Institut de Biologie StructuraleGrenoble / France


05/01/2015 - Atomic model of a cell-wall cross-linking enzyme in complex with an intact bacterial peptidoglycan
Researchers from the NMR group shed light on the synthesis molecular machinery of a bacterial cell wall. This study was conducted by "solid-state NMR spectroscopy" on the enzyme L, D-transpeptidase, which participates in the synthesis of the bacterial wall. The results, published in JACS, are important for designing new antibiotic molecules against which bacteria would have no resistance mechanism.
Press release (in french only)

01/08/2014 - Pharmacology : serotonine receptor structure revealed

For the first time the X-ray structure of serotonin receptor was deciphered. The study, published online in Nature on August 03, 2014, paves the way for the design of new drugs against nausea, a main side effect of chemotherapy and anesthesia. It was conducted by IBS researchers in collaboration with researchers from the laboratory Architecture and Function of Biological Macromolecules, Swiss researchers and the participation of Théranyx..
Press Release