Pierre Caron
CNRS researcher, CRCN
phone : +33 (0)4 57 42 85 66
email : pierre.caron[at]ibs.fr
My research focuses on the study of DNA repair mechanisms in response to genotoxic agents and anticancer therapeutic molecules. During my PhD and post-doctoral works, I used innovative cell models combined with a wide range of techniques to induce DNA damage. As a result, I was able to decipher key mechanisms involved in chromatin maintenance and in the regulation of DNA repair events in the context of chromatin.
In 2024, I joined the laboratory of Joanna Timmins at the Institute of Structural Biology (IBS) to continue exploring DNA repair within the nuclear space. Thanks to the laboratory’s expertise and the unique environment offered by the IBS and the IRIG campus, I am developing and using advanced proteomics and microscopy approaches to characterize and map DNA repair mechanisms in different parts of the genome in response to various genotoxic agents and anticancer compounds. This work will provide a better understanding of the mechanisms that regulate the stability of our genome. Finally, we hope to identify new anti-cancer therapeutic targets and develop personalized medicine by helping to predict patients’ response to therapies based on their genetic characteristics.