Institut de Biologie StructuraleGrenoble / France

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Liste des Publications

Hograindleur MA, Effantin G, Fenel D, Mas C, Lieber A, Schoehn G, Fender P and Vassal-Stermann E. Binding Mechanism Elucidation of the Acute Respiratory Disease Causing Agent Adenovirus of Serotype 7 to Desmoglein-2. Viruses. 2020 Sep 25 ;12(10):E1075. doi : 10.3390/v12101075. PMID : 32992715.

Besson S, Vragniau C, Vassal-Stermann E , Dagher MC and Fender P. The Adenovirus Dodecahedron : Beyond the Platonic Story. Viruses 2020, 12(7), 718 ;

Vassal-Stermann E, Effantin G, Zubieta C, Burmeister W, Iseni F, Wang H, Lieber A, Schoehn G, Fender P. CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement. Nat Commun. 2019 Mar 12 ;10(1):1181. doi : 10.1038/s41467-019-09220-y.

Vragniau C, Bufton JC, Garzoni F, Stermann E, Rabi F, Terrat C, Guidetti M, Josserand V, Williams M, Woods CJ, Viedma G, Bates P, Verrier B, Chaperot L, Schaffitzel C, Berger I, Fender P.
Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display.
Sci Adv. 2019 Sep 25 ;5(9):eaaw2853. doi : 10.1126/sciadv.aaw2853.

Pitner R, Kim J, Davis-Bergthold J, Turner C, Vassal-Stermann E, Wang H, Adams J, Carter L, Ahlgren JA, Fender P, Lieber A, Carter D, Gray SA.
Structure-based Design of JOC-x, a Conjugatable Tumor Tight Junction Opener to Enhance Cancer Therapy.
Sci Rep. 2019 Apr 16 ;9(1):6169. doi : 10.1038/s41598-019-42229-3.

Furnon W, Fender P, Confort MP, Desloire S, Nangola S, Kitidee K, Leroux C, Ratinier M, Arnaud F, Lecollinet S, Boulanger P, Hong SS.
Remodeling of the Actin Network Associated with the Non-Structural Protein 1 (NS1) of West Nile Virus and Formation of NS1-Containing Tunneling Nanotubes.
Viruses. 2019 Sep 27 ;11(10). pii : E901. doi : 10.3390/v11100901.

Vassal-Stermann E, Mottet M, Ducournau C, Iseni F, Vragniau C, Wang H, Zubieta C, Lieber A, Fender P. Mapping of Adenovirus of serotype 3 fibre interaction to desmoglein 2 revealed a novel ’non-classical’ mechanism of viral receptor engagement. Sci Rep. 2018 30 ;8(1):8381.

Vragniau C, Hübner JM, Beidler P, Gil S, Saydaminova K, Lu ZZ, Yumul R, Wang H, Richter M, Sova P, Drescher C, Fender P, Lieber A. Studies on the Interaction of Tumor-Derived HD5 Alpha Defensins with Adenoviruses and Implications for Oncolytic Adenovirus Therapy. J Virol. 2017 ; 91(6). e02030-16.

Fallecker C, Caporossi A, Rechoum Y, Garzoni F, Larrat S, François O, Fender P, Morand P, Berger I, Petit MA, Drouet E. New insights into HCV replication in original cells from Aedes mosquitoes. Virol J. 2017 ; 14(1):161.

Sumarheni S, Gallet B, Fender P. The Use of Adenovirus Dodecahedron in the Delivery of an Enzymatic Activity in the Cell. Biotechnology research international, 2016, 2016, pp.5030589.

Wang H, Ducournau C, Saydaminova K, Richter M, Yumul R, Ho M, Carter D, Zubieta C, Fender P, Lieber A. Intracellular signaling and desmoglein 2 shedding triggered by human adenoviruses Ad3, Ad14, and Ad14P1. J Virol. 2015 ; 89(21) : 10841-59

Richter M, Yumul R, Wang H, Saydaminova K, Ho M, May D, Baldessari A, Gough M, Drescher C, Urban N, Roffler S, Zubieta C, Carter D, Fender P, Lieber A. Preclinical safety and efficacy studies with an affinity-enhanced epithelial junction opener and PEGylated liposomal doxorubicin. Mol Ther Methods Clin Dev. 2015 ; 11 ;2:15005.

Dumas N, Moulin-Sallanon M, Fender P, Tournier BB, Ginovart N, Charnay Y, Millet P. In Vivo Quantification of 5-HT2A Brain Receptors in Mdr1a KO Rats with 123I-R91150 Single-Photon Emission Computed Tomography. Mol Imaging. 2015 ; 14:6-16.

Burmeister WP, Tarbouriech N, Fender P, Contesto-Richefeu C, Peyrefitte CN, Iseni F. Crystal Structure of the Vaccinia Virus Uracil-DNA Glycosylase in Complex with DNA. J Biol Chem. 2015 ; 290(29) : 17923-34

Sumarheni S, Hong SS, Josserand V, Coll JL, Boulanger P, Schoehn G, Fender P. Human Full-Length Coagulation Factor X and a GLA Domain-Derived 40-mer Polypeptide Bind to Different Regions of the Adenovirus Serotype 5 Hexon Capsomer. Hum Gene Ther. 2014 ; 25(4):339-49.

Fender P. Use of dodecahedron "VLPs" as an alternative to the whole adenovirus. Methods Mol Biol. 2014 ;1089:61-70.

Lu ZZ, Wang H, Zhang Y, Cao H, Li Z, Fender P and Lieber A. Penton-Dodecahedral Particles Trigger Opening of Intercellular Junctions and Facilitate Viral Spread during Adenovirus Serotype 3 Infection of Epithelial Cells. PLoS Pathog. 2013 ; 9(10):e1003718

Wang H, Yumul R, Cao H, Ran L, Fan X, Richter M, Epstein F, Gralow J, Zubieta C, Fender P, Lieber A. Structural and Functional Studies on the Interaction of Adenovirus Fiber Knobs and Desmoglein 2. J Virol. 2013 ; 87(21):11346-11362

Fender P, Hall K, Schoehn G and Blair GE. The impact of human adenovirus type 3 dodecahedron on host cells and its potential role in viral infection. J. Virol. 2012. 86(9) : 5380-5

Siqueira-Silva J, Fenel D, Gout E, Yeda F.P, Marinheiro J.C, Barrella K.M, Silva M.L, Schoehn G, Harsi C.M and Fender P. Generation and biological properties of a recombinant dodecahedron containing the short fiber protein of the Human adenovirus 41. Intervirology., 2012 ; 55(5) : 349-55.

Villegas-Méndez A, Fender P, Garin MI, Rothe R, Liguori L, Marques B, Lenormand JL. Functional Characterisation of the WW Minimal Domain for Delivering Therapeutic Proteins by Adenovirus Dodecahedron. PLoS One. 2012 ;7(9):e45416.

Szolajska E, Burmeister WP, Zochowska M, Nerlo B, Andreev I, Schoehn G, Andrieu JP, Fender P, Naskalska A, Zubieta C, Cusack S, Chroboczek J. The structural basis for the integrity of adenovirus ad3 dodecahedron. PLoS One. 2012 ;7(9):e46075

Wang H, Beyer I, Persson J, Song H, Li Z, Richter M, Cao H, van Rensburg R, Yao X, Hudkins K, Yumul R, Zhang XB, Yu M, Fender P, Hemminki A, Lieber A. A New Human DSG2-Transgenic Mouse Model for Studying the Tropism and Pathology of Human Adenoviruses. J. Virol. 2012. 86(11) : 6286-302.

Beyer I, van Rensburg R, Strauss R, Li Z, Wang H, Persson J, Yumul R, Feng Q, Song H, Bartek J, Fender P, Lieber A. Epithelial Junction Opener JO-1 Improves Monoclonal Antibody Therapy of Cancer. Cancer Res. 2011 ; 71(22) : 7080-90

Grellier E, Lécolle K, Rogée S, Couturier C, D’Halluin J.C, Hong S.S, Fender P, Boulanger P, Quesnel B and Colin M. A fiber-modified adenoviral vector interacts with immunoevasion molécules of the B7 family at the surface of murine dormant leukemia cells. Mol Cancer. 2011 ; 10 :105.

Wang H, Li Z, Lara S, Hemminki A, Fender P and Lieber A. Multimerization of adenovirus serotype 3 fiber knob domains is required for efficient binding of virus to desmoglein 2 and subsequent opening of epithelial junctions. J.Virol.. 2011 ; 85(13):6390-40

Corjon S, Gonzalez G, Henning P, Grichine A, Lindholm L, Boulanger PA, Fender P and Hong SS. Cell entry and trafficking of human adenovirus bound to blood factor X is determined by the fiber serotype and not hexon:heparan sulfate interaction. PLoS One. 2011 ; 6(5):e18205

Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14. Wang H, Li ZY, Liu Y, Persson J, Beyer I, Möller T, Koyuncu D, Drescher MR, Strauss R, Zhang XB, Wahl JK 3rd, Urban N, Drescher C, Hemminki A, Fender P, Lieber A. Nat Med. 2011 ; 17(1):96-104

Rogée S, Grellier E, Bernard C, Jouy N, Loyens A, Beauvillain JC, Fender P, Corjon S, Hong SS, Boulanger P, Quesnel B, D’Halluin JC, Colin M. Influence of chimeric human-bovine fibers on adenoviral uptake by liver cells and the antiviral immune response. Gene Ther ; 2010 : 17(7):880-91

Gout E, Schoehn G, Fenel D, Lortat-Jacob H, Fender P. The adenovirus type 3 dodecahedron’s RGD loop comprises an HSPG binding site that influences integrin binding. J Biomed Biotechnol. 2010 ;2010:541939.

Villegas-Mendez A, Garin MI, Pineda-Molina E, Veratti E, Bueren JA, Fender P, Lenormand JL. In vivo delivery of antigens by adenovirus dodecahedron induces cellular and humoral immune responses to elicit antitumor immunity. Mol Ther. 2010 ; 18(5):1046-53.

Siqueira-Silva J, Perez Yeda F, Favier A.L, Mezin P, Silva M.L, Médici Barrella K, Mehnert D.U, Fender P, Hársi C.M. Infection kinetics of human adenovirus serotype 41 in HEK 293 cells . Mem Inst Oswaldo Cruz ; 2009 : 104(5) : 736-744

Fender, P, Schoehn, G, Perron-Sierra, F, Tucker, G, and Lortat-Jacob, H. Adenovirus dodecahedron cell attachment and entry are mediated by heparan sulfate and integrins and vary along the cell cycle. Virol, 2008 ; 371 : 155-164

Fuschiotti, P, Fender, P, Schoehn, G and Conway J. Development of the dodecahedral penton particle from Adenovirus 3 for therapeutic application. J Gen Virol, 2006 ; 87 : 2901-05

Garcel, A, Gout, E, Timmins, J, Chroboczek J, and Fender P. Protein transduction into human cells by adenovirus dodecahedron using WW domains as universal adaptors. Journal of Gene Medicine, 2006 ; 8(4), 524-31

Fuschiotti, P, Schoehn, G, Fender, P, Fabry, C, Hewat, E, Chroboczek, J, Ruigrok, R and Conway J. Structure of the dodecahedral penton particle from human adenovirus type 3. J Mol Biol, 2006 ; 356 (2) : 510-20

Vivès, R, Lortat-Jacob, H, and Fender P. Heparan Sulfate Proteoglycans and viral vectors : ally or foe ? Curr Gene Ther, 2006 ; 6 (1), 35-44.

Fender P, Boussaid A, Mezin P, and Chroboczek J. Synthesis, cellular localisation and quantification of penton-dodecahedron in serotype 3 Adenovirus infected cells. Virology, 2005, sept 340/2 : 167-173

Mahot S, Fender P, Vivès R, Caron C, Perrissin M, Gruffat H, Sergeant A and Drouet E. Cellular Uptake of the EBV transcription factor EB1/Zta. Virus Research, 2005 ; 110, 187-93.

Szolajska E, Poznanski J, López Ferber M, Michalik J, Gout E, Fender P, Bally I, Dublet B and Chroboczek J. Poneratoxin, a neurotoxin from ant venom : structure, expression in insect cells and construction of a bio-insecticide. Eur J Biochem, 2004 Jun ;271(11):2127-36

Fender P. Recombinant adenoviruses and adenovirus penton vectors : from DNA transfer to direct protein delivery into cell. (revue) Gene Ther Mol Biol 2004, Vol 8, 85-90.

Vivès R, Lortat-Jacob , Chroboczek J and Fender P. Heparan Sulphate Proteoglycan mediates the selective attachment and internalisation of serotype 3 adenovirus dodecahedron. Virol, 2004 apr 321/2 : 332-340.

Fender P, Schoehn G, Foucaud-Gamen J, Gout E, Garcel A, Drouet E, and Chroboczek J. Adenovirus dodecahedron allows large multimeric protein transduction in human cells. J.Virol, 2003 Apr 77(8) : 4960-4964.

Fender P, Jeanson L, Ivanov MA, Colin P, Mallet J, Dedieu JF, Latta-Mahieu M. Controlled transgene expression by E1-E4-defective adenovirus vectors harbouring a "tet-on" switch system. J Gene Med. 2002 Nov-Dec ;4(6):668-75.

Zhang F, Andreassen P, Fender P, Geissler E, Hernandez JF, Chroboczek J. A transfecting peptide derived from adenovirus fiber protein. Gene Ther. 1999 Feb ;6(2):171-81.

Fender P, Ruigrok RW, Gout E, Buffet S, Chroboczek J. Adenovirus dodecahedron, a new vector for human gene transfer. Nat Biotechnol. 1997 Jan ;15(1):52-6.

Schoehn G, Fender P, Chroboczek J, Hewat EA. Adenovirus 3 penton dodecahedron exhibits structural changes of the base on fibre binding. EMBO J. 1996 Dec 16 ;15(24):6841-6.

Fender P, Kidd AH, Brebant R, Oberg M, Drouet E, Chroboczek J. Antigenic sites on the receptor-binding domain of human adenovirus type 2 fiber. Virology. 1995 Dec 1 ;214(1):110-7.

Louis N, Fender P, Barge A, Kitts P, Chroboczek J. Cell-binding domain of adenovirus serotype 2 fiber. J Virol. 1994 Jun ;68(6):4104-6.

Chapitres de livres :

Fender P. « Adenovirus Third Edition » 2014 ; Springer (Humana Press)
Chapter 4 : Use of dodecahedron "VLPs" as an alternative to the whole adenovirus.

Fender P, Moriscot C, Ruigrok R and Schoehn G. « Reference Module in Biochemical Research » 2014 ; Elsevier Chapter : « Electron Microscopy of Viruses : Techniques to prepare Viruses and Viral proteins for observation by Electron Microscopy »