
Characterization of a key meiosis regulatory complex
Highlights
During meiosis, the formation of DNA double-strand breaks by the catalytic complex SPO11/TOPOVIBL and their repair through meiotic recombination are crucial mechanisms for the precise segregation of homologous chromosomes and the formation of gametes. However, the formation of these breaks can be dangerous and lead to undesirable chromosomal rearrangements if they are not introduced at the appropriate time and repaired correctly. Therefore, the activity of the SPO11-TOPOVIBL complex is (...)