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Scientists discover a new way to read the histone code by studying streamlined sperm
In the quest for speed, olympic swimmers shave themselves or squeeze into high-tech super-suits. In the body, sperm are the only cells that swim and, as speed is crucial to fertility, have developed their own ways to become exceptionally streamlined. Scientists at the Institut de Biologie Structurale (IBS), the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Institut Albert Bonniot in Grenoble, have been studying the secrets of speedy sperm. Their work, published in Nature, shows how a protein only found in developing sperm cells, Brdt, directs tight re-packaging of sperm DNA. [Presse release]
Cooperative binding of two acetylation marks on a histone tail by a single bromodomain. Morinière, J., Rousseaux, S., Steuerwald, U., Soler-López, M., Curtet, S., Vitte, A-L., Govin, J., Gaucher, J., Sadoul, K., Hart, D.J., Krijgsveld, J., Khochbin, S., Müller, C.W. & Petosa, C. Nature, 461(7264):664-8.