Institut de Biologie StructuraleGrenoble / France

2018

06/12/18 - The main target of HIV studied from every angle
By closely studying CCR5, one of the entry points of HIV into cells, researchers from Inserm, the Institut Pasteur, the University of Toulouse III - Paul Sabatier, the CNRS and IBS, demonstrate that its morphology determines the propensity of the virus to infect the body. This work supported by the ANRS and published in the Plos Pathogens journal is a new step towards understanding the role of CCR5 in HIV infection and as a target for blocking the entry of the virus into cells
Press information (in french only)


31/10/18 - New insights into 5-HT3, a serotonin receptor
This result, published in Nature, describes the activation cycle of the 5-HT3 receptor, belonging to the family of serotonin receptors. These receptors influence various biological and neurological processes such as anxiety, appetite, mood and nausea. 5-HT3 receptors are the main target of anti-emetic drugs widely used to alleviate the side effect of chemotherapies.
Scientists from the IBS, the Institut Pasteur, the University of Lorraine, the University of Copenhagen, Danemark, the University of Illinois, US, and the biotech company Theranyx, solved the structure of the 5-HT3 receptor in four different conformations. These four snapshots taken at different steps of the activation cycle of the receptor allow to describe its molecular mechanism. They also provide structural knowledge for pharmacology, revealing details of the serotonin and drug binding site, and may therefore help the development of more efficient anti-emetics. These findings, are published in Nature on October 31.
ESRF press release


22/08/18 - Revealing molecular mechanisms that prevent measles virus replication
IBS Researchers, in collaboration with the CIRI, discovered a novel interaction between two proteins from the measles virus. This ultra-weak interaction, involving only four amino acids situated in a very flexible and dynamic protein region, is essential for measles virus replication. This newly discovered interaction constitutes a new target to treat measles infection, but also infection by other viruses from the same family, that comprises highly dangerous human pathogens. These results are published in Science Advances, on August 22nd, 2018.
Press information