Bacterial sporulation is a morphological differentiation process leading to the development of a spore that is resistant to extreme environments. Proper development of the spore requires the assembly of a multiprotein complex called the SpoIIIA-SpoIIQ complex or "A-Q complex". This complex displays similarities to endotoxin secretion systems and has been hypothesized to serve as a channel for molecular transport between the mother cell and the developing spore. We are studying the structure of the A-Q complex from Bacillus subtilis and Clostridia using biophysics, crystallography and cryo-EM.
Collaborations : G. Schoehn (IBS) ; D. Rudner (Harvard, Boston) ; C. Rodrigues (Univ. of Technology, Sydney, Australia).