Presentation

Group leader : Bernhard Brutscher

Currently the group is composed of 2 research teams headed by JP. Simorre and B. Brutscher. Both teams develop and exploit modern NMR methodologies to answer various biological and biophysical questions. The current main research topics focus on (i) the biogenesis of the bacterial cell wall and the development of new antibiotic strategies ; and (ii) the mechanistic understanding of light-induced transformations of fluorescent and other light-sensing proteins. These topics are addressed primarily by NMR methods, complemented by other biophysical and biochemical techniques, in particular SAXS, electron and light microscopy and X-ray crystallography, as well as by in vivo/functional experiments. To carry out this work, we have established a network of internationally renowned collaborators in these fields. The group has also a strong activity in the development of innovative NMR methods, both in solution and solid-state NMR, and has made significant efforts to make these tools available to the scientific community.