Research Activities

Our team is synergistically developing advanced in vivo and in vitro labeling methods together with optimized NMR spectroscopy to push forward the limit of application of NMR into Biology. We are integrating these innovative methods with other biophysics approaches in order to study folding, structure, dynamics, transient interactions, and mechanisms of essential cellular machineries and large chaperones. We have harnessed the power of methyl-specific labeling (e.g. Ala, Val, Ile, Leu, Met, Thr) and methyl-NMR (CH₃-NMR) to expand our investigation of proteins to assemblies of up to 1 MDa, and plan to expand beyond under our new ERC-funded project, XXL-NMR.