Institut de Biologie StructuraleGrenoble / France

Intrinsic disorder in measles virus nucleocapsids

Researchers of the IBS*, in collaboration with their colleagues of the UVHCI and the AFMB, report the first in situ observation of the intrinsically disordered domain of the nucleoprotein of measles virus. Using nuclear magnetic resonance spectroscopy, small angle scattering, and electron microscopy, they have obtained a structural characterization of the intrinsically disordered C-terminal domain of the nucleoprotein in the context of the entire N-RNA capsid. Their results, published online by PNAS, suggest that this intrinsically disordered part plays an important role in infection by measles virus.
* (Protein Dynamics and Flexibility by NMR Group)

Press release (in french only)

Intrinsic disorder in measles virus nucleocapsids. Malene Ringkjøbing Jensen, Guillaume Communie, Euripedes Almeida Ribeiro Jr, Nicolas Martinez, Ambroise Desfosses, Loïc Salmon, Luca Mollica, Frank Gabel, Marc Jamin, Sonia Longhi, Rob W. H. Ruigrok, and Martin Blackledge. PNAS ;108(24):9839-44.