A Unified Description of Intrinsically Disordered Protein Dynamics under Physiological Conditions using NMR Spectroscopy
2019
Scientists estimate that one third of human proteins are intrinsically disordered proteins (IDPs), i.e. proteins without a stable three-dimensional structure. Very flexible, these biomolcules can adapt to several physiological partners and adopt a multitude of conformations. Their functioning remains poorly understood even though they play essential roles in all living organisms. Nuclear magnetic resonance (NMR) spectroscopy is ideally suited to the investigation of this behavior at atomic (…)