Fluorescent proteins are widely used in biological research to make all kinds of cell types or structures visible. A research team from the University of Amsterdam has developed a new bright red fluorescent protein, mScarlet3, which combines maximum brightness with fast and complete folding. They sent their creation to the Institut de Biologie Structurale in Grenoble, where structural biologist Antoine Royant mapped the molecular structure of the protein, using the European Synchrotron ESRF. Altogether, they publish the properties and the DNA code for this protein in the leading magazine Nature Methods. It is expected to become the new red FP standard in fluorescence microscopy (details).
mScarlet3 : a brilliant and fast maturing red fluorescent protein. Theodorus W.J. Gadella Jr*, Laura van Weeren, Jente Stouthamer, Mark A. Hink, Anouk H.G. Wolters, Ben N.G. Giepmans, Sylvain Aumonier, Jérôme Dupuy, Antoine Royant. Nature Methods, https://doi.org/10.1038/s41592-023-01809-y
Contact IBS : Antoine Royant (IBS/Synchrotron Group)