Group leader : Franck FIESCHI
Group composition :
– Membrane and Immunity Team (F. Fieschi).
– Structure and Stability of Integral Membrane Proteins and Phage Assemblies (C. Breyton).
Research themes :
– Neutrophilic NADPH oxidase complex.
– C-type lectin receptors of dendritic cells.
– Mechanism of phage infection.
– New surfactants for the in vitro study of membrane proteins.
– Structural study of membrane proteins related to virulence and pathogenicity.
Specialized techniques :
– Biochemistry of membrane and soluble proteins.
– Protein refolding.
– Automation in protein purification.
– Molecular interactions (SPR, BLI, ITC).
– Fluorescence.
– Analytical ultracentrifugation.
– Size exclusion chromatography/light scattering.
– Small angle X-Rays and neutrons scattering.
– Crystallography.
– Cryo Electron Microscopy.
– NanoDSF.
Available services :
– Clinical Diagnostic Centre CHU Grenoble Alpes :
Centre de Diagnostic de la Granulomatose Septique (CDiReC).
– ISBG platforms :
Analytical ultracentrifugation (platform AUC).
SECMALLS (platform PAOL).
– IBS instrument :
Multistep Protein Purification System (MP3).
Prometheus (NanoDSF).