear magnetic resonance spectroscopy.
Molecular Biosystems (2012) 8 (1): 58-68

Silvers R, Sziegat F, Tachibana H, Segawa S, Whittaker S, Gunther UL, Gabel F, Huang JR, Blackledge M, Wirmer-Bartoschek J and Schwalbe H
Modulation of structure and dynamics by disulfide bond formation in unfolded states.
Journal of the American Chemical Society (2012) 134(15): 6846-6854

Sziegat F, Silvers R, Hahnke M, Jensen MR, Blackledge M, Wirmer-Bartoschek J and Schwalbe H
Disentangling the coil: Modulation of conformational and dynamic properties by site-directed mutation in the non-native state of hen egg white lysozyme.
Biochemistry (2012) 51(16): 3361-3372

Zachariae U, Schneider R, Briones R, Gattin Z, Demers JP, Giller K, Maier E, Zweckstetter M, Griesinger C, Becker S, Benz R, de Groot BL and Lange A
beta-barrel mobility underlies closure of the voltage-dependent anion channel.
Structure (2012) 20(9): 1540-1549

Publications 2011

Bibow S, Ozenne V, Biernat J, Blackledge M, Mandelkow E and Zweckstetter M
Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau.
Journal of the American Chemical Society (2011) 133 (40): 15842-15845

Dupeux F, Santiago J, Betz K, Twycross J, Park SY, Rodriguez L, Gonzalez-Guzman M, Jensen MR, Krasnogor N, Blackledge M, Holdsworth M, Cutler SR, Rodriguez PL and Márquez JA
A thermodynamic switch modulates abscisic acid receptor sensitivity.
EMBO Journal (2011) 30 (20): 4174-4184

Habchi J, Blangy S, Mamelli L, Ringkjobing Jensen M, Blackledge M, Darbon H, Oglesbee M, Shu Y and Longhi S
Characterization of the interactions between the nucleoprotein and the phosphoprotein of henipaviruses.
Journal of Biological Chemistry (2011) 286 (15): 13583-13602

Jensen MR, Communie G, Ribeiro EA, Jr., Martinez N, Desfosses A, Salmon L, Mollica L, Gabel F, Jamin M, Longhi S, Ruigrok RW and Blackledge M
Intrinsic disorder in measles virus nucleocapsids.
Proceedings of the National Academy of Sciences (2011) 108 (24): 9839-9844

Jensen MR, Ortega-Roldan JL, Salmon L, van Nuland N and Blackledge M
Characterizing weak protein-protein complexes by NMR residual dipolar couplings.
European Biophysics Journal (2011) 40 (12): 1371-1381

Lewandowski JR, Sass HJ, Grzesiek S, Blackledge M and Emsley L
Site-specific measurement of slow motions in proteins.
Journal of the American Chemical Society (2011) 133 (42): 16762-16765

Leyrat C, Ringkjobing Jensen M, Ribeiro Jr. EA, Gerard F, Ruigrok RW, Blackledge M and Jamin M
The N(0)-binding region of the vesicular stomatitis virus phosphoprotein is globally disordered but contains transient alpha-helices.
Protein Science (2011) 20 (3): 542-556

Leyrat C, Yabukarski F, Tarbouriech N, Ribeiro Jr EA, Jensen MR, Blackledge M, Ruigrok RWH and Jamin M
Structure of the vesicular stomatitis virus n0-p complex.
PLoS Pathogens (2011) 7 (9): e1002248

Roldan JL, Blackledge M, van Nuland NA and Azuaga AI
Solution structure, dynamics and thermodynamics of the three SH3 domains of CD2AP.
Journal of Biomolecular NMR (2011) 50 (2): 103-117

Salmon L, Bouvignies G, Markwick P and Blackledge M
Nuclear magnetic resonance provides a quantitative description of protein conformational flexibility on physiologically important time scales.
Biochemistry (2011) 50 (14): 2735-2747

Salmon L, Ortega Roldan JL, Lescop E, Licinio A, van Nuland N, Jensen MR and Blackledge M
Structure, dynamics, and kinetics of weak protein-protein complexes from NMR spin relaxation measurements of titrated solutions.
Angewandte Chemie International Edition (2011) 50 (16): 3755-3759

Tosi T, Nickerson NN, Mollica L, Jensen MR, Blackledge M, Baron B, England P, Pugsley AP and Dessen A
Pilotin-secretin recognition in the type II secretion system of Klebsiella oxytoca.
Molecular Microbiology (2011) 82 (6): 1422-1432

Publications 2010

Bernado P and Blackledge M
Structural biology: Proteins in dynamic equilibrium.
Nature (2010) 468(7327): 1046-1048

Blackledge M
Mapping the conformational mobility of multidomain proteins.
Biophysical Journal (2010) 98(10): 2043-2044

Gely S, Lowry DF, Bernard C, Jensen MR, Blackledge M, Costanzo S, Bourhis JM, Darbon H, Daughdrill G and Longhi S
Solution structure of the C-terminal X domain of the measles virus phosphoprotein and interaction with the intrinsically disordered C-terminal domain of the nucleoprotein.
Journal of Molecular Recognition (2010) 23(5): 435-447

Jensen MR, Bernado P, Houben K, Blanchard L, Marion D, Ruigrok RW and Blackledge M
Structural disorder within sendai virus nucleoprotein and phosphoprotein: Insight into the structural basis of molecular recognition.
Protein and Peptide Letters (2010) 17(8): 952-960

Jensen MR, Salmon L, Nodet G and Blackledge M
Defining conformational ensembles of intrinsically disordered and partially folded proteins directly from chemical shifts.
Journal of the American Chemical Society (2010) 132(4): 1270-1272

Lewandowski JR, Sein J, Blackledge M and Emsley L
Anisotropic collective motion contributes to nuclear spin relaxation in crystalline proteins.
Journal of the American Chemical Society (2010) 132(4): 1246-1248

Lewandowski JR, Sein J, Sass HJ, Grzesiek S, Blackledge M and Emsley L
Measurement of site-specific (13)C spin-lattice relaxation in a crystalline protein.
Journal of the American Chemical Society (2010) 132(24): 8252-8254

Markwick PR, Cervantes CF, Abel BL, Komives EA, Blackledge M and McCammon JA
Enhanced conformational space sampling improves the prediction of chemical shifts in proteins.
_ Journal of the American Chemical Society (2010) 132(4): 1220-1221

Salmon L, Nodet G, Ozenne V, Yin G, Jensen MR, Zweckstetter M and Blackledge M
NMR characterization of long-range order in intrinsically disordered proteins.
Journal of the American Chemical Society (2010) 132(24): 8407-8418

Vajpai N, Gentner M, Huang JR, Blackledge M and Grzesiek S
Side-chain chi(1) conformations in urea-denatured ubiquitin and protein G from (3)J coupling constants and residual dipolar couplings.
Journal of the American Chemical Society (2010) 132(9): 3196-3203

Publications 2009

Bernadó P and Blackledge M
A self-consistent description of the conformational behavior of chemically denatured proteins from NMR and small angle scattering.
Biophysical Journal (2009) 97(10): 2839-2845

Cho MK, Nodet G, Kim HY, Jensen MR, Bernado P, Fernandez CO, Becker S, Blackledge M and Zweckstetter M
Structural characterization of alpha-synuclein in an aggregation prone state.
Protein Science (2009) 18(9): 1840-1846

Estrada J, Bernado P, Blackledge M and Sancho J
ProtSA: a web application for calculating sequence specific protein solvent accessibilities in the unfolded ensemble.
BMC Bioinformatics (2009) 10: 104

Fischer D, Mukrasch MD, Biernat J, Bibow S, Blackledge M, Griesinger C, Mandelkow E and Zweckstetter M
Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules.
Biochemistry (2009) 48(42): 10047-10055

Gabel F, Jensen MR, Zaccai G and Blackledge M
Quantitative modelfree analysis of urea binding to unfolded ubiquitin using a combination of small angle X-ray and neutron scattering.
Journal of the American Chemical Society (2009) 131(25): 8769-8771

Lewandowski JR, Sein J, Blackledge M and Emsley L
Anisotropic Collective Motion Contributes to Nuclear Spin Relaxation in Crystalline Proteins.
Journal of the American Chemical Society (2009) 132(4): 1246-1248

Markwick PR, Bouvignies G, Salmon L, McCammon JA, Nilges M and Blackledge M
Toward a unified representation of protein structural dynamics in solution.
Journal of the American Chemical Society (2009) 131(46): 16968-16975

Markwick PR, Showalter SA, Bouvignies G, Bruschweiler R and Blackledge M
Structural dynamics of protein backbone phi angles: extended molecular dynamics simulations versus experimental (3) J scalar couplings.
Journal of Biomolecular NMR (2009) 45(1-2): 17-21

Nodet G, Salmon L, Ozenne V, Meier S, Jensen MR and Blackledge M
Quantitative description of backbone conformational sampling of unfolded proteins at amino acid resolution from NMR residual dipolar couplings.
Journal of the American Chemical Society (2009) 131(49): 17908-17918

Ortega-Roldan JL, Jensen MR, Brutscher B, Azuaga AI, Blackledge M and van Nuland NA
Accurate characterization of weak macromolecular interactions by titration of NMR residual dipolar couplings: application to the CD2AP SH3-C:ubiquitin complex.
Nucleic Acids Research (2009) 37(9): e70

Ringkjøbing-Jensen M, Markwick PRL, Meier S, Griesinger C, Zweckstetter M, Grzesiek S, Bernadó P and Blackledge M
Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings.
Structure (2009) 17(9): 1169-1185

Salmon L, Bouvignies G, Markwick P, Lakomek N, Showalter S, Li DW, Walter K, Griesinger C, Bruschweiler R and Blackledge M
Protein conformational flexibility from structure-free analysis of NMR dipolar couplings: quantitative and absolute determination of backbone motion in ubiquitin.
Angewandte Chemie International Edition England (2009) 48(23): 4154-4157

Publications 2008

Bouvignies G, Markwick PR and Blackledge M
Characterization of protein dynamics from residual dipolar couplings using the three dimensional Gaussian axial fluctuation model. restaurants.
Proteins (2008) 71(1): 353-363

Hus JC, Salmon L, Bouvignies G, Lotze J, Blackledge M and Bruschweiler R
16-fold degeneracy of peptide plane orientations from residual dipolar couplings: Analytical treatment and implications for protein structure determination.
Journal of the American Chemical Society (2008) 130(47): 15927-15937

Jensen MR and Blackledge M
On the origin of NMR dipolar waves in transient helical elements of partially folded proteins.
Journal of the American Chemical Society (2008) 130(34): 11266-11267

Jensen MR, Houben K, Lescop E, Blanchard L, Ruigrok RW and Blackledge M
Quantitative conformational analysis of partially folded proteins from residual dipolar couplings: application to the molecular recognition element of Sendai virus nucleoprotein.
Journal of the American Chemical Society (2008) 130(25): 8055-8061

Meier S, Blackledge M and Grzesiek S
Conformational distributions of unfolded polypeptides from novel NMR techniques.
Journal of Chemical Physics (2008) 128(5): 052204

Mylonas E, Hascher A, Bernado P, Blackledge M, Mandelkow E and Svergun DI
Domain conformation of tau protein studied by solution small-angle X-ray scattering.
Biochemistry (2008) 47(39): 10345-10353

Ribeiro EA, Favier A, Gerard FCA, Leyrat C, Brutscher B, Blondel D, Ruigrok RW, Blackledge M and Jamin M
Solution structure of the C-terminal nucleoprotein-RNA binding domain of the vesicular stomatitis virus phosphoprotein.
Journal of Molecular Biology (2008) 382(2): 525-538

Wells M, Tidow H, Rutherford TJ, Markwick P, Jensen MR, Mylonas E, Svergun DI, Blackledge M and Fersht AR
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.
Proceedings of the National Academy of Sciences U S A (2008) 105(15): 5762-5767

Publications 2007

Bernado P, Mylonas E, Petoukhov MV, Blackledge M and Svergun DI
Structural characterization of flexible proteins using small-angle X-ray scattering.
Journal of the American Chemical Society (2007) 129(17): 5656-5664

Boudet J, Duval V, Van Melckebeke H, Blackledge M, Amoroso A, Joris B and Simorre JP
Conformational and thermodynamic changes of the repressor/DNA operator complex upon monomerization shed new light on regulation mechanisms of bacterial resistance against beta-lactam antibiotics.
Nucleic Acids Research (2007) 35(13): 4384-4395

Bouvignies G, Markwick PR and Blackledge M
Simultaneous definition of high resolution protein structure and backbone conformational dynamics using NMR residual dipolar couplings.
Chemphyschem (2007) 8(13): 1901-1909

Cho MK, Kim HY, Bernado P, Fernandez CO, Blackledge M and Zweckstetter M
Amino acid bulkiness defines the local conformations and dynamics of natively unfolded alpha-synuclein and tau.
Journal of the American Chemical Society (2007) 129(11): 3032-3033

Giraud N, Blackledge M, Bockmann A and Emsley L
The influence of nitrogen-15 proton-driven spin diffusion on the measurement of nitrogen-15 longitudinal relaxation times.
Journal of Magnetic Resonance (2007) 184(1): 51-61

Houben K, Blanchard L, Blackledge M and Marion D
Intrinsic dynamics of the partly unstructured PX domain from the Sendai virus RNA polymerase co-factor P.
Biophysical Journal (2007) 93(8): 2830-2844

Markwick PR, Bouvignies G and Blackledge M
Exploring multiple timescale motions in protein GB3 using accelerated molecular dynamics and NMR spectroscopy.
Journal of the American Chemical Society (2007) 129(15): 4724-4730

Meier S, Grzesiek S and Blackledge M
Mapping the conformational landscape of urea-denatured ubiquitin using residual dipolar couplings.
Journal of the American Chemical Society (2007) 129(31): 9799-9807

Meier S, Strohmeier M, Blackledge M and Grzesiek S
Direct observation of dipolar couplings and hydrogen bonds across a beta-hairpin in 8 M urea.
Journal of the American Chemical Society (2007) 129(4): 754-755

Mukrasch MD, Markwick P, Biernat J, Bergen M, Bernado P, Griesinger C, Mandelkow E, Zweckstetter M and Blackledge M
Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation.
Journal of the American Chemical Society (2007) 129(16): 5235-5243

Sein J, Giraud N, Blackledge M and Emsley L
The role of (15)N CSA and CSA/dipole cross-correlation in (15)N relaxation in solid proteins.
Journal of Magnetic Resonance (2007) 168(1): 26-33

Publications 2006

Bernado P, Blackledge M and Sancho J
Sequence-specific solvent accessibilities of protein residues in unfolded protein ensembles.
Biophysical Journal (2006) 91(12): 4536-4543

Bouvignies G, Markwick P, Bruschweiler R and Blackledge M
Simultaneous determination of protein backbone structure and dynamics from residual dipolar couplings.
Journal of the American Chemical Society (2006) 128(47): 15100-15101

Bouvignies G, Meier S, Grzesiek S and Blackledge M
Ultrahigh-resolution backbone structure of perdeuterated protein GB1 using residual dipolar couplings from two alignment media.
Angewandte Chemie International Edition (2006) 45(48): 8166-8169

Dames SA, Aregger R, Vajpai N, Bernado P, Blackledge M and Grzesiek S
Residual dipolar couplings in short peptides reveal systematic conformational preferences of individual amino acids.
Journal of the American Chemical Society (2006) 128(41): 13508-13514

Giraud N, Sein J, Pintacuda G, Bockmann A, Lesage A, Blackledge M and Emsley L
Observation of heteronuclear overhauser effects confirms the N-15-H-1 dipolar relaxation mechanism in a crystalline protein.
Journal of the American Chemical Society (2006) 128(38): 12398-12399

Reinscheid UM, Farjon J, Radzom M, Haberz P, Zeeck A, Blackledge M and Griesinger C
Effect of the solvent on the conformation of a depsipeptide: NMR-derived solution structure of hormaomycin in DMSO from residual dipolar couplings in a novel DMSO-compatible alignment medium.
Chembiochem (2006) 7(2): 287-296

Skora L, Cho MK, Kim HY, Fernandez C, Blackledge M and Zweckstetter M
Charge-induced molecular alignment of intrinsically disordered proteins.
Angewandte Chemie International Edition (2006) 45: 7012-7015

Publications 2005

Bernado P, Bertoncini CW, Griesinger C, Zweckstetter M and Blackledge M
Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings.
Journal of the American Chemical Society (2005) 127(51): 17968-17969

Bernado P, Blanchard L, Timmins P, Marion D, Ruigrok RW and Blackledge M
A structural model for unfolded proteins from residual dipolar couplings and small-angle x-ray scattering.
Proceedings of the National Academy of Sciences U S A (2005) 102(47): 17002-17007

Blackledge M
Recent progress in the study of biomolecular structure and dynamics in solution from residual dipolar couplings.
Progress in Nuclear Magnetic Resonance Spectroscopy (2005) 46(1): 23-61

Bouvignies G, Bernado P and Blackledge M
Protein backbone dynamics from N-HN dipolar couplings in partially aligned systems: a comparison of motional models in the presence of structural noise.
Journal of Magnetic Resonance (2005) 173(2): 328-338

Bouvignies G, Bernado P, Meier S, Cho K, Grzesiek S, Bruschweiler R and Blackledge M
Identification of slow correlated motions in proteins using residual dipolar and hydrogen-bond scalar couplings.
Proceedings of the National Academy of Sciences U S A (2005) 102(39): 13885-13890

Giraud N, Blackledge M, Goldman M, Bockmann A, Lesage A, Penin F and Emsley L
Quantitative analysis of backbone dynamics in a crystalline protein from nitrogen-15 spin-lattice relaxation.
Journal of the American Chemical Society (2005) 127(51): 18190-18201

Sibille N, Blackledge M, Brutscher B, Coves J and Bersch B
Solution structure of the sulfite reductase flavodoxin-like domain from Escherichia coli.
Biochemistry (2005) 44(25): 9086-9095.

Publications 2004

Bernado P and Blackledge M
Anisotropic small amplitude peptide plane dynamics in proteins from residual dipolar couplings.
Journal of the American Chemical Society (2004) 126(15): 4907-4920

Bernadó P and Blackledge M
Local dynamic amplitudes on the protein backbone from dipolar couplings: toward the elucidation of slower motions in biomolecules.
Journal of the American Chemical Society (2004) 126(25): 7760 - 1761

Blanchard L, Tarbouriech N, Blackledge M, Timmins P, Burmeister WP, Ruigrok RWH and Marion D
Structure and dynamics of the nucleocapsid-binding domain of the Sendai virus phosphoprotein in solution.
Virology (2004) 319(2): 201-211

Bouvignies G, Bernado P and Blackledge M
Modélisation de la dynamique de la chaîne peptidique des protéines en solution par RMN à travers les couplages dipolaires residuels.
Journal de Physique IV (2005) 130: 229-244

Giraud N, Böckmann A, Lesage A, Penin F, Blackledge M and Emsley L
Site-specific backbone dynamics from a crystalline protein by solid-state NMR spectroscopy.
Journal of the American Chemical Society (2004) 126(37): 11422 - 11423