Team leader: Jan Kadlec
The goal of our team is to understand molecular mechanisms underlying the activities of epigenetic regulatory complexes such as histone acetyltransferases and methyltransferases. We also investigate the mechanisms of RNA biogenesis and degradation. To obtain molecular insights into the functions of important chromatin and RNA regulatory complexes and their role in human disease, we use an interdisciplinary approach combining biochemical, biophysical and structural analyses (X-ray crystallography and cryo-electron microscopy) with cell biology and genetics.
Étienne Dubiez, Anne-Emmanuelle Foucher, Jean-Baptiste Izquierdo, Jan Kadlec, Hamida Laroussi