Team Nuclear Replication Viruses

Chef d’équipe : Thibaut Crépin (DR2-CNRS)

The Negarnaviricota phylum (negative-sense, single-stranded, RNA viruses) includes many human pathogens (rabies, influenza, Lassa fever viruses, etc.). It is divided into two sub-branches, depending on whether the genome is made up of a single molecule or several. Most of these pathogens replicate in the cytoplasm. The team, founded by Rob Ruigrok, originally worked on all viruses and was a pioneer in the structural study of the partners involved in viral replication. Since then, the team has refocused on the few viruses that replicate in the nucleus of the cells, to gain structural insight into the molecular mechanisms of i) their proliferation in this particular environment and ii) the dynamics of the multiple interactions they establish. A representative of each sub-branch is so studied: influenza virus (segmented RNA virus) and Borna disease virus (non-segmented RNA virus).

Members

Permanents
• Allison Ballandras-Colas, CNRS research associate
• Thibaut Crépin, CNRS director of research
• Rob Ruigrok, UGA professor

Non-permanents
• Lily-Lorette Freslon, CNRS research engineer
• Alice Stelfox, CNRS PostDoc
• Marie Thirion, GRAL-UGA doctoral student