An IBS state-of-the-art cryo-microscope inaugurated on Nov. 08, 2024

This Titan Krios transmission electron microscope, funded by the french program ’Investissement d’Avenir 3’, is specially designed for cryo-electron microscopy (cryoEM) in biology. Hosted by ESRF, it is made available to the French and European scientific community and operated by the IBS and the ISBG. Details below.

This state-of-the-art instrument is part of a network of three microscopes located in France, at the IGBMC in Illkirch-Graffenstaden, the Synchrotron Soleil in Saint-Aubin, and the Institut de Biologie Structurale/@ESRF in Grenoble.

This 300 kV cryo-electron microscope (Thermo Scientific Titan Krios G4), is equipped with a cold FEG, a Selectris X energy filter, a Falcon 4i direct electron detector and a Volta Phase Plate.

Thanks to its exceptional performance, the Titan Krios G4, represents a major technological advance for structural biology research. It will enable the structures of biological macromolecular complexes to be resolved at the atomic scale, opening up new prospects for the development of medical therapies and the understanding of fundamental biological mechanisms.

This microscope was inaugurated on Friday November 8, 2024, by representatives of CNRS, ESRF, Université Grenoble Alpes (UGA) and CEA, as well as representatives of local authorities.