Institut de Biologie StructuraleGrenoble / France


Tetraploidy and tumor development

Tetreploidy and tumor development

Cancer Cell, Voulme 8, Isuue 5, Novembre 2005, Pages 353-354

Margolis Robert L.

A synthetic heparan sulphate inhibits the biological activity of interferon-gamma (or how to put out fire with sugar).

Heparan sulfate mimicry : a synthetic glycoconjugate that recognizes the heparin binding domain of interferon-gamma inhibits the cytokine activity.
J Biol Chem. (2005) 280 : 37558-37564
Sarrazin S, Bonnaffe D, Lubineau A, Lortat-Jacob H.

Functional role of the linker between the CCP modules of complement protease C1s

Functional role of the linker between the complement control protein modules of complement protease C1s.

Journal of Immunology,. 2005 Oct 1 ;175(7):4536-42.

Bally I, Thielens NM, Gaboriaud C, Arlaud GJ.

21/10/05 : Internal Scientific Workshop

October 21st, 2005 (Domaine Saint Jean de Crépy) :

the IBS organizde its Internal Scientific Workshop, an opportunity to discuss new research themes for the coming years.

October 12-16, 2005 : "Fête de la Science" at the IBS

For the 14th edition the Institute welcomed the general public (adults and secondary school pupils) on the following theme :

Imagery of the living molecules

For more details about the Science Week, please have a look to the :

- official web site of the "Science Week" (in french only)

13/10/05 : "In the heart of the biological molecules : the key of our health !"

October 13rd, 2005 (CRDP, 11 avenue du Général Champon, Grenoble, 6:30 p.m.) :
Eva Pebay-Peyroula, director of the IBS and member of the Academy of _ _ Science will give a conference entitled "In the heart of the biological molecules : the key of our health !".

Structural analysis of PDF enzyme for the design of new antibiotics

The crystal structure of mitochondrial (type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms.
J Biol Chem. 2005 Sep 28
Fieulaine S, Juillan-Binard C, Serero A, Dardel F, Giglione C, Meinnel T, Ferrer JL.

Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line. Molecular analysis of the cleavage site.

It has been recently demonstrated that proteinase 3, a neutrophil-derived serine protease considered as a microbicidal protein, had the ability to cleave the cyclin-dependent kinase inhibitor, p21/waf1. Thus, the couple proteinase 3 and p21 appeared to be crucial in the control of myeloid proliferation and differentiation, with potential involvement in leukemia.

Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line. Molecular analysis of the cleavage site
J Biol Chem. 2005 Aug 26 ;280(34):30242-53.
Dublet B, Ruello A, Pederzoli M, Hajjar E, Courbebaisse M, Canteloup S, Reuter N, Witko-Sarsat

New structural features among the metallo-betalactamase superfamily

Crystal structure of phosphorylcholine esterase domain of the virulence factor choline-binding protein e from streptococcus pneumoniae : new structural features among the metallo-beta-lactamase superfamily.
Biol Chem. 2005 Aug 5 ;280(31):28591-600.
Garau G, Lemaire D, Vernet T, Dideberg O, Di Guilmi AM.

Protein waves

Identification of slow correlated motions in proteins using residual dipolar and hydrogen-bond scalar couplings.

Bouvignies G, Bernado P, Meier S, Cho K, Grzesiek S, Bruschweiler R, Blackledge M.
Proceedings Of The National Academy Of Sciences Of The United States Of America, Volume 102, Issue 39, September 27, 2005, Pages 13885-13890

This publication has been underligned by « Science » in ’Highlight of the Recent Literature’

Structure of SPP, a key enzyme of photosynthesis

The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell.
Plant Cell. 2005 Jul ;17(7):2049-58.
Fieulaine S, Lunn JE, Borel F, Ferrer JL.

Nickel binding by the perilasmic transporter NikA is mediated by a chelator

Crystallographic and spectroscopic evidence for high affinity binding of FeEDTA(H2O)- to the periplasmic nickel transporter NikA.

J Am Chem Soc. 2005 Jul 20 ;127(28):10075-82.

Cherrier MV, Martin L. Cavazza C., Jacquamet L., Lemaire D., Gaillard J., Fontecilla-Camps JC.

Gp36 protein from the feline immunodeficiency virus

Structural characterization of the feline-immunodeficiency-virus envelope glycoprotein 36 ectodomain for the development of new antivirals.

Biochem J. 2005 Jul 15 ;389(Pt 2):559-67.

Desmaris F., Lemaire D., Ricard-Blum S., Chatrenet B. & Forest E.

Heparan sulfate targets the HIV-1 Envelope Glycoprotein gp120 Coreceptor Binding Site

Heparan sulfate targets the HIV-1 envelope glycoprotein gp120 coreceptor binding site.

J Biol Chem. 2005 Jun 3 ;280(22):21353-7. Epub 2005 Mar 28.

Vives R., Imberty A., Sattentau OJ., Lortat-Jacob H.

JBC : paper of the week

The following paper has been selected as a Journal of Biological Chemistry (JBC) Paper of the Week. The paper will appear in the April 8 issue of the journal (which can be viewed online on April 1) :

Effects of p47phoxC Terminus Phosphorylations on Binding Interactions with p40phoxand p67phox : STRUCTURAL AND FUNCTIONAL COMPARISON OF p40phoxand p67phoxSH3 DOMAINS
Claire Massenet, Sylvie Chenavas, Claudine Cohen-Addad, Marie-Claire Dagher, Gerard Brandolin, Eva Pebay-Peyroula, and Franck Fieschi
J. Biol. Chem. 2005 280 : 13752-13761

Molecular Cell

Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein.

Jascur T, Brickner H, Salles-Passador I, Barbier V, El Khissiin A, Smith B, Fotedar R, Fotedar A
Mol Cell. 2005 Jan 21 ;17(2):237-49.

Autrans 2005 (A break in the wall : dissecting membrane protein structure and function)

11th DRDC-IBS Workshop (Autrans, January 26-29, 2005)

Neutron scattering reveals the dynamic basis of protein adaptation to extreme temperature )

Neutron scattering reveals the dynamic basis of protein adaptation to extreme temperature.
J Biol Chem. 2005 Dec 9 ;280(49):40974-9.
Tehei M, Madern D, Franzetti B, Zaccai G