Team Crepin/Ruigrok

Responsible: Thibaut Crépin

Replication of negative-sense single-stranded RNA viruses

Negative strand RNA viruses (NSV) have their viral RNA complementary to their mRNA. The viral RNAs are bound to their nucleoprotein to form protein-RNA complexes that are specifically read by a viral RNA-dependent RNA polymerase (RdRp). NSV are classified depending on their genome organization. There are viruses with one long RNA molecule made by several genes, the non-segmented NSV, and viruses with several RNA molecules, the segmented NSV (4). Our team work on influenza virus, a segmented virus, and also on measles virus, a non-segmented virus.