Nanodiamonds (NDs) have many potential biomedical applications, such as cancer therapy, deep brain stimulation, and dentistry. In collaboration with the Service de Chimie Bioorganique et de Marquage (SCBM, CEA, Université Paris-Saclay), IBS researchers have shown that, even though C1q does not trigger the immune complement system cascade, its interaction modifies phagocytosis and cytokine response to NDs and may interfere with the multiple physiological and pathological processes that involve C1q.
Recognition protein C1q of innate immunity agglutinates nanodiamonds without activating complement. Belime A, Thielens NM, Gravel E, Frachet P, Ancelet S, Tacnet P, Caneiro C, Chuprin J, Gaboriaud C, Schoehn G, Doris E, Ling WL. Nanomedicine-Nanotechnology, Biology and Medicine ; doi : 10.1016/j.nano.2018.09.009