Identification and characterization of a monomer-dimer exchange process in the excited state of beta2 microglobulin by a combination of real-time NMR and CPMG relaxation-dispersion NMR. This conformational state has been previously shown in our team to be 7 times more prone to aggregation than the native state.
Publication: Rennella et al. J. Mol. Biol. 2013 425, 2722-2736, doi:10.1016/j.jmb.2013.04.028.
Collaborations: A.Corazza, G. Esposito (Univ. of Udine, Italy); V. Forge (iRTSV, CEA Grenoble, France)