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2006
Crystal structure of HIV-1 protease product complexCrystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates Proceedings of the National Academy of Sciences U S A (2006) 103(49) : 18469 - Das A, Prashar V, Mahale S, Serre L, Ferrer JL, Hosur MV. |
Ultra-high resolution protein structure in solution from residual dipolar couplingsUltrahigh-resolution backbone structure of perdeuterated Ppotein GB1 using residual dipolar couplings from two alignment media. Angewandte Chemie International Edition (2006) 45(48) : 8166-8169 Bouvignies G, Meier S, Grzesiek S and Blackledge M |
Simultaneous Determination of Protein Backbone Structure and Dynamics from Residual Dipolar CouplingsJ. Am. Chem. Soc. ; 2006 ; 128 ; 15100-15101. Bouvignies, G. ; Markwick, P. ; Bruschweiler, R. ; Blackledge, M. |
’Fête de la Science’2006 at the IBSThe 15th edition of the Science Week took place from the 6th to the 15th of October, 2006. For this fifteen edition the Institute welcomed the general public (adults and secondary school pupils). The visit varied from 30mn to 2 hours according to visitors. Topics : Biology, Chemistry, Medicine, Physics For more details about the Science Week, please have a look to the :
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Residual dipolar couplings in short peptides reveal systematic conformational preferences of individual amino acidsJournal of the American Chemical Society (2006) 128(41) : 13508-13514 Dames SA, Aregger R, Vajpai N, Bernado P, Blackledge M and Grzesiek S |
Charge-Induced Molecular Alignment of Intrinsically Disordered ProteinsAngew Chem Int Ed Engl.2006 Oct 27 ;45(42):7012-5 |
Structural basis for the inhibition of HMG synthase by the natural product F244Structural basis for the covalent inhibition of 3-hydrox-3-methylglutaryl-coenzyme A synthase by the b-lactone containing natural product F244. Proceedings of the National Academy of Sciences U S A (2006) 103(31) : 11491-11496 Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ and Noel JP |
PBPs, molecules of interest for drug-designPenicillin Binding Proteins : key players in bacterial cell cycle and drug resistance processes. FEMS Microbiology Reviews (2006) 30(5) : 673-691 Macheboeuf P, Contreras-Martel C, Job V, Dideberg O and Dessen A |
Functional flexibility of B. stearothermophilus formamidopyrimidine DNA-glycosylaseFunctional flexibility of Bacillus stearothermophilus formamidopyrimidine DNA-glycosylase DNA Repair (2006) 5(8) : 947-958 Amara P and Serre L |
A comparative QM/MM simulation study of the reaction mechanisms of human and Plasmodium falciparum HG(X)PRTasesJournal of the American Chemical Society /(2006) 128(31) : 10096-10102 Thomas A and Field MJ |
Structure of allosteric Aspartate kinase
A Novel Organization of ACT Domains in Allosteric Enzymes Revealed by the Crystal Structure of Arabidopsis Aspartate Kinase C. Mas-Droux, G. Curien, M. Robert-Genthon, M. Laurencin1, J.-L. Ferrer, and R. Dumas |
Relations Between Structure and Function of the Mitochondrial ADP/ATP CarrierRelations Between Structure and Function of the Mitochondrial ADP/ATP Carrier Annual Review of Biochemistry Volume 75 : 713-74 75 Nury H, Dahout-Gonzalez C, Trezeguet V, Lauquin GJ, Brandolin G, Pebay-Peyroula E. |
CNRS Silver Medal awarded to E.Pebay-Peyroula
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C1q recognizes C-reactive protein through its globular domainEvidence that complement protein C1q interacts with C-reactive protein through its globular head region. Journal of Immunology (2006) 176(5) : 2950-2957 McGrath FD, Brouwer MC, Arlaud GJ, Daha MR, Hack CE and Roos A |
STLC, a reversible, tight binding inhibitor of the human kinesin Eg5S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression. Journal of Biological Chemistry (2006) 281 : 17559-17569 Skoufias DA, Debonis S, Saoudi Y, Lebeau L, Crevel I, Cross R, Wade RH, Hackney D and Kozielski F |
Structural insights into substrate traffic and inhibition in acetylcholinesteraseStructural insights into substrate traffic and inhibition in acetylcholinesterase. |
High speed three-dimensional protein NMRSpeeding up three-dimensional protein NMR experiments to a few minutes. Journal of the American Chemical Society (2006) 128(28) : 9042-9043 Schanda P, Van Melckebeke H and Brutscher B |
Serendipitous discovery and x-ray structure of a human phosphate binding apolipoproteinSerendipitous discovery and x-ray structure of a human phosphate binding apolipoprotein. Morales R, Berna A, Carpentier P, Contreras-Martel C, Renault F, Nicodeme M, Chesne-Seck ML, Bernier F, Dupuy J, Schaeffer C, Diemer H, Van-Dorsselaer A, Fontecilla-Camps JC, Masson P, Rochu D, Chabriere E. |
Flexibility of Thiamine Diphosphate in pyruvate oxidoreductaseFlexibility of Thiamine Diphosphate Revealed by Kinetic Crystallographic Studies of the Reaction of Pyruvate-Ferredoxin Oxidoreductase with Pyruvate |
Shared architecture of bacteriophage SPO1 and herpesvirus capsidsShared architecture of bacteriophage SPO1 and herpesvirus capsids |
ICarl-Ivar-Brändén Building inauguration
Friday January 13, 2006 from 1:30 to 3:30 p.m. ESRF Auditorium - 6 rue Jules Horowitz – Grenoble – France
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Crystal Structure of Human Iron Regulatory Protein 1 as Cytosolic AconitaseCrystal Structure of Human Iron Regulatory Protein 1 as Cytosolic Aconitase Structure, Volume 14, Issue 1, January 2006, Pages 129-139 |
Crystal structure of iron regulatory protein 1 complexed with ferritin IRE-RNA.Science 2006, 314, 1903-1908 |
