Group presentation

Group leader: Franck FIESCHI

Group composition:
 Membrane and Immunity Team (F. Fieschi).
 Structure and Stability of Integral Membrane Proteins and Phage Assemblies (C. Breyton).

Research themes:
 Neutrophilic NADPH oxidase complex.
 C-type lectin receptors of dendritic cells.
 Mechanism of phage infection.
 New surfactants for the in vitro study of membrane proteins.
 Structural study of membrane proteins related to virulence and pathogenicity.

Specialized techniques:
 Biochemistry of membrane and soluble proteins.
 Protein refolding.
 Automation in protein purification.
 Molecular interactions (SPR, BLI, ITC).
 Analytical ultracentrifugation.
 Size exclusion chromatography/light scattering.
 Small angle X-Rays and neutrons scattering.
 Cryo Electron Microscopy.

Available services:
 Clinical Diagnostic Centre CHU Grenoble Alpes:
Centre de Diagnostic de la Granulomatose Septique (CDiReC).

 ISBG platforms:
Analytical ultracentrifugation (platform AUC).
SECMALLS (platform PAOL).

 IBS instrument:
Multistep Protein Purification System (MP3).
Prometheus (NanoDSF).