IBS - Institut de Biologie Structurale - Grenoble / France

Présentation

2022-10-20T11:57:26Z

Sommaire

Présentation

Bienvenue sur la page web du groupe Flexibilité et Dynamique des Protéines de l'IBS, dirigé par Martin Blackledge.

La dynamique conformationelle des protéines gouverne l'activité biologique des protéines et par là même les processus essentiels à la vie. Le mouvement des protéines joue un role clef dans les interactions moléculaires, dans la stabilité thermodynamique des états fonctionnels, dans les processus de reconnaissance impliquant une transition d'un état non-structuré vers un état structuré, dans les phénomènes d'allostérie et de signalisation moléculaire, ou les mouvements corrélés peuvent servir de vecteur au transfert d'information entre des sites éloignés au sein d'une même protéine.

La Résonance Magnétique Nucléaire (RMN) constitue un outil de choix pour étudier de tels processus. Elle permet en effet de collecter, en phase liquide ou solide, une riche palette d'informations sur le mouvement local au sein de protéines aussi bien ordonnées que désordonnées.

Les thématiques de recherche du groupe se focalisent donc sur l'étude de la flexibilité conformationnelle des protéines dans leurs différentes formes et sur la compréhension du lien complexe qui peut exister entre le mouvement moléculaire et le fonctionnement ou le dysfonctionnement des protéines. Actuellement les thèmes de recherche concernent, en relation avec leur fonction biologique, aussi bien l'analyse à haute résolution du paysage énergétique lié aux modifications conformationnelles des protéines repliées que l'étude du comportement extrêmement flexible des protéines intrinsèquement désordonnées.

Mots clefs

Résonance Magnétique Nucléaire (RMN), flexibilité conformationnelle, protéine intrinsèquement désordonnée, dynamique des protéines, détermination de structure, repliement des protéines, dynamique fonctionnelle.

Protéines intrinsèquement désordonnées

Administrateur du site — 2022-10-11T09:45:44Z

Prière de consulter la version anglaise.

Membres du groupe

2022-09-23T08:21:26Z

Sommaire

Personnel permanent

Martin Blackledge (Directeur de recherche, cadre superieur CEA)

Robert Schneider (CEA)

Patricia Amara (CEA) ORCID

Damien Maurin (Ingenieur CNRS)

Personnel contractuel

Aldo Camacho Zarcho (Postdoctorant)

Frederik Theisen (Postdoctorant)

Nitin Kachariya (Postdoctorant)

Shivangi Shukla (Thesarde)

Lefan Yu (Thesarde)

Yi-Hsin Chen (Thesarde)

Publications

2019-04-19T14:19:24Z

Sommaire

Publications depuis 2014

La liste des publications du groupe "Flexibilité et Dynamique des Protéines par RMN", parues dans des revues à comité de lecture depuis 2014, ainsi que les ouvrages et chapitres d'ouvrage, est consultable ci-dessous (données issues de HAL-IBS).
L'affichage peut prendre quelques secondes. Pour consulter les diverses années, utiliser la barre de défilement intérieure.

Publications jusqu'à 2013

La liste des publications du groupe de 2000 à 2013 est visible ci-dessous (données saisies de façon manuelle).

Publications 2013

Agirre J, Goret G, Legoff M, Sanchez-Eugenia R, Marti G, Navaza J, Guerin D and Neumann E
Cryo-TEM reconstructions of Triatoma Virus particles : a clue to unravel genome delivery and capsid disassembly.
Journal of General Virology (2013) 94(5) : 1058-1068

Appolaire A, Rosenbaum E, Dura MA, Colombo M, Marty V, Noirclerc Savoye M, Godfroy A, Schoehn G, Girard E, Gabel F and Franzetti B
Pyrococcus horikoshii TET2 peptidase assembling process and associated functional regulation.
Journal of Biological Chemistry (2013) 288(31) : 22542-22554

Bally I, Ancelet S, Moriscota C, Gonnet F, Mantovani A, Daniele R,
Schoehn G, Arlaud GJ, and Thielen NM
Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites.
Proceedings of the National Academy of Sciences (2013) 110(21) : 8650-8655

Desfosses A, Ribeiro EA, Jr., Schoehn G, Blondel D, Guilligay D, Jamin M, Ruigrok RW and Gutsche I
Self-organization of the vesicular stomatitis virus nucleocapsid into a bullet shape.
Nature Communications (2013) 4 : 1429

Effantin G, Dordor A, Sandrin V, Martinelli N, Sundquist WI, Schoehn G and Weissenhorn W
ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding.
Cellular Microbiology (2013) 15(2) : 213-226

Effantin G, Hamasaki R, Kawasaki T, Bacia M, Moriscot C, Weissenhorn W, Yamada T and Schoehn G
Cryo-electron microscopy three-dimensional structure of the jumbo phage ΦRSL1 infecting the phytopathogen Ralstonia solanacearum.
Structure (2013) 21(2) : 298-305

Estrozi LF, Settembre EC, Goret G, McClain B, Zhang X, Chen JZ, Grigorieff N and Harrison SC
Location of the dsRNA-dependent polymerase, VP1, in rotavirus particles.
Journal of Molecular Biology (2013) 425(1) : 124-132

Gogonea V, Gerstenecker GS, Wu ZP, Lee X, Topbas C, Wagner MA, Tallant TC, Smith JD, Callow P, Pipich V, Malet H, Schoehn G, DiDonato JA and Hazen SL
The low-resolution structure of nHDL reconstituted with DMPC with and without cholesterol reveals a mechanism for particle expansion.
Journal of Lipid Research (2013) 54(4) : 966-983

Portran D, Zoccoler M, Gaillard J, Stoppin-Mellet V, Neumann E, Arnal I, Martiel JL and Vantard M
MAP65/Ase1 promote microtubule flexibility.
Molecular Biology of the Cell (2013) 24(12) : 1964-1973

Serriere J, Fenel D, Schoehn G, Gouet P and Guillon C
Biophysical characterization of the feline immunodeficiency virus p24 capsid protein conformation and in vitro capsid assembly.
PLoS One (2013) 8(2) : e56424

Szurgot I, Szolajska E, Laurin D, Lambrecht B, Chaperot L, Schoehn G and Chroboczek J
Self-adjuvanting influenza candidate vaccine presenting epitopes for cell-mediated immunity on a proteinaceous multivalent nanoplatform.
Vaccine (2013) 31(40) : 4338-4346

Thill A, Guiose B, Bacia-Verloop M, Geertsen V and Belloni L
How the diameter and structure of (OH)3Al2O3SixGe1–xOH imogolite nanotubes are controlled by an adhesion versus curvature competition.
The Journal of Physical Chemistry C (2013) 116(51) : 26841-26849

Trapani S and Navaza J
Fourier-space TEM reconstructions with symmetry adapted functions for all rotational point groups.
Journal of Structural Biology (2013) 182(2) : 87-92

von Loeffelholz O, Knoops K, Ariosa A, Zhang X, Karuppasamy M, Huard K, Schoehn G, Berger I, Shan SO and Schaffitzel C
Structural basis of signal sequence surveillance and selection by the SRP-FtsY complex.
Nature Structural & Molecular Biology (2013) 20(5) : 604-610

Publications 2012

Fender P, Hall K, Schoehn G and Blair GE
Impact of human adenovirus type 3 dodecahedron on host cells and its potential role in viral infection.
Journal of Virology (2012) 86(9) : 5380-5385

Galinier R, van Beurden S, Amilhat E, Castric J, Schoehn G, Verneau O, Fazio G, Allienne JF, Engelsma M, Sasal P and Faliex E
Complete genomic sequence and taxonomic position of eel virus European X (EVEX), a rhabdovirus of European eel.
Virus Research (2012) 166(1-2) : 1-12

Germi R, Effantin G, Grossi L, Ruigrok RWH, Morand P and Schoehn G
Three-dimensional structure of the Epstein-Barr virus capsid.
Journal of General Virology (2012) 93(8) : 1769-1773

Knoops K, Schoehn G and Schaffitzel C
Cryo-electron microscopy of ribosomal complexes in cotranslational folding, targeting, and translocation.
Wiley Interdisciplinary Reviews RNA (2012) 3(3) : 429-441

Ling WL, Cherns PD, Samuel J, Raccurt O, Poncelet O and Chabli A
Z-contrast cryo-electron tomography probes shell porosity in multi-shell nanocomposites.
Journal of Nanoparticle Research (2012) 14(4) : 806

Maitre M, Weidmann S, Rieu A, Fenel D, Schoehn G, Ebel C, Coves J and Guzzo J
The oligomer plasticity of the small heat-shock protein Lo18 from Oenococcus oeni influences its role in both membrane stabilization and protein protection.
Biochemical Journal (2012) 444(1) : 97-104

Navarro FP, Berger M, Guillermet S, Josserand V, Guyon L, Neumann E, Coll JLR, P. and Texier I
Lipid nanoparticule vectorization of indocyanine green improves fluorescence imaging for tumor diagnosis and lymph node resection.
Journal of Biomedical Nanotechnology (2012) 8(5) : 730-741

Siqueira-Silva J, Fenel D, Gout E, Yeda FP, Marinheiro JC, Barrella KM, Silva ML, Schoehn G, Harsi CM and Fender P
Generation and biological properties of a recombinant dodecahedron containing the short fiber protein of the human adenovirus 41.
Intervirology (2012) 55(5) : 349-355

Szolajska E, Burmeister WP, Zochowska M, Nerlo B, Andreev I, Schoehn G, Andrieu JP, Fender P, Naskalska A, Zubieta C, Cusack S and Chroboczek J
The structural basis for the integrity of adenovirus ad3 dodecahedron.
PLoS One (2012) 7(9) : e46075

Publications 2011

Agirre J, Aloria K, Arizmendi JM, Iloro I, Elortza F, Sánchez-Eugenia R, Marti GA, Neumann E, Rey FA and Guérin DMA
Capsid protein identification and analysis of mature Triatoma virus (TrV) virions and naturally occurring empty particles.
Virology(2011) 409(1) : 91-101

Arlaud GJ, Biro A and Ling WL
Enzymatically modified low-density lipoprotein is recognized by C1q and activates the classical complement pathway.
Journal of Lipids (2011) 2011 : 376092

Bayle L, Chimalapati S, Schoehn G, Brown J, Vernet T and Durmort C
Zinc uptake by Streptococcus pneumoniae depends on both AdcA and AdcAII and is essential for normal bacterial morphology and virulence.
Molecular Microbiology (2011) 82 (4) : 904-916

Beaune G, Tamang S, Bernardin A, Bayle-Guillemaud P, Fenel D, Schoehn G, Vinet F, Reiss P and Texier I
Luminescence of polyethylene glycol coated CdSeTe/ZnS and InP/ZnS nanoparticles in the presence of copper cations.
Chemphyschem (2011) 12 (12) : 2247-2254

Bodon G, Chassefeyre R, Pernet-Gallay K, Martinelli N, Effantin G, Hulsik DL, Belly A, Goldberg Y, Chatellard-Causse C, Blot B, Schoehn G, Weissenhorn W and Sadoul R
Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane.
Journal of Biological Chemistry (2011) 286(46) : 40276-40286

Chouquet A, Paidassi H, Ling WL, Frachet P, Houen G, Arlaud GJ and Gaboriaud C
X-ray structure of the human calreticulin globular domain reveals a Peptide-binding area and suggests a multi-molecular mechanism.
PLoS One (2011) 6(3) : e17886

Delmas T, Couffin AC, Bayle PA, Crecy FD, Neumann E, Vinet F, Bardet M, Bibette J and Texier I
Preparation and characterization of highly stable lipid nanoparticles with amorphous core of tuneable viscosity.
Journal of Colloid and Interface Sciences (2011) 360 (2) : 471-481

Desfosses A, Goret G, Farias Estrozi L, Ruigrok RW and Gutsche I
Nucleoprotein-RNA orientation in the measles virus nucleocapsid by three-dimensional electron microscopy.
Journal of Virology (2011) 85(3) : 1391-1395

Gaillard J, Ramabhadran V, Neumann E, Gurel P, Blanchoin L, Vantard M and Higgs HN
Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules.
Molecular Biology of the Cell (2011) 22 (23) : 4575-4587

Gout E, Moriscot C, Doni A, Dumestre-Perard C, Lacroix M, Perard J, Schoehn G, Mantovani A, Arlaud GJ and Thielens NM
M-Ficolin interacts with the long pentraxin PTX3 : A novel case of cross-talk between soluble pattern-recognition molecules.
Journal of Immunology (2011) 186 (10) : 5815-5822

Ling WL, Biro A, Bally I, Tacnet P, Deniaud A, Doris E, Frachet P, Schoehn G, Pebay-Peyroula E and Arlaud GJ
Proteins of the innate immune system crystallize on carbon nanotubes but are not activated.
ACS Nano (2011) 5 (2) : 730-737

Mackiewicz N, Bark T, Cao B, Delaire JA, Riehl D, Ling WL, Foillard S and Doris E
Fullerene-functionalized carbon nanotubes as improved optical limiting devices.
Carbon (2011) 49 (12) : 3998-4003

Moriscot C, Gribaldo S, Jault JM, Krupovic M, Arnaud J, Jamin M, Schoehn G, Forterre P, Weissenhorn W and Renesto P
Crenarchaeal CdvA forms double-helical filaments containing DNA and interacts with ESCRT-III-like CdvB.
PLoS One (2011) 6 (7) : e21921

Moulès V, Terrier O, Yver M, Riteau B, Moriscot C, Ferraris O, Julien T, Giudice E, Rolland J-P, Erny A, Bouscambert-Duchamp M, Frobert E, Rosa-Calatrava M, Pu Lin Y, Hay A, Thomas D, Schoehn G and Lina B
Importance of viral genomic composition in modulating glycoprotein content on the surface of influenza virus particles.
Virology (2011) 414 (1) : 51-62

Païdassi H, Tacnet-Delorme P, Verneret M, Gaboriaud C, Houen G, Duus K, Ling WL, Arlaud GJ and Frachet P
Investigations on the C1q-calreticulin-phosphatidylserine interactions yield new insights into apoptotic cell recognition.
Journal of Molecular Biology (2011) 408 (2) : 277-290

Publications 2010

Bartual SG, Garcia-Doval C, Alonso J, Schoehn G and van Raaij MJ
Two-chaperone assisted soluble expression and purification of the bacteriophage T4 long tail fibre protein gp37.
Protein Expression and Purification (2010) 70(1) : 116-121

Effantin G, Figueroa-Bossi N, Schoehn G, Bossi L and Conway JF
The tripartite capsid gene of Salmonella phage Gifsy-2 yields a capsid assembly pathway engaging features from HK97 and [lambda].
Virology (2010) 402(2) : 355-365

El Bakkouri M, Gutsche I, Kanjee U, Zhao B, Yu M, Goret G, Schoehn G, Burmeister WP and Houry WA
Structure of RavA MoxR AAA+ protein reveals the design principles of a molecular cage modulating the inducible lysine decarboxylase activity.
Proceedings of the National Academy of Sciences (2010) 107(52) : 22499-22504

Erlich P, Dumestre-Perard C, Ling WL, Lemaire-Vieille C, Schoehn G, Arlaud GJ, Thielens NM, Gagnon J and Cesbron JY
Complement protein C1q forms a complex with cytotoxic prion protein oligomers.
Journal of Biological Chemistry (2010) 285(25) : 19267-19276

Estrozi LF and Navaza J
Ab initio high-resolution single-particle 3D reconstructions : The symmetry-adapted-functions way.
Journal of Structural Biology (2010) 172(3) : 253-260

Fache V, Gaillard J, Van Damme D, Geelen D, Neumann E, Stoppin-Mellet V and Vantard M
Arabidopsis kinetochore fiber-associated MAP65-4 cross-links microtubules and promotes microtubule bundle elongation.
Plant Cell (2010) 22(11) : 3804-3815

Fould B, Garlatti V, Neumann E, Fenel D, Gaboriaud C and Arlaud GJ
Structural and functional characterization of the recombinant human mitochondrial trifunctional protein.
Biochemistry (2010) 49(39) : 8608-8617

Funke SA, van Groen T, Kadish I, Bartnik D, Nagel-Steger L, Brener O, Sehl T, Batra-Safferling R, Moriscot C, Schoehn G, Horn AHC, Muller-Schiffmann A, Korth C, Sticht H and Willbold D
Oral treatment with the D-enantiomeric peptide D3 improves the pathology and behavior of alzheimer's disease transgenic mice.
ACS Chemical Neuroscience (2010) 1(9) : 639-648

Galan Bartual S, Garcia-Doval C, Alonso J, Schoehn G and van Raaij MJ
Two-chaperone assisted soluble expression and purification of the bacteriophage T4 long tail fibre protein gp37.
Protein Expression and Purification (2010) 70(1) : 116-121

Gout E, Schoehn G, Fenel D, Lortat-Jacob H and Fender P
The adenovirus type 3 dodecahedron's RGD loop comprises an HSPG binding site that influences integrin binding.
Journal of Biomedicine and Biotechnology (2010) 2010 : 541939

Hock M, Kraus I, Schoehn G, Jamin M, Andrei-Selmer C, Garten W and Weissenhorn W
RNA induced polymerization of the Borna disease virus nucleoprotein.
Virology (2010) 397(1) : 64-72

Moules V, Ferraris O, Terrier O, Giudice E, Yver M, Rolland JP, Bouscambert-Duchamp M, Bergeron C, Ottmann M, Fournier E, Traversier A, Boule C, Rivoire A, Lin Y, Hay A, Valette M, Marquet R, Rosa-Calatrava M, Naffakh N, Schoehn G, Thomas D and Lina B
In vitro characterization of naturally occurring influenza H3NA- viruses lacking the NA gene segment : Toward a new mechanism of viral resistance ?
Virology (2010) 404(2) : 215-224

Muller-Schiffmann A, Marz-Berberich J, Andreyeva A, Ronicke R, Bartnik D, Brener O, Kutzsche J, Horn AH, Hellmert M, Polkowska J, Gottmann K, Reymann KG, Funke SA, Nagel-Steger L, Moriscot C, Schoehn G, Sticht H, Willbold D, Schrader T and Korth C
Combining independent drug classes into superior, synergistically acting hybrid molecules.
Angewandte Chemie International Edition (2010) 49(46) : 8743-8746

Rebowski G, Namgoong S, Boczkowska M, Leavis PC, Navaza J and Dominguez R
Structure of a longitudinal actin dimer assembled by tandem W domains : Implications for actin filament nucleation.
Journal of Molecular Biology (2010) 403(1) : 11-23

Samuel J, Raccurt O, Poncelet O, Auger A, Ling WL, Cherns P, Grunwald D and Tillement O
Surface characterizations of fluorescent-functionalized silica nanoparticles : from the macroscale to the nanoscale.
Journal of Nanoparticle Research (2010) 12 : 2255-2265

Samuel J, Tallec G, Cherns P, Ling WL, Raccurt O, Poncelet O, Imbert D and Mazzanti M
Lanthanide-chelate silica nanospheres as robust multicolor Vis-NIR tags.
Chemical Communications (Camb) (2010) 46(15) : 2647-2649

Trapani S, Schoehn G, Navaza J and Abergel C
Macromolecular crystal data phased by negative-stained electron-microscopy reconstructions.
Acta Crystallographica D Biological Crystallography (2010) 66(Pt 5) : 514-521

Publications 2009

Chandran V, Fronzes R, Duquerroy S, Cronin N, Navaza J and Waksman G
Crystal structure of the outer membrane complex of a type IV secretion system.
Nature (2009) 462(7276) : 1011-1015

Duquerroy S, Da Costa B, Henry C, Vigouroux A, Libersou S, Lepault J, Navaza J, Delmas B and Rey FA
The picobirnavirus crystal structure provides functional insights into virion assembly and cell entry.
Embo Journal (2009) 28(11) : 1655-1665

Fabry CM, Rosa-Calatrava M, Moriscot C, Ruigrok RW, Boulanger P and Schoehn G
The C-terminal domains of adenovirus serotype 5 protein IX assemble into an antiparallel structure on the facets of the capsid.
Journal Of Virology (2009) 83(2) : 1135-1139

Hinz A, Schoehn G, Quendler H, Hulsik DL, Stiegler G, Katinger H, Seaman MS, Montefiori D and Weissenhorn W
Characterization of a trimeric MPER containing HIV-1 gp41 antigen.
Virology (2009) 390(2) : 221-227

Kumaran D, Eswaramoorthy S, Furey W, Navaza J, Sax M and Swaminathan S
Domain organization in Clostridium botulinum neurotoxin type E is unique : its implication in faster translocation.
Journal of Molecular Biology (2009) 386(1) : 233-245

Lata S, Schoehn G, Solomons J, Pires R, Gottlinger HG and Weissenhorn W
Structure and function of ESCRT-III.
Biochemical Society Transactions (2009) 37(Pt 1) : 156-160

Pires R, Hartlieb B, Signor L, Schoehn G, Lata S, Roessle M, Moriscot C, Popov S, Hinz A, Jamin M, Boyer V, Sadoul R, Forest E, Svergun DI, Gottlinger HG and Weissenhorn W
A crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments.
Structure (2009) 17(6) : 843-856

Sancey L, Garanger E, Foillard S, Schoehn G, Hurbin A, Albiges-Rizo C, Boturyn D, Souchier C, Grichine A, Dumy P and Coll JL
Clustering and internalization of integrin [alpha]v[beta]3 with a tetrameric RGD-synthetic peptide.
Molecular Therapy (2009) 17(5) : 837-843

Siebert X and Navaza J
UROX 2.0 : an interactive tool for fitting atomic models into electron-microscopy reconstructions.
Acta Crystallographica Section D-Biological Crystallography (2009) 65(7) : 651-658

Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, Mennechet F, Schoehn G, Lortat-Jacob H, Dreja H, Ibanes S, Kalatzis V, Wang JP, Finberg RW, Cusack S and Kremer EJ
The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution.
PLoS Pathogens (2009) 5(1) : e1000277

Texier I, Goutayer M, Da Silva A, Guyon L, Djaker N, Josserand V, Neumann E, Bibette J and Vinet F
Cyanine-loaded lipid nanoparticles for improved in vivo fluorescence imaging.
Journal of Biomedical Optics (2009) 14(5) : 054005

Zochowska M, Paca A, Schoehn G, Andrieu JP, Chroboczek J and Szolajska E
Adenovirus dodecahedron, a drug transfer vector.
PLoS ONE (2009) 4(5) : e5569

Publications 2008

El Bakkouri M, Seiradake E, Cusack S, Ruigrok RWH and Schoehn G
Structure of the C-terminal head domain of the fowl adenovirus type 1 short fibre.
Virology (2008) 378(1) : 169-176

Estrozi LF and Navaza J
Fast projection matching for cryo-electron microscopy image reconstruction.
Journal of Structural Biology (2008) 162(2) : 324-334

Estrozi LF, Neumann E, Squires G, Rozas-Dennis G, Costabel M, Rey FA, Guerin DM and Navaza J
Phasing of the Triatoma virus diffraction data using a cryo-electron microscopy reconstruction.
Virology (2008) 375(1) : 85-93

Franqueville L, Henning P, Magnusson M, Vigne E, Schoehn G, Blair-Zajdel ME, Habib N, Lindholm L, Blair GE, Hong SS and Boulanger P
Protein crystals in Adenovirus type 5-infected cells : requirements for intranuclear crystallogenesis, structural and functional analysis.
PLoS ONE (2008) 3(8) : e2894

Gaillard J, Neumann E, Van Damme D, Stoppin-Mellet V, Ebel C, Barbier E, Geelen D and Vantard M
Two microtubule-associated proteins of Arabidopsis MAP65s promote anti-parallel microtubule bundling.
Molecular Biology of the Cell (2008) 19(10) : 4534-4544

Lata S, Schoehn G, Jain A, Pires R, Piehler J, Gottlinger HG and Weissenhorn W
Helical structures of ESCRT-III are disassembled by VPS4.
Science (2008) 321(5894) : 1354-1357

Libersou S, Siebert X, Ouldali M, Estrozi LF, Navaza J, Charpilienne A, Garnier P, Poncet D and Lepault J
Geometric mismatches within the concentric layers of rotavirus particles : a potential regulatory switch of viral particle transcription activity.
Journal Of Virology (2008) 82(6) : 2844-2852

Manzano C, Contreras-Martel C, El Mortaji L, Izoré T, Fenel D, Vernet T, Schoehn G, Di Guilmi AM and Dessen A
Sortase-mediated pilus fiber biogenesis in Streptococcus pneumoniae.
Structure (2008) 16(12) : 1838-1848

Navaza J
Combining X-ray and electron-microscopy data to solve crystal structures.
Acta Crystallographica D Biological Crystallography (2008) 64(Pt 1) : 70-75

Pous J, Urpi L, Subirana JA, Gouyette C, Navaza J and Campos JL
Stabilization by extra-helical thymines of a DNA duplex with hoogsteen base pairs.
Journal of the American Chemical Society (2008) 130(21) : 6755-6760

Schoehn G, El Bakkouri M, Fabry CM, Billet O, Estrozi LF, Le L, Curiel DT, Kajava AV, Ruigrok RW and Kremer EJ
3D structure of canine adenovirus serotype 2 capsid.
Journal Of Virology (2008) 82(7) : 3192-3203

Trapani S and Navaza J
AMoRe : classical and modern.
Acta Crystallographica D Biological Crystallography (2008) 64(Pt 1) : 11-16

Publications 2007

Estrozi LF, Trapani S and Navaza J
SCA : symmetry-based center assignment of 2D projections of symmetric 3D objects.
Journal of Structural Biology (2007) 157(2) : 339-347

Hewat EA, Durmort C, Jacquamet L, Concord E and Gulino-Debrac D
Architecture of the VE-cadherin Hexamer.
Journal of Molecular Biology (2007) 365(3) : 744-751

Monzani PS, Trapani S, Thiemann OH and Oliva G
Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase.
BMC Structural Biology (2007) 7(1) : 59

Stoppin-Mellet V, Gaillard J, Timmers T, Neumann E, Conway J and Vantard M
Arabidopsis katanin binds microtubules using a multimeric microtubule-binding domain.
Plant Physiology and Biochemistry (2007) 45(12) : 867-877

Trapani S, Siebert X and Navaza J
The concept of resolution in the domain of rotations.
Acta Crystallographica A (2007) 63(Pt 2) : 126-130

Publications 2006

Brier S, Carletti E, Debonis S, Hewat E, Lemaire D and Kozielski F
The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins.
Biochemistry (2006) 45(51) : 15644-15653

Duda RL, Hendrix RW, Huang WM and Conway JF
Shared architecture of bacteriophage SPO1 and herpesvirus capsids.
Curreny Biology (2006) 16(1) : R11-13

Effantin G, Boulanger P, Neumann E, Letellier L and Conway J
Bacteriophage T5 structure reveals similarities with HK97 and T4 suggesting evolutionary relationships.
Journal of Molecular Biology (2006) 361(5) : 993-1002

Faudry E, Vernier G, Neumann E, Forge V and Attree I
Synergistic pore formation by type III toxin translocators of Pseudomonas aeruginosa.
Biochemistry (2006) 45(26) : 8117-8123

Fuschiotti P, Schoehn G, Fender P, Fabry CM, Hewat EA, Chroboczek J, Ruigrok RW and Conway JF
Structure of the dodecahedral penton particle from human adenovirus type 3.
Journal of Molecular Biology (2006) 356(2) : 510-520

Fuschiotti P, Schoehn G, Fender P, Ruigrok RW, Chroboczek J and Conway JF
Development of the dodecahedral penton particle from Adenovirus 3 for therapeutic application.
Journal of General Virology (2006) 87(10) : 2901-2905

Harris A, Belnap DM, Watts NR, Conway JF, Cheng N, Stahl SJ, Vethanayagam JG, Wingfield PT and Steven AC
Epitope diversity of hepatitis B virus capsids : quasi-equivalent variations in spike epitopes and binding of different antibodies to the same epitope.
Journal of Molecular Biology (2006) 355(3) : 562-576

Hewat EA and Blaas D
Nonneutralizing human Rhinovirus serotype 2-specific monoclonal antibody 2G2 attaches to the region that undergoes the most dramatic changes upon release of the viral RNA.
Journal Of Virology (2006) 80(24) : 12398-12401

Hewat EA, Durmort C, Jacquamet L, Concord E and Gulino-Debrac D
Architecture of the VE-cadherin Hexamer.
Journal Molecular Biology (2006) 365(3) : 744-751

Neumann E, Garcia-Saez I, Debonis S, Wade RH, Kozielski F and Conway JF
Human kinetochore-associated kinesin CENP-E visualized at 17 A resolution bBound to microtubules.
Journal of Molecular Biology (2006) 362(2) : 203-211

Suhre K, Navaza J and Sanejouand YH
NORMA : A tool for flexible fitting of high-resolution protein structures into low-resolution electron-microscopy-derived density maps.
Acta Crystallographica Section D : Biological Crystallography (2006) 62(9) : 1098-1100

Wikoff WR, Conway JF, Tang J, Lee KK, Gan L, Cheng N, Duda RL, Hendrix RW, Steven AC and Johnson JE
Time-resolved molecular dynamics of bacteriophage HK97 capsid maturation interpreted by electron cryo-microscopy and X-ray crystallography.
Journal of Structural Biology (2006) 153(3) : 300-306

Publications 2005

Bruemmer A, Scholari F, Lopez-Ferber M, Conway JF and Hewat EA
Structure of an insect parvovirus (junonia coenia densovirus) determined by cryo-electron microscopy
Journal of Molecular Biology (2005) 347(4) : 791-801

Fabry CMS, Rosa-Calatrava M, Conway JF, Zubieta C, Cusack S, Ruigrok RW and Schoehn G
A quasi-atomic model of human Adenovirus type 5 capsid.
EMBO Journal (2005) 24(9) : 1645-1654

Li YY, Conway JF, Cheng N, Steven AC, Hendrix RW and Duda RL
Control of virus assembly : HK97 "Whiffleball" mutant capsids without pentons
Journal of Molecular Biology (2005) 348(1) : 167-182

Plisson C, Uzest M, Drucker M, Froissart R, Dumas C, Conway J F, Thomas D, Blanc S and Bron P
Structure of the mature P3-virus particle complex of Cauliflower mosaic virus revealed by cryo-electron microscopy
Journal of Molecular Biology (2005) 346(1) : 267-277

Quinaud M, Chabert J, Faudry E, Neumann E, Lemaire D, Pastor A, Elsen S, Dessen A and Attree I
The PscE-PscF-PscG complex controls type III secretion needle biogenesis in Pseudomonas aeruginosa.
Journal of Biological Chemistry (2005) 280(43) : 36293-36300

Robin G, Debonis S, Dornier A, Cappello G, Ebel C, Wade RH, Thierry-Mieg D and Kozielski F
Essential Kinesins : Characterization of Caenorhabditis elegans KLP-15
Biochemistry (2005) 44(17) : 6526-6536

Ross PD, Cheng N, Conway JF, Firek B, Hendrix RW, Duda RL and Steven AC
Crosslinking renders bacteriophage HK97 capsid maturation irreversible and effects an essential stabilization
EMBO Journal (2005) 24(7) : 1352-1363

Ruigrok RW, Schoehn G and Conway JF (2005)
The morphology and structure of viruses in Microbiology and microbial infections : virology, édité par Mahy B and Meulen V. pp. 57-85

Steven AC, Conway JF, Cheng N, Watts NR, Belnap DM, Harris A, Stahl SJ and Wingfield PT
Structure, assembly and antigenicity of hepatitis B virus capsid proteins.
Advances in Virus Research. Virus Assembly (2005) 64 : 125-164

Steven AC, Heymann JB, Cheng N, Trus BL and Conway JF
Virus maturation : dynamics and mechanism of a stabilizing structural transition that leads to infectivity
Current Opinion in Structural Biology (2005) 15(2) : 227-236

Unser M, Sorzano COS, Thevenaz P, Jonic S, El-Bez C, de Carlo S, Conway JF and Trus BL
Spectral signal-to-noise ratio and resolution assessment of 3d reconstructions
Journal of Structural Biology (2005) 149(3) : 243-255

Publications 2004

Al-Kurdi R, Gulino-Debrac D, Martel L, Legrand J-F, Renault A, Hewat E and Venien-Bryan C
A Soluble VE-cadherin Fragment Forms 2D Arrays of Dimers upon Binding to a Lipid Monolayer
Journal of Molecular Biology (2004) 337(4) : 881-892

Brier S, Lemaire D, Debonis S, Forest E and Kozielski F
Identification of the protein binding region of S-Trityl-l-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.
Biochemistry (2004) 43(41) : 13072 - 82

DeBonis S, Skoufias D A, Lebeau L, Lopez R, Robin G, Margolis R L, Wade R H and Kozielski F
In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.
Molecular Cancer Therapeutics (2004) 3(9) : 1079-1090

Gan L, Conway J, Firek B, Cheng N, Hendrix R, Steven A, Johnson J and Duda R
Control of crosslinking by quaternary structure changes during bacteriophage HK97 maturation.
Molecular Cell (2004) 14(5) : 559 - 69

Garcia-Saez I, Blot D, Kahn R and Kozielski F
Crystallization and preliminary crystallographic analysis of the motor domain of human kinetochore-associated protein CENP-E using an automated crystallization procedure
Acta Crystallographica Biological Crystallography D (2004) 60(Part 6) : 1158-1160

Garcia-Saez I, Yen T, Wade R and Kozielski F
Crystal Structure of the Motor Domain of the Human Kinetochore Protein CENP-E.
Journal of Molecular Biology (2004) 340(5) : 1107 - 16

Hewat E A and Blaas D
Cryoelectron microscopy analysis of the structural changes associated with human rhinovirus type 14 uncoating
Journal of Virology (2004) 78(6) : 2935-42

Heymann J B, Conway J F and Steven a C
Molecular dynamics of protein complexes from four-dimensional cryo-electron microscopy
Journal of Structural Biology (2004) 147 : 291-301

Jacquamet L, Ohana J, Joly J, Borel F, Pirocchi M, Charrault P, Bertoni A, Israel-Gouy P, Carpentier P, Kozielski F, Blot D and Ferrer J
Automated analysis of vapor diffusion crystallization drops with an x-ray beam.
Structure (Camb) (2004) 12(7) : 1219 - 1225

Schoehn G, Mavrakis M, Albertini A, Wade R, Hoenger A and Ruigrok R W H
The 12Å structure of trypsin treated measles virus N-RNA
Journal of Molecular Biology (2004) 339(2) : 301-312

Publications 2003

Balakireva L, Schoehn G, Thouvenin E and Chroboczek J
Binding of adenovirus capsid to dipalmitoyl phosphatidylcholine provides a novel pathway for virus entry
Journal Of Virology (2003) 77(8) : 4858-4866

Belnap D M, Watts N R, Conway J F, Cheng N, Stahl S J, Wingfield P T and Steven a C
Diversity of core antigen epitopes of hepatitis B virus
Proceedings of the National Academy of Sciences U S A (2003) 100(19) : 10884-9

Cerritelli M E, Conway J F, Cheng N, Trus B L and Steven a C
Molecular mechanisms in bacteriophage T7 procapsid assembly, maturation, and DNA containment
Advances in Protein Chemistry (2003) 64 : 301-323

Cerritelli ME, Trus BL, Smith CS, Cheng N, Conway JF and Steven AC
A second symmetry mismatch at the portal vertex of Bacteriophage T7 : 8-fold symmetry in the procapsid core
Journal of Molecular Biology (2003) 327(1) : 1-6

Conway JF, Watts NR, Belnap DM, Cheng N, Stahl SJ, Wingfield PT and Steven AC
Characterization of a conformational epitope on hepatitis B virus core antigen and quasiequivalent variations in antibody binding
Journal Of Virology (2003) 77(11) : 6466-6473

DeBonis S, Simorre JP, Crevel I, Lebeau L, Skoufias DA, Blangy A, Ebel C, Gans P, Cross R, Hackney DD, Wade RH and Kozielski F
Interaction of the mitotic inhibitor monastrol with human kinesin Eg5
Biochemistry (2003) 42(2) : 338-49

Hewat EA
The bacteriophage PRD1 uses a pseudo-beta propeller to bind to its cellular receptor.
Structure (Camb) (2003) 11(3) : 239-40

Hewat EA
Rhinovirus-receptor interactions in Handbook on Cell Signalling (2003), édité par Wilson I., Academic Press

Neumann E, Moser R, Snyers L, Blaas D and Hewat EA
A cellular receptor of human rhinovirus type 2, the very-low-density lipoprotein receptor, binds to two neighboring proteins of the viral capsid
Journal of Virology (2003) 77(15) : 8504-8511

Vlasak M, Blomqvist S, Hovi T, Hewat E and Blaas D
Sequence and structure of human rhinoviruses reveal the basis of receptor discrimination
Journal of Virology (2003) 77(12) : 6923-6930

Publications 2002

Bibert S, Jaquinod M, Concord E, Ebel C, Hewat E, Vanbelle C, Legrand P, Weidenhaupt M, Vernet T and Gulino-Debrac D
Synergy between extracellular modules of VE cadherin promotes homotypic hexameric interactions
Journal of Biological Chemistry (2002) 277(15) : 12790-12801

Hewat E and Neumann E
Characterization of the performance of a 200-kV field emission gun for cryo-electron microscopy of biological molecules
Journal of Structural Biology (2002) 139(1) : 60

Hewat E, Neumann E and Blaas D
The Concerted Conformational Changes during Human Rhinovirus 2 Uncoating.
Molecular Cell (2002) 10(2) : 317

Wade R
Sequence landmark patterns identify and characterize protein families
Structure (London, England) (2002) 10(10) : 1329

Watts NR, Conway JF, Cheng NQ, Stahl SJ, Belnap DM, Steven AC and Wingfield PT
The morphogenic linker peptide of HBV capsid protein forms a mobile array on the interior surface
Embo Journal (2002) 21(5) : 876-884

Publications 2001

Charpilienne A, Nejmeddine M, Berois M, Parez N, Neumann E, Hewat E, Trugnan G and Cohen J
Individual rotavirus-like particles containing 120 molecules of fluorescent protein are visible in living cells
Journal of Biological Chemistry (2001) 276(31) : 29361-7

Conway, J. F., Wikoff, W. R., Cheng, N., Duda, R. L., Hendrix, R. W., Johnson, J. E. and Steven, A. C.
Virus maturation involving large subunit rotations and local refolding.
Science (2001) 292(5517) : 744-8

Hewat E and D Blaas
Structural studies on antibody interacting with viruses
Current Topics Microbiology and Immunology (2001) 260 : 29-44

Kozielski F, Svergun D, Zaccai G, Wade RH and Koch MH
The Overall Conformation of Conventional Kinesins Studied by Small- Angle X-Ray and Neutron Scattering
Journal of Biological Chemistry (2001) 276(2) : 1267-1275

Legrand P, Bibert S, Jaquinod M, Ebel C, Hewat E, Vincent F, Vanbelle C, Concord E, Vernet T and Gulino D
Self-assembly of the Vascular Endothelial Cadherin Ectodomain in a Ca2+- dependent Hexameric Structure
Journal of Biological Chemistry (2001) 276(5) : 3581-3588

Meurer-Grob, P., Kasparian, J. and Wade, R. H.
Microtubule structure at improved resolution.
Biochemistry (2001) 40(27) : 8000-8

Svergun, D. I., Zaccai, G., Malfois, M., Wade, R. H., Koch, M. H. and Kozielski, F.
Conformation of the Drosophila motor protein non-claret disjunctional in solution from X-ray and neutron scattering.
Journal of Biological Chemistry (2001) 276(27) : 24826-32

Thouvenin, E., Schoehn, G., Rey, F., Petitpas, I., Mathieu, M., Vaney, M. C., Cohen, J., Kohli, E., Pothier, P. and Hewat, E.
Antibody inhibition of the transcriptase activity of the rotavirus DLP : a structural view.
Journal of Molecular Biology (2001) 307(1) : 161-72

Publications 2000

Belnap, D. M., Filman, D. J., Trus, B. L., Cheng, N., Booy, F. P., Conway, J. F., Curry, S., Hiremath, C. N., Tsang, S. K., Steven, A. C. and Hogle, J. M.
Molecular tectonic model of virus structural transitions : the putative cell entry states of poliovirus.
Journal of Virology (2000) 74(3) : 1342-54

Hewat, E. A., Neumann, E., Conway, J. F., Moser, R., Ronacher, B., Marlovits, T. C. and Blaas, D.
The cellular receptor to human rhinovirus 2 binds around the 5-fold axis and not in the canyon : a structural view.
Embo Journal (2000) 19(23) : 6317-25

Lata, R., J. F. Conway, N. Cheng, R. L. Duda, R. W. Hendrix, W. R. Wikoff, J. E. Johnson, H. Tsuruta and A. C. Steven
Maturation dynamics of a viral capsid : visualization of transitional intermediate states.
Cell (2000) 100(2) : 253-63

Thouvenin E and Hewat E
When two into one won't go : fitting in the presence of steric hindrance and partial occupancy
Acta Crystallogr D Biol Crystallogr (2000) 56(Pt 10) : 1350-1357

Wade RH and Kozielski F
Structural links to kinesin directionality and movement
Nature Structural Biology (2000) 7(6) : 456-60

Yang, F., P. Forrer, Z. Dauter, J. F. Conway, N. Cheng, M. E. Cerritelli, A. C. Steven, A. Pluckthun and A. Wlodawer
Novel fold and capsid-binding properties of the lambda-phage display platform protein gpD.
Nature Structural Biology (2000) 7(3) : 230-7

Thèses FDP

2009-08-27T14:52:22Z

Sommaire

Toutes nos thèses

La liste des thèses soutenues dans le groupe Flexibilité et Dynamique des Protéines par RMN depuis sa création est disponible année par année ci-dessous (récapitulatif manuel).

2021

Wiktor Adamski
Investigating the relationship between intrinsic protein disorder and biological
function : Mapping interaction trajectories at atomic resolution using nuclear magnetic
resonance spectroscopy and molecular simulation.
Thesis Université Grenoble Alpes, defended 8th of October 2021

Serafima Guseva
Multi-scale studies of Measles virus nucleocapsid assembly.
Thesis Université Grenoble Alpes, defended 18th of May 2021

2019

Stefaniia Ivashchenkoi
Investigating the role of conformational disorder in mumps virus proteins.
Thesis Université Grenoble Alpes, defended 1st of July 2021

2016

Anton Abyzov
Nuclear magnetic resonance studies of the dynamics and thermodynamics of intrinsically disordered proteins.
Thesis Université Grenoble Alpes, defended 11th of March 2016.

2015

Elise Delaforge
Dynamique structurale et fonctionnelle du domaine C-terminal de la protéine PB2 du virus de la grippe A.
Thesis Université Grenoble Alpes, defended 4th of December 2015.

2014

Kragelj Jaka
Structure and dynamics of intrinsically disordered regions of MAPK signalling proteins. Thèse de doctorat de l'Université Grenoble Alpes, soutenue le 11 Décembre 2014.

2013

Communie Guillaume
Ordre et Désordre, bases structurales de la reconnaissance moléculaire chez les paramyxovirus. Thèse de doctorat de l'Université Grenoble Alpes, soutenue le 24 octobre 2013.

2012

Ozenne Valery
Etude de la dynamique conformationnelle des protéines intrinsèquement désordonnées par résonance magnétique nucléaire. Thèse de doctorat de l'Université Joseph Fourier, soutenue le 28 novembre 2012.

2010

Salmon Loic
Du désordre conformationnel des protéines structurées et intrinsèquement désordonnées par résonance magnétique nucléaire. Thèse de doctorat de l'Université Joseph Fourier, Grenoble I, soutenue le 26 novembre 2010.

Accéder au texte intégral de nos thèses

Pour de plus amples informations, le site HAL-IBS publie les PDF des thèses qui ne sont pas sous embargo ou sous une obligation contractuelle particulière et pour lesquelles les auteurs ont autorisé la publication sur HAL. Vous les trouverez ci-dessous (l'affichage peut prendre quelques secondes).
Merci de noter que les thèses des 12 derniers mois ne sont pas encore disponibles sur ce site et les thèses antérieures à 2010 n'y figurent pas de façon exhaustive.
Pour consulter les diverses années, utiliser la barre de défilement intérieure.

Outils analytiques développés par le groupe

Administrateur du site — 2008-12-24T09:14:58Z

Prière de consulter la version anglaise.

Dynamique de reconnaissance moléculaire

Administrateur du site — 2008-12-24T09:12:55Z

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Dynamique des protéines dans l'etat solide

Administrateur du site — 2008-12-24T09:09:45Z

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Dynamique des protéines multi-domaines

Administrateur du site — 2008-12-24T09:08:33Z

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