Institut de Biologie StructuraleGrenoble / France

PhD Theses

The list of PhD theses undertaken in the Entry and Budding of Enveloped Viruses Group can be found year by year below (manuel list).

If you want more details, note that the HAL-IBS website publishes the full content of thesis that are not under embargo or under a particular contractual obligation. The theses of the last 12 months are not yet available on this site and theses prior to 2010 are not exhaustively listed. The PDF avalaible can be consulted HERE.

Manuel list

10/2015 -01/2018 Géraldine Mayeux University Grenoble Alpes

Financement : Bourse de l’Université Grenoble Alpes

Caractérisation biochimique et structurale de la protéine IFITM3, un facteur de restriction antiviral du système immunitaire inné

03/2011 - 04/2015 Nick Aschman University Grenoble Alpes

Financement : Fond National de la Recherche Luxembourg

Publications :
M.G. Bego, É. A. Côt, N. Aschman, J. Mercier, W. Weissenhorn and E. A. Cohen (2015) Human Immunodeficiency Virus Accessory Protein Vpu Inhibits the Antiviral Response of Plasmacytoid Dendritic Cells for Innate Immune Evasion. PLoS Pathogen, 11(7):e1005024.
W. Weissenhorn, N. Miguet, N. Aschman, P. Renesto, Y. Usami, and H.G. Göttlinger (2012) Structural basis for tetherin function. Curr HIV Res. 10(4), 298-306.
N. Aschman, W. Weissenhorn and P. Renesto (2012) La tétherine, dernière amarre du VIH/ Tetherin, last link to HIV. Virologie, 16, 32-42.

10/2010 -09/2013 : Emilie Poudevigne, University Joseph Fourier

Financement : Bourse de l’Université Joseph Fourier

Publications :
J. Solomons, C. Sabin, Y. Usami, E. Poudevigne, D. Lutje-Hulsik, P. Macheboeuf, H.
Gottlinger and W. Weissenhorn (2010) Structural basis of ESCRT-III CHMP3 recruitment
of AMSH. Structure, 19(8), 1149-59.
W. Weissenhorn, E. Poudevigne, G. Effantin and P. Bassereau (2013) How to get out : ssRNA enveloped viruses and membrane fission. Current Opin Virol. 3, 159-167.

8/2009 a 10/2012 : Aurelien Dordor University Joseph Fourier
Financement : DFG

Publications :
G. Effantin*, A. Dordor*, V. Sandrin, N. Martinelli, W.I. Sundquist, G. Schoehn and W. Weissenhorn (2013) ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding. Cell Microbiol., 15(2), 213-26.
* contributed equally)
N. Martinelli,, B. Hartlieb, C. Sabin, A. Dordor, Y. Usami, H. Göttlinger and W. Weissenhorn (2012) CC2D1A is a regulator of ESCRT-III CHMP4B. J. Mol. Biol., 419(1-2), 75-88.
A. Dordor, E. Poudevigne, H. Göttlinger and W. Weissenhorn (2011) Essential and supporting host cell factors for HIV-1 budding. Future Microbiol. 6 (10), 1159-1170

10/2008 à 12/2011 : Nicolas Martinelli University Joseph Fourier
Financement : Région-Rhône-Alpes Cluster 10

Publications :
N. Martinelli,, B. Hartlieb, C. Sabin, A. Dordor, Y. Usami, H. Göttlinger and W. Weissenhorn (2012) CC2D1A is a regulator of ESCRT-III CHMP4B. J. Mol. Biol., 419(1-2), 75-88.
G. Bodon, R. Chassefeyre, K. Pernet-Gallay, N. Martinelli, G. Effantin, D. Lutje Hulsik, A. Belly, Y. Goldberg, C. Chatellard-Causse, B. Blot, G. Schoehn, W. Weissenhorn and R. Sadoul (2011) ESCRT-III CHMP2B polymerizes into helical structures deforming the plasma membrane. J. Boil. Chem. 286(46), 40276-86.
S. Peel, P. Macheboeuf, N. Martinelli and W. Weissenhorn (2011) Divergent pathways lead to ESCRT-III catalyzed membrane fission. Trends in Biochemical Sciences, 36(4), 199-210.
G. Effantin, A. Dordor, V. Sandrin, N. Martinelli, W.I. Sundquist, G. Schoehn and W. Weissenhorn (2013) ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding. Cell Microbiol., 15(2), 213-26.
* contributed equally)

10/2005 à 12/2009 : Miriam Hock Université Philipps de Marburg, Allemagne
Financement : SFB Marburg, DFG
Taux de co-encadrement ( 40 %)
Publications :
M. Hock, I. Kraus, G. Schoehn, M. Jamin, C. Andrei-Selmer, W. Garten and W. Weissenhorn (2010) RNA induced polymerization of the Borna disease virus nucleoprotein. Virology, 397, 64-72.

10/2005 à 09/2011 :Julianna Solomons, Université Joseph Fourier
Financement : EMBL et DFG
Publications :
J. Solomons, et al. W. Weissenhorn (2010) Structural basis of ESCRT-III CHMP3 recruitment of AMSH. Structure, 19(8), 1149-59.
Lata S, Schoehn G, Solomons J, Pires R, Göttlinger HG, Weissenhorn W. (2009) Structure and function of ESCRT-III. Biochem Soc Trans. 37, 156-160.
Lata S, Roessle M, Solomons J, Jamin M, Gottlinger HG, Svergun DI, Weissenhorn W. (2008) Structural basis for autoinhibition of ESCRT-III CHMP3. J Mol Biol. 378, 818-827.

10/2004 à 09/2008 : Ricardo Pires ; EMBL et Université Joseph Fourier
Financement : EMBL et DFG
Publications :
R. Pires, B. Hartlieb, L. Signor, G. Schoehn, S. Lata, M. Roessle, C. Moriscot, S. Popov, A. Hinz, M. Jamin, V. Boyer, R. Sadoul, E. Forest, D. I. Svergun, H. G. Göttlinger and W. Weissenhorn (2009) A crescent shaped ALIX dimer targets ESCRT-III CHMP4 filaments. Structure 17, 843-856.
Lata S, Schoehn G, Solomons J, Pires R, Göttlinger HG, Weissenhorn W. (2009) Structure and function of ESCRT-III. Biochem Soc Trans. 37, 156-160.
Lata S, Schoehn G, Jain A, Pires R, Piehler J, Gottlinger HG, Weissenhorn W. (2008) Helical structures of ESCRT-III are disassembled by VPS4. Science 321, 1354-1357.

11/2002 à 12/2006 : Bettina Hartlieb, Université Philipps de Marburg, Allemagne
Financement : SFB Marburg, German Research Council (DFG)
Taux de co-encadrement ( 20 %)
Publications :
B. Hartlieb, T. Muziol, W. Weissenhorn* and S. Becker* (2007) Crystal structure of the C-terminal domain of Ebola virus VP30 reveals a role in transcription and nucleocapsid assembly. Proc. Natl. Acad. Sci. USA, 104(2), 624-9 (*corresponding authors).
B. Hartlieb and W. Weissenhorn (2006) Filovirus assembly and budding. Virology, 344(1):64-70

10/1999 à 9/2003 : Vassiliy Bavro, Université Joseph Fourier et EMBL
Financement : Bourse Louis-Jeantet Fondation de Médicine ; Genève
Publications :
M. Sola*, V.N. Bavro*, M. Sola, V.N. Bavro, J. Timmins, S. T. Franz, Ricard-Blum, G. Schoehn, R. H.W. Ruigrok, G. A. O’Sullivan, T. Saiyed, B. Schmitt, H. Betz, and W. Weissenhorn (2004) Structural basis of dynamic glycine receptor clustering by gephyrin. EMBO J, 23(13):2510-9 (*equal contribution).
V.N. Bavro, M. Sola, A. Bracher, M. Kneussel, H. Betz, and W. Weissenhorn (2002) Crystal structure of the GABAA receptor associated protein, GABARAP. EMBO Rep. 3, 183-189.

10/1998 à 9/2002 : Joanna Timmins, EMBL et Open University London ;
Financement : EMBL
Publications :
T. Hoenen, V. Volchkov, L. Kolesnikova, E. Mittler, J. Timmins, M. Ottmann, O. Reynard, S. Becker and W. Weissenhorn (2005) VP40 octamers are essential for Ebola virus replication. J. Virol. 79(3), 1898-905.
M. Sola, V.N. Bavro, J. Timmins, et al. W. Weissenhorn (2004) Structural basis of dynamic glycine receptor clustering by gephyrin EMBO J, 23(13):2510-9..
J. Timmins, R.H.W. Ruigrok, and W. Weissenhorn (2004) Structural studies on the Ebola virus matrix protein VP40 indicate that matrix proteins of enveloped RNA viruses are analogues but not homologues. FEMS Microbiol.Lett.15 ; 233(2), 179-86.
J. Timmins, G., Schoehn, C. Kohlhaas, H.-D. Klenk, R.W.H., Ruigrok and W. Weissenhorn (2003) Oligomerization and polymerization of the filovirus matrix protein VP40. Virology, 312, 359-368.
F. X. Gomis-Rüth, A. Dessen, J. Timmins, et al. W. Weissenhorn (2003) The matrix protein VP40 from Ebola virus octamerizes into pore-like structures with specific RNA binding properties. Structure (Cambridge), 11, 423-433.
J. Timmins, et al. W. Weissenhorn (2003) Ebola virus matrix protein VP40 interaction with human cellular factors Tsg101 and Nedd4. J. Mol. Biol. 326, 493-502.
J. Timmins, S. Scianimanico, G. Schoehn, and W. Weissenhorn (2001) Vesicular release of Ebola virus matrix protein VP40. Virology, 283, 1-6.
S. Scianimanico, G. Schoehn, J. Timmins, R. H. W. Ruigrok, H.-D. Klenk, and W. Weissenhorn (2000) Membrane association induces a conformational change in the Ebola virus matrix protein. EMBO J., 19, 6732-6741.

Available PDF for thesis of the Entry and Budding of Enveloped Viruses group