Radical chemistry : how radical SAM enzymes control it
L-tyrosine-bound ThiH structure reveals C-C bond break differences within radical SAM aromatic amino acid lyases. Amara P, Saragaglia C, Mouesca JM, Martin L, Nicolet Y. Nature Communications ; 13(1):2284 Contact : Yvain Nicolet( IBS/Metalloproteins group) |
How an enzyme makes room for its substrates
Quinolinate synthase : an example of the roles of the second and outer coordination spheres in enzyme catalysis. Juan C. Fontecilla-Camps* and Anne Volbeda. Chem Rev. (2022) doi : 10.1021/acs.chemrev.1c00869. Contact : Juan Carlos Fontecilla-Camps (IBS/Metalloproteins group) |
Extracellular endosulfatase HSulf-2 harbours a polysaccharide chain that muzzles its pro-tumoral activity
Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan sulfate chain that modulates its enzyme activity. El Masri R, Seffouh A, Roelants C, Seffouh I, Gout E, Pérard J, Dalonneau F, Nishitsuji K, Noborn F, Nikpour M, Larson G, Crétinon Y, Friedel-Arboleas M, Uchimura K, Daniel R, Lortat-Jacob H, Filhol O, Vivès RR. Cell Reports ; 38(11):110516 Contact : Romain Vivès (IBS/Structure and Activity of Glycosaminoglycans Group) |