Archaea are prokaryotic microrganisms displaying close evolutionary links with the eukaryotic cells. The study of archaeal systems facilitates the understanding of the origins and mode of action of complex cellular processes. We have a long standing interest in stress response cellular machines responsible for proteome dynamic and maintenance. Our current research concerns archaeal peptidases, proteasomes, unfoldases and post-translational modification systems that underpin cellular fitness and environmental adaptation. This research provide original biological systems that are also studied in the context of the two other research themes of the group.