To fight the virus that causes influenza, one of the avenues being explored by scientists is the development of drugs capable of destabilising its genome, made up of eight RNA molecules.
A first article published in 2023 proposed an initial model for the encapsidation of the influenza virus genome.
In a new publication published in the journal Nucleic Acids Research on 16 December 2024, the same scientists have now obtained a high-resolution structure of the Influenza nucleoprotein in an antiparallel helix, that now details precisely all the protein-protein and protein-RNA interactions within the nucleocapsid.
Influenza A virus antiparallel helical nucleocapsid-like pseudo-atomic structure. Florian Chenavier, Eleftherios Zarkadas, Lily-Lorette Freslon, Alice J. Stelfox, Guy Schoehn, Rob W.H. Ruigrok, Allison Ballandras-Colas, Thibaut Crépin. Nucleic Acids Research 2024 Dec 14:gkae1211. doi : 10.1093/nar/gkae1211.
Contact : Thibaut Crepin (IBS/Viral Replication Machines Group)