EMBO Practical Course ’Structural characterisation of macromolecular complexes’
Date
From 27 May at 09:00 to 3 June at 17:30
Localisation
EPN Campus
Recent advances in cryo-electron microscopy/tomography (cryo-EM/ET), super-resolution microscopy, and deep-learning-based protein structure prediction, combined with increasingly sophisticated sample preparation methods, have transformed structural biology. Solving the field’s most complex challenges will require researchers who can strategically integrate these powerful tools. This course provides a comprehensive overview of modern structural biology methods, with emphasis on sample preparation, characterisation, and data integration.
Course participants (advanced PhD students and postdocs, currently working on challenging projects in structural biology that would benefit form hybrid approaches) will learn 3D structure determination of macromolecular assemblies at various resolution scales, and strategies to integrate data from X-ray crystallography, cryo-EM, SAXS, NMR, mass spectrometry, smFRET, and super-resolution microscopy.
Scientific organisers: M. Bowler (EMBL Grenoble), S. Bhogaraju (EMBL Grenoble), A. Casañal (Human Technopole, Italy), C. Petosa (IBS), M. Soler López (ESRF).