IBS - Institut de Biologie Structurale - Grenoble / France

Past short-term members

GANDY Lauren — 2025-06-13T14:16:22Z

Short-term members include : master's students (M1/M2), visiting scholars, bachelor/license students (L3), and technicians.

Period	Name	Internship Level	Program - Institute	Main/Sub Supervisors
04-08 /2026	Yannis MARCUZZI	M1	Struct. Biology and Rational Design of Bioactive Molecules - Univ. Montpellier	A. Dos Santos Martins
04-07 /2026	Ludivine LAM	M1	Health Engineering - University. Grenoble-Alpes	L. Imbert / T.S. Chiang
01 - 06 /2026	Haripriya RAKKIAPPAN	M2	Struct. Biology - Univ. Grenoble-Alpes	J. Boisbouvier / L. Gandy
05 - 07 /2025	Titouan MATHEY	L3	Physics - ENS Saclay	L. Cracco & J. Moreira
03 - 07 /2025	Stefano MORASSO	Postdoc	Instruct(EU) / Elettra(IT)	J. Boisbouvier / L. Imbert
02 - 07 /2025	Danming LIU	M2	Struct. Biology - Univ. Montpellier	J. Boisbouvier / A. Mouhand & L. Gandy
01-02 & 06 - 07 /2025	Héloïse BUISSON	M1, CDD	Molecular & Cellular Biology - Claude Bernard Lyon 1	A. Mouhand & L. Gandy
04 - 07 /2024	Agathe CUNIBIL	M1	Chemistry/Biology - Univ. Grenoble-Alpes	B. Vibert
05 - 08 /2023	Sarra DBIRA	M1	PHELMA Grenoble INP	F. Henot & B. Vibert
06 - 07 /2023	Léa MARMOUX	L2	Life Sciences/Biology - Univ. Grenoble-Alpes	A. Audibert
05 - 07 /2022	Irène DOSSOU	M1	Health Sciences and Biotechnology Management - Univ. Grenoble-Alpes	L. Imbert
05 - 07 /2021	Tabitha IRAWAN	L3	Biology - Univ. Grenoble-Alpes	M. Trauchessec & L. Imbert
04 - 07 /2021	Narjess HAIDAR	M1	Biology - Univ. Grenoble-Alpes	A. Giraud

Les conferences

GANDY Lauren — 2024-07-22T09:02:53Z

Sommaire

Conference Organisation

2015-2024 : Lead Organizer of the International Workshop on Advanced
Isotope Labeling Methods (AILM) - Part of CNRS Thematic School
Since 2015 more than 600 researchers have participated to AILM workshops

2016-2022 : Scientific Advisory Board for the International Conference of
Biological Magnetic Resonance

2006/2009 : Co-Organizer for International Workshops on High Field NMR
Spectroscopy for Solids and Liquids (Les Houches, France)

Recent Lectures from NMRLA members

2024 :
Pushing Back the Frontiers of Solution NMR into Biology
Jerome Boisbouvier
Invited seminar at Sanofi R&D (Vitry sur Seine, FR)

Development of a fast and efficient assignment transfer strategy : from a first Fab fragment to other ones
Faustine Henot
Selected oral presentation at AILM2024 Workshop (Grenoble - FR)

Towards an atomic-resolution functional study of the ClpXP machinery in action using cell free and NMR technologies
Astrid Audibert
Selected oral presentation at 48th FEBS Congress (Milan - IT)

2023 :
Human HSP90 a Contortionist Drug Target
Jerome Boisbouvier
Invited lecture at NMR : a tool for Biology conference (Paris, FR)

Visualizing the functional rare states of human HSP90 ATP binding domain
Elisa Rioual
Selected oral presentation at BioNano8 conference (Krakow - PL)

2022 :
Integrated Structural Studies of Large Molecular Machine in Action
Jerome Boisbouvier
Invited lecture at EMBO Practical School : Integrative Structural Biology (Hambourg – GE)

Advanced Isotopic Labeling for the NMR Studies of Large Proteases, Chaperones and Therapeutic Antibodies
Jerome Boisbouvier
Invited lecture at ICMRBS2022 conference (Boston, USA)

Innovative isotopic labeling approaches enabling NMR investigation of monoclonal antibodies at atomic resolution
Arthur Giraud
Selected oral presentation at AILM2022 Workshop (Grenoble - FR)

Visualizing the transiently Populated Closed-State of Human HSP90 ATP Binding Domain
Elisa Rioual
Selected oral presentation at AILM2022 Workshop (Grenoble - FR)

Human HSP90 a contortionist drug target - Modulation of its energy landscape upon ligand binding
Faustine Henot
Selected oral presentation at AILM2022 Workshop (Grenoble - FR)

2021 :
Cell-Free facility - a powerful tool for expression and labelling of challenging targets
Lionel Imbert
Invited lecture at 6th Frisbi user meeting (Paris, FR)

Integration of NMR, kinetic assays and microscopy to investigate inhibition of IAPP fibril formation by co-chaperonin prefoldin
Ricarda Törner
Selected oral presentation at Euromar conference (Virtual).
Invited seminar TU Munich (GE).

Identification of an excited state of the human therapeutic target HSP90 : structural, kinetic and thermodynamic characterization by solution NMR
Faustine Henot
Selected oral presentation at GERM conference (virtual)

Human HSP90 a contortionist drug target - Modulation of its energy landscape upon ligand binding
Faustine Henot
Selected oral presentation at BSI 2021 conference (Paris Saclay – FR)

2020 :
NMR Studies of Large Molecular Machines
Jerome Boisbouvier
Invited seminar at University of Zurich (CH)
Invited lecture at Congreso International de Biologia Estructural, Mexico (Virtual)

2019 :
Structural and Functional Studies of Large Protein Machineries
Jerome Boisbouvier
Invited lecture at NMR : a tool for Biology conference (Paris, FR)

Self-assembly, Structure and Functional Studies of High Molecular Weight Protein Machineries using NMR
Jerome Boisbouvier
Invited seminar IPBS (Toulouse, FR)

Selective edition of inter- and intra- subunit Methyl-NOEs
Ricarda Törner
Selected oral presentation at AILM2019 Workshop (Grenoble - FR)
Invited seminar UCLA California (USA)

In vitro specific labelling of proteins : a powerful tool to study challenging target using NMR spectroscopy
Lionel Imbert
Selected oral presentation at NcAA Symposium Sorbonne Université (Paris, FR)

Les cours et ateliers

GANDY Lauren — 2024-07-22T09:02:52Z

Sommaire

Advanced Isotope Labeling Methods Practical School

The Instruct Practical School for Advanced Isotope Labeling Methods (AILM) was created by Jérôme Boisbouvier and Lionel Imbert in 2015 to provide young biological researchers with practical and theoretical training in state-of-the-art isotopic-labelling approaches for NMR studies. PhD students and post-docs receive hands-on experience in a broad range of labelling methods, including specific labelling, segmental labelling and in vitro expression of RNA and proteins from field-leading experts at the Institut de Biologie Structurale on the beautiful EPN Grenoble campus. The school ran in 2015, 2017, 2019, 2022, and 2024 and has served over 80 trainees, with plans for another in 2026.
For interest in attending the next AILM, please email : lionel.imbert@ibs.fr

Other Advanced Practical Schools for Young Researchers

2024 : Lionel Imbert is an instructor to the Indian-French Winter school on Biomolecular NMR in charge of in vitro isotopic labelling class and practical.

2022 : Jérôme Boisbouvier was an instructor to EMBO Practical School : Integrative Structural Biology (Hambourg – GE). Title of the lecture "Integrated Structural Studies of Large Molecular Machine in Action"

2013-2016 : Jérôme Boisbouvier and Lionel Imbert were instructors for Advanced Practical Schools “Isotopic Labelling of Protein for NMR” in Strasbourg (FR)

2010 : Jérôme Boisbouvier was the main organizer and instructor for an NMR Advanced Practical School “Structural Studies of Proteins by NMR” Grenoble (France)

2009-2011 : Jérôme Boisbouvier was instructor for Advanced Practical Schools “NMR and Biological Interactions” Gif sur Yvette (FR)

University Teaching

2023 : Lionel Imbert gave an overview on cell-free proteins production & facility management to Bologna University (IT) Master students in Industrial Biotechnology

2022- 2024 : Astrid Audibert taught Biochemistry and Cellular Biology to bachelor students at the University of Grenoble-Alpes

2018- : Lionel Imbert organized practicals on Cell-free protein expression for Master students at the University of Grenoble-Alpes

2018-2019 : Lionel Imbert organized practicals on Cell-free protein expression for Master students at the Boston University

2009 - 2018 : Jérôme Boisbouvier served as a lecturer for Biomolecular NMR class (Master 2 level) at the University of Grenoble-Alpes

1998-2000 : Jérôme Boisbouvier taught chemistry to Bachelor and Master students (aggregation level) at the University Joseph Fourier (Grenoble)

Current membership

GANDY Lauren — 2024-07-22T09:00:59Z

To contact any team members, please use the generic e-mail address : firstname.lastname@ibs.fr
To contact Dr. Moreira, please use the following address : jorge.dos-santos-moreira@ibs.fr

Period	Employer	Name	Position
2004-	CNRS	Jérôme Boisbouvier	Researcher DR1
2011-	CNRS	Lionel Imbert	Engineer - IR
2025 -	CEA	Alexandre Dos Santos Martins	Senior Technician
09/22-09/26	Sanofi	Faustine Henot	Post-doc
09/22-08/26	Sanofi	Béatrice Vibert	PhD Student
06/24-11/28	UGA	Lauren Gandy	Post-doc
09/24-12/26	UGA	Basile Moscatello	Engineer (AI)
10/24-09/27	CNRS	Jorge Moreira	Post-doc
10/24-09/27	CEA	Diane D'Esquermes	PhD Student
11/24-10/27	CNRS	Lorenzo Cracco	PhD Student
11/24-10/27	CNRS	Mathilde LePrat	PhD Student
01/26-12/28	CNRS	Tsung-Sheng Chiang	PhD Student
04/26-04/29	CNRS	Tejaswi Koduru	Post-doc
05/26- 05/28	CEA	Xinyao Xiang	Post-doc

Former membership

GANDY Lauren — 2024-07-22T09:00:56Z

Period	Name	Position in the group	Last-known position
02/23-01/26	Karine Giandoreggio	Engineer (AI)
09/24-09/25	Assia Mouhand	Post-doc	Assistant Professor at ICBMS (Lyon, FR)
09/22-08/25	Astrid Audibert	PhD Student	Middle/High School Teacher in Earth and Life Sciences (Dept Yvelines, FR)
01/20-05/24	Arthur Giraud	PhD Student	Permanent researcher at Promise (Grenoble, FR)
10/20-10/23	Elisa Rioual	PhD Student	Post-doc at Riken (Waco, JP)
04/22-11/22	Annelise Vermot	Research Engineer	Laboratory Manager at EMBL (Grenoble, FR)
01/06-09/22	Pierre Gans	CEA Research Director	Retirement
10/18-06/22	Faustine Henot	PhD Student	Post-doc at Sanofi (Vitry-sur-Seine, FR)
10/17-12/21	Ricarda Törner	PhD Student	Post-doc at Harvard Medical School (Boston, MA, USA) ; Assistant Professor at University of Zurich (Zurich, SW)
03/21-12/21	Mathieu Trauchessec	Research Engineer	Permanent researcher at Promise (Grenoble, FR)
03/15-08/20	Rida Awad	Research Engineer	Staff researcher at NMR-Bio (Grenoble,FR)
03/15-05/18	Elisa Colas-Debled	PhD Student	Permanent staff at Tera Environment ; Chemical Engineer at Elicityl (Crolles, FR)
10/12-12/15	Guillaume Mas	PhD Student	Post-doc at Biozentrum (Basel, CH)
09/14-08/15	Caroline Mas	Post-doc	Permanent CNRS Engineer in Biophysics Facility at ISBG (Grenoble, FR)
01/11-10/15	Elodie Crublet	Research Engineer	CEO of NMR-Bio (Grenoble, FR)
10/11-09/15	Rime Kerfah	PhD Student	Co-founder and Staff Researcher at NMR (Grenoble, FR)
01/11-12/14	Pavel Macek	Post-doc	Post-doc at AstraZeneca ; Staff researcher at NMR-Bio ; Staff researcher at KBI Biopharma (Basel, CH)
01/13-06/14	Ombeline Pessey	Engineer Assistant	Engineer at EMBL (Grenoble, FR) ; Permanent Engineer CEA (Saclay, FR)
07/12-12/13	Karine Giandoreggio	Technician	CDI Technician at PX'Therapeutics ; CDI Bgene ; Engineer Assistant at IBS (Grenoble, FR)
10/09-06/13	Matthieu Benoit	PhD Student	Research Asst. Professor at Albert Einstein College (NY, NY, USA)
01/08-09/12	Michael Plevin	Post-doc	Senior Lecturer and Group Leader in the Dept of Biology at University of York (York, UK)
09/09-08/11	Maria-Rosa Quintero	Post-doc	Communication and Scientiﬁc Culture Manager at Aconit (Grenoble, FR) and Service Culturel, Mairie de Voiron (Voiron, FR)
06/08-03/10	Carlos Amero Tello	Post-doc	Professor and Group Leader at Universidad Autonoma del Estado de Mexico(Cuernavaca, MX)
06/06-07/08	Rodolfo Rasia	Post-doc	Group Leader at Institute of Molecular and Cellular Biology of Rosario (Rosario, AR)
04/05-03/06	Helene Van Melkebeke	Post-doc	Post-doc at ETH Zurich (Zurich, SW)
10/04-07/08	Remy Sounier	PhD Student	Post-doc at Harvard Medical School (Boston, MA, USA) ; INSERM permanent Research Associate at IGF Montepllier (Montpellier, FR) ; Guest Researcher at Karolinska Institute (Sola, SW)
09/04-01/06	Matthew Devany	Post-doc	Director of NMR Spectroscopy Facility of The City University of New York (NY, NY, USA)

National and Regional Funding

GANDY Lauren — 2024-07-22T08:58:52Z

2025-2028 ANR
Deciphering Complex Protein Energy Landscapes at Atomic Resolution with Novel AI-Enhanced and Advanced High-Pressure NMR Tools
Partner

2024-2027 CEA
PhD Fellowship (Diane d'Esquermes)

2023-2026 ANR
Development of innovative NMR methods enabling in-depth characterization of therapeutic antibodies batches
Coordinator

2024-2027 UGA/ENS-Lyon
PhD Fellowship (Astrid Audibert)

2021-2022 La Ligue contre le Cancer (charity) – Extension of PhD fellowship (F. Henot)

2020-2021 Fondation pour la Recherche Médicale (charity)
Extension of PhD fellowship (Ricarda Törner)

2019-2024 Région Auvergne Rhône Alpes Pack Ambition Recherche
Integrating protein dynamics into the rational drug design process
Coordinator

2019-2024 ANR
Targeting ClpP proteases : From dynamics and function to allosteric modulation by drugs
Partner

2018-2021 ANR
Methylene resonances : invaluable probes for the study of proteins
Partner

2017-2020 UGA/IDEX International Strategic Partnership Grant
Chaperonin Interactions with Amyloidogenic and Aggregate-prone proteins
Coordinator

2015-2018 CEA
PhD Fellowship (Elisa Colas-Debled)

2013-2015 ANRS
The eIF3 complex as a target for a strategy to inhibit Hepatitis C Virus (HCV) IRES-dependent translation by RNA aptamers C
Partner

2012-2015 UGA
PhD Fellowship (Guillaume Mas)

2012-2013 ARC - Fondation pour la recherche contre le cancer (Charity)
Extension of PhD fellowship Matthieu Benoit

2009-2012 ANR
Real-Time Studies of Biological NanoMachines in Action by NMR
Coordinator

2009-2012 CEA
PhD Fellowship (Matthieu Benoit)

2008-2011 ARC - Fondation pour la recherche contre le cancer (Charity)
Post-doctoral Fellowship (Michael Plevin)

2008-2010 ANRS
Fonctional and Structural Studies of RNP complexes involved in translation intitiation of Hepatitisis C
Partner

2007-2008 CNRS Interdisciplinary Program
Hyperthermophilic Machineries in Action : A Real-time NMR Approach
Coordinator

2006-2010 ANR
RNA Shape Recognition and Structure in MicroRNA Processing
Coordinator

2005-2006 ANRS
Post-doctoral Fellowship (Helene Van Melckebeke)

2004-2008 UGA
PhD Fellowship (Remy Sounier)

2005-2006 CNRS
Post-doctoral Fellowship (Matthew Devany)

International Funding

GANDY Lauren — 2024-07-22T08:58:51Z

2026-2028 MSCA European Postdoctoral Fellowship
Pinpoint-NMR : A sequence-specific labeling technique to accelerate NMR investigation of large proteins (L. Gandy)

2024-2029 ERC Advanced Grant
New Routes for the Solution NMR Investigations of Extra Large Biomolecular Assemblies
Coordinator

2017-2020 EC/H2020
INFRADEV-InstructULTRA (partner)

2014-2015 ERC Proof of Concept
Commercialization and Dissemination of Innovative Isotopic Labelling Solutions and Services for the NMR Studies of Important Protein Targets
Coordinator

2012-2014 EC/FP7/PEOPLE
European Fellowship (P. Macek)

2011-2016 ERC Consolidator Category
Real-Time Studies of Biological NanoMachines in Action by NMR
Coordinator

2009-2010 EC/FP7/PEOPLE
International Rapatriation Grant (M. Plevin)

2009-2010 CONACYT (Mexico)
Post-doctoral Fellowship (Carlos Amero)

2006-2010 HFSP Young Investigator Grant
RNA Shape Recognition and Structure in MicroRNA Processing
Coordinator

2006-2009 French Canada Research Fund / CNRS / CIHR
Structural study of the complex between the TAR loop of HIV RNA and its aptamer TAR*GA by NMR in liquid crystalline medium
Coordinator

2006-2008 ECOS / SECYT / CNRS / CONICET
Collaborative Funds with Argentina
RNA Shape Recognition and Structure in MicroRNA Processing
Coordinator

2004-2007 HFSP Career Development Award
Quaternary Structure Study of Large complexes using Liquid Crystal and Cross-Correlated NMR
Coordinator

2001-2003 HFSP
Post-doctoral Fellowship (J. Boisbouvier)

Collaborations

GANDY Lauren — 2024-07-22T08:58:49Z

Sommaire

Current

2024 - Ewen Lescop – ICSN (Gif sur Yvette, FR)
2022 - Carine Tisné and Pierre Barraud – IBPC (Paris, FR)
2020 - Guillaume Bouvignies – ENS (Paris, FR)
2020 - Oriane Frances and Camille Doyen – Sanofi (Vitry sur Seine, Paris)
2019 - Claire Loison - ILM (Lyon, FR)
2018 - Matthias Frech (Merck KGaA) – Darmstadt (GE)
2015- G. Shoehn – IBS (Grenoble, FR)
2019- Chris Chipot and François Dehez – LIA (Nancy, FR)

Former

2019-2023 Pau Bernado – CBS (Montpellier, FR)
2016-2023 Adrien Favier – IBS (Grenoble, FR)
2016-2021 Emeric Miclet – Universities Sorbonne (Paris, FR)
2015-2020 Elodie Crublet and Rime Kerfah – NMR-Bio (Grenoble, FR)
2015-2022 Wolfgang Hoyer and Dieter Willbold – University of Dusseldorf (GE)
2013-2018 Michael Plevin – University of York (UK)
2011-2016 Carlos Amero – Univeristy of Morelos (Mexico)
2011-2015 Rodolfo Rasia – IBR (Rosario, Argentina)
2009-2020 Olivier Hamelin – LCBM/CEA (Grenoble, FR)
2009-2011 Pascale Legault – University of Montreal (Canada)
2008-2015 Emanuel Drouet and Julien Perard – IVMS (Grenoble, FR)
2007-2012 Bruno Franzetti and Thierry Vernet- IBS (Grenoble, FR)
2006-2018 David Bryce – University of Ottawa (Canada)
2005-2013 Javier Palatnik – IBR (Rosario, Argentina)
2005-2020 Bernhard Brutscher and Paul Schanda - IBS (Grenoble, FR)
2003-2008 Jean-Jacques Toulmé – IECB (Bordeaux, FR)

Industrial Transfer and Partnership

GANDY Lauren — 2024-07-22T08:58:48Z

2023-2026 Sanofi
CIFRE thesis of B. Vibert (Supervision J. Boisbouvier /O. Frances)
Innovative tools for NMR characterization of glycosylated therapeutic antibodies at the atomic scale

2022-2024 UGA/IDEX Innovation Grant
Support for the collaboration IBS/Sanofi
New NMR tool for characterizing therapeutic antibodies in industry

2022-2025 Sanofi
Post-doctoral position F. Henot (Supervision J. Boisbouvier / C. Doyen / O. Frances)
Design of innovative tools for the NMR study of therapeutic antibodies at atomic resolution

2020-2023 Sanofi
CIFRE thesis of A. Giraud (Supervision J. Boisbouvier / E. Crublet / O. Frances)
Development of innovative isotope labeling approaches for NMR characterization of monoclonal antibodies (mAbs) produced in CHO cells (CIFRE)

2018-2021 UGA/IDEX Innovation Grant
Support for the collaboration IBS/NMR-Bio/Merck
Development of Innovative NMR tools based on methyl specific labeling allowing an efficient screening of drugs - Coordinator

2017-2021 Merck KGaA
Collaboration
Structure and Dynamics studies of human HSP90 drug target

2017 Patent :
“Cell-free synthesis of isotopic labelled proteins from amino-acids precursors“. WO2018157942A. Boisbouvier J., Crublet E., Gans P., Imbert L. ; Kerfah R.

2016-2020 NMR-Bio
J. Boisbouvier : Founding member, Scientific Advisor and Collaborator.
Development of new CH3-NMR methods for the study of large proteins

2016 Patent :
"Méthode de préparation de milieux de culture riches pour le marquage d'acides aminés incorporés dans des protéines." French Patent FR 1657906. Awad R, Boisbouvier J., Gans P, Hamelin O, Kerfah R.

2015-2016 Servier
Collaboration
In vitro production of protein for NMR studies

2014-2015 ERC Proof of Concept
Grant supporting the creation of NMR-Bio spin'off
Commercialization and Dissemination of Innovative Isotopic Labelling Solutions and Services for the NMR Studies of Important Protein Targets – Coordinator

2012-2014 CEA
Support scale-up of patented technologies
Support to Industrial Partnerships

2012 Patent
“Labeled Chiral alpha-hydroxy ketoacid derivatives, a process for preparing derivatives and their use." EU Patent #12305984.2. Boisbouvier J., Gans P, Kerfah R, Pessey O, Plevin M.

2011-2012 CNRS
Support to finalize patent
Support to Industrial Technological Transfer

2010 Patent
“Process for the Specific Isotopic Labeling of Methyl Groups of Val, Leu and Ile." WO 2011/083356. Ayala I, Boisbouvier J, Gans P, Hamelin O..