Accueil > Research > Research groups > Protein Dynamics and Flexibility by NMR Group (M.Blackledge) > Protein dynamics in the solid state
Protein dynamics in the solid stateProtein dynamics in the solid stateOver 40000 unique protein structures have been determined by X-ray crystallography, yet little information is available concerning their dynamic behaviour. Solid state NMR can provide atomic resolution information about protein motions occurring on a vast range of timescales under similar conditions to X-ray diffraction studies, and therefore offers a highly complementary approach to characterizing the dynamic fluctuations occurring in the crystal. In collaboration with the Prof. Lyndon Emsley (ENS, Lyon) we develop experimental NMR tools for probing site-specific dynamics in the solid state for example using experiments for measuring 13C relaxation rates as well as for probing slow micro- to millisecond motions. In addition to the experimental developments, we provide analytical tools for the detection of collective motions in the solid state.
Related publications : E. Barbet-Massin, M. Felletti, R. Schneider, S. Jehle, G. Communie, N. Martinez, M.R. Jensen, R.W. Ruigrok, L. Emsley, A. Lesage, M. Blackledge and G. Pintacuda L. Mollica, M. Baias, J.R. Lewandowski, B. J. Wylie, L. J. Sperling, C. M. Rienstra, L. Emsley and M. Blackledge J.R. Lewandowski, H.J. Sass, S. Grzesiek, M. Blackledge and L. Emsley J.R. Lewandowski, J. Sein, H.J. Sass, S. Grzesiek, M. Blackledge and L. Emsley J.R. Lewandowski, J. Sein, M. Blackledge and L. Emsley Updated 12/03/2018 by MRJ |