IBS Researchers, in collaboration with the CIRI, discovered a novel interaction between two proteins from the measles virus. This ultra-weak interaction, involving only four amino acids situated in a very flexible and dynamic protein region, is essential for measles virus replication. This newly discovered interaction constitutes a new target to treat measles infection, but also infection by other viruses from the same family, that comprises highly dangerous human pathogens. These results are published in Science Advances, on August 22nd, 2018.
An ultra-weak interaction in the intrinsically disordered replication machinery is essential for Measles virus function. S. Milles, M. R. Jensen, C. Lazert, S. Guseva, S. Ivashchenko, G. Communie, D. Maurin, D. Gerlier, R. W. H. Ruigrok, M. Blackledge. Sci. Adv. 4, eaat7778