Thèses

2022-11-17T16:26:08Z

Sommaire

Toutes nos thèses

La liste des thèses soutenues dans le groupe Épigénétique et voies moléculaires est disponible année par année ci-dessous.

2024

Hasan Dawi
Développement d'une nouvelle stratégie antifongique contre un superchampignon émergent mortel.
Thèse de doctorat de l'Université de Grenoble Alpes, soutenue le 15 octobre 2024.

2023

Raphaël Dupeyron
Étude structurale du remodeleur de la chromatine RSC chez Candida albicans.
Thèse de doctorat de l'Université de Grenoble Alpes, soutenue le 17 octobre 2023.

Jean-Baptiste Izquierdo
Étude biochimique et structurale du complexe PRC2 et de la protéine ULTRAPETALA1, deux régulateurs antagonistes de la chromatine chez Arapidopsis thaliana.
Thèse de doctorat de l'Université de Grenoble Alpes, soutenue le 12 octobre 2023.

2022

Hamida Laroussi
Caractérisation biochimique des protéines REC114, MEI4 et IHO1 impliquées dans l'initiation de la recombinaison méiotique chez la souris.
Thèse de doctorat de l'Université de Grenoble Alpes, soutenue le 7 décembre 2022.

2020

Kaiyao Wei
Développement d'une nouvelle stratégie antifongique ciblant un domaine de lecture épigénétique.
Thèse de doctorat de l'Université de Grenoble Alpes, soutenue le 8 octobre 2020.

2017

Mizar Oliva
Analyse biochimique et de spectrométrie de masse d'un complexe d'export de ribonucléoprotéines du VIH-1.
Thèse de doctorat de l'Université de Grenoble Alpes, soutenue le 23 mai 2017

2015

Didier Spittler
Étude de l'interaction entre la protéine humaine Importin beta et la protéine du VIH-1 Rev.
Thèse de doctorat de l'Université de Grenoble, soutenue le 29 septembre 2015

2014

Francesca Coscia
La symétrisation des protéines : un nouvel outil pour la biologie structurale.
Thèse de doctorat de l'Université de Grenoble, soutenue le 4 décembre 2014.

Accéder au texte intégral de nos thèses

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Merci de noter que les thèses des 12 derniers mois ne sont pas encore disponibles sur ce site.
Pour consulter les diverses années, utiliser la barre de défilement intérieure.

Publications

2022-11-17T16:19:09Z

Sommaire

Publications depuis 2014

La liste des publications du groupe Épigénétique et voies moléculaires, parues dans des revues à comité de lecture depuis 2014, ainsi que les ouvrages et chapitres d'ouvrage, est consultable ci-dessous (données issues de HAL-IBS).
L'affichage peut prendre quelques secondes. Pour consulter les diverses années, utiliser la barre de défilement intérieure.

Publications jusqu'à 2013

La liste des publications du groupe de 2000 à 2013 est visible ci-dessous (données saisies de façon manuelle).

Publications 2013

Dian C, Bernaudat F, Langer K, Oliva Mizar F, Fornerod M, Schoehn G, Müller Christoph W and Petosa C
Structure of a truncation mutant of the nuclear export factor CRM1 provides insights into the auto-inhibitory role of its C-terminal helix.
Structure (2013) 8(6) : 1338–1349

Emadali A, Rousseaux S, Bruder-Costa J, Rome C, Duley S, Hamaidia S, Betton P, Debernardi A, Leroux D, Bernay B, Kieffer-Jaquinod S, Combes F, Ferri E, McKenna CE, Petosa C, Bruley C, Garin J, Ferro M, Gressin R, Callanan MB and Khochbin S
Identification of a novel BET bromodomain inhibitor-sensitive, gene regulatory circuit that controls Rituximab response and tumour growth in aggressive lymphoid cancers.
EMBO Molecular Medicine (2013) 5(8) : 1180-1195

Goutte-Gattat D, Shuaib M, Ouararhni K, Gautier T, Skoufias DA, Hamiche A and Dimitrov S
Phosphorylation of the CENP-A amino-terminus in mitotic centromeric chromatin is required for kinetochore function.
Proceedings of the National Academy of Sciences (2013) 110(21) : 8579-8584

Indorato R-L, DeBonis S, Kozielski F, Garcia-Saez I and Skoufias DA
STLC-resistant cell lines as tools to classify chemically divergent Eg5 targeting agents according to their mode of action and target specificity.
Biochemical Pharmacology (2013) 86(10) : 1441–1451

Ma P, Varela F, Magoch M, Silva AR, Rosario AL, Brito J, Oliveira TF, Nogly P, Pessanha M, Stelter M, Kletzin A, Henderson PJ and Archer M
An efficient strategy for small-scale screening and production of archaeal membrane transport proteins in Escherichia coli.
_ PLoS One (2013) 8(10) : e76913

Mädler S, Boeri Erba E, Zenobi R
MALDI-ToF Mass spectrometry for studying noncovalent complexes of biomolecules.
Topics in Current Chemistry (2013) 331 : 1-36

Montellier E, Boussouar F, Rousseaux S, Zhang K, Buchou T, Fenaille F, Shiota H, Debernardi A, Hery P, Curtet S, Jamshidikia M, Barral S, Holota H, Bergon A, Lopez F, Guardiola P, Pernet K, Imbert J, Petosa C, Tan M, Zhao Y, Gerard M and Khochbin S
Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B.
Genes & Development (2013) 27(15) : 1680-1692

Noirclerc-Savoye M, Lantez V, Signor L, Philippe J, Vernet T and Zapun A
Reconstitution of membrane protein complexes involved in pneumococcal septal cell wall assembly.
PLoS One (2013) 8(9) : e75522

Parent A, Caux-Thang C, Signor L, Clémancey M, Sethu R, Blondin G, Maldivi P, Duarte V, Latour J-M
A single aspartate to glutamate mutation makes Fur sensitive to H2O2 as PerR.
Angewandte Chemie Int. Ed (2013) 52 : 10339-10343

Radzimanowski J, Dehez F, Round A, Bidon-Chanal A, McSweeney S and Timmins J
An 'open' structure of the RecOR complex supports ssDNA binding within the core of the complex.
Nucleic Acids Research (2013) 41(16) : 7972-7986

Repetto D*, Aramu S*, Boeri Erba E*, Sharma N, Jensen ON, Cabodi S, Turco E, Di Stefano P, Defilippi P
Mapping of p140Cap phosphorylation sites : The EPLYA and EGLYA motifs have a key role in tyrosine phosphorylation and Csk binding, and are substrates of the Abl kinase.
PLoS ONE (2013) 8(1):e54931.
* equal contributors.

Signor L, Boeri Erba E
Mass spectrometric analysis of intact proteins larger than 100 kDa.
Journal of Visualized Experiments (2013) 79 : e50635

Stelter M, Acajjaoui S, McSweeney S and Timmins J
Structural and mechanistic insight into DNA unwinding by Deinococcus radiodurans UvrD.
PLoS One (2013) 8(10) : e77364

Zapun A, Philippe J, Abrahams K, Signor L, Roper D, Breukink E, Vernet T
In vitro reconstitution of peptidoglycan assembly from the Gram-positive pathogen Streptococcus pneumoniae.
ACS Chemical Biology (2013) 8(12) : 2688–2696.

Publications 2012

Brand GD, Salbo R, Jørgensen TJ, Bloch C Jr, Boeri Erba E, Robinson CV, Tanjoni I, Moura-da-Silva AM, Roepstorff P, Domont GB, Perales J, Valente RH, Neves-Ferreira AG
The interaction of the antitoxin DM43 with a snake venom metalloproteinase analyzed by mass spectrometry and surface plasmon resonance.
Journal of Mass Spectrometry (2012) 47(5) : 567-573

Dach I, Olesen C, Signor L, Nissen P, le Maire M, Moller JV and Ebel C
Active detergent solubilized H+,K+-ATPase is a monomer.
Journal of Biological Chemistry (2012) 287(50) : 41963-41978

Gendrin C, Contreras-Martel C, Bouillot S, Elsen S, Lemaire D, Skoufias DA,
Huber P, Attree I, Dessen A
Structural basis of cytotoxicity mediated by the
type III secretion toxin ExoU from Pseudomonas aeruginosa.
PLoS Pathogens (2012) 8(4) : e1002637

Kaplan-Turkoz B, Jimenez-Soto LF, Dian C, Ertl C, Remaut H, Louche A, Tosi T, Haas R and Terradot L
Structural insights into Helicobacter pylori oncoprotein CagA interaction with beta1 integrin.
Proceedings of the National Academy of Sciences (2012) 109(36) : 14640-14645

Lallemand LA, Zubieta C, Lee SG, Wang Y, Acajjaoui S, Timmins J, McSweeney S, Jez JM, McCarthy JG and McCarthy AA
A structural basis for the biosynthesis of the major chlorogenic acids found in coffee.
Plant Physiology (2012) 160(1) : 249-260

Mädler S, Barylyuk K, Boeri Erba E, Nieckarz R J, Zenobi R
Compelling advantages of negative ion mode detection in high-mass MALDI-MS for the analysis of homomeric protein complexes.
Journal of the American Society for Mass Spectrometry (2012) 23(2) : 213-24

Moe E, Hall DR, Leiros I, Monsen VT, Timmins J and McSweeney S
Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans.
Acta Crystallographica D Biological Crystallography (2012) 68(Pt 6) : 703-712

Nagarajan S, Skoufias DA, Kozielski F and Pae AN
Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors.
Journal of Medicinal Chemistry (2012) 55(6) : 2561-2573

Pellegrino S, Radzimanowski J, de Sanctis D, Boeri Erba E, McSweeney S and Timmins J
Structural and functional characterization of an SMC-like protein RecN : New insights into double-strand break repair.
Structure (2012) 20(12) : 2076-2089

Pellegrino S, de Sanctis D, McSweeney S and Timmins J
Expression, purification and preliminary structural analysis of the coiled-coil domain of Deinococcus radiodurans RecN.
Acta Crystallographica Section F-Structural Biology and Crystallization Communications (2012) 68(2) : 218-221

Petosa C (2012)
Ran In Encyclopedia of Signaling Molecules, édité par Choi S, Springer, pp 1575-1582

Stelter M, Gutsche I, Kapp U, Bazin A, Bajic G, Goret G, Jamin M, Timmins J and Terradot L
Architecture of a dodecameric bacterial replicative helicase.
Structure (2012) 20(3) : 554-564

Publications 2011

Boeri Erba E, Barylyuk K, Yang Y, Zenobi R.
Quantifying protein-protein interactions within noncovalent complexes using electrospray ionization mass spectrometry.
Anal Chem. (2011) In press.

Boeri Erba E, Zenobi R.
Mass spectrometric studies of dissociation constants of non-covalent complexes.
Annu. Rep. Prog. Chem., Sect. C : Phys. Chem. (2011) 107 : 199-228

Cioci G, Terradot L, Dian C, Mueller-Dieckmann C and Leonard G
Crystal structure of HP0721, a novel secreted protein from Helicobacter pylori.
Proteins (2011) 79(5) : 1678-1681

Devesse L, Smirnova I, Lonneborg R, Kapp U, Brzezinski P, Leonard GA and Dian C
Crystal structures of DntR inducer binding domains in complex with salicylate offer insights into the activation of LysR-type transcriptional regulators.
Molecular Microbiology (2011) 81(2) : 354-367

Dian C, Vitale S, Leonard GA, Bahlawane C, Fauquant C, Leduc D, Muller C, de Reuse H, Michaud-Soret I and Terradot L
The structure of the Helicobacter pylori ferric uptake regulator Fur reveals three functional metal binding sites.
Molecular Microbiology (2011) 79(5) : 1260-1275

Garcia-Saez I, Lacroix F, Blot D, Gabel F and Skoufias DA
Structural characterization of HBXIP : The protein that interacts with the anti-apoptotic protein survivin and the oncogenic viral protein HBx.
Journal of Molecular Biology (2011) 405(2) : 331-340

Good JA, Skoufias DA and Kozielski F
Elucidating the functionality of kinesins : an overview of small molecule inhibitors.
Seminars in Cell and Developmental Biology (2011) 22(9) : 935-945

Kozielski F, Riaz T, DeBonis S, Koehler CJ, Kroening M, Panse I, Strozynski M, Donaldson IM and Thiede B
Proteome analysis of microtubule-associated proteins and their interacting partners from mammalian brain.
Amino Acids (2011) 41(2) : 363-385

Langer K, Dian C, Rybin V, Müller CW, Petosa C
Insights into the function of the CRM1 cofactor RanBP3 from the structure of its Ran-binding domain.
PLoS One (2011)6(2) : e17011

Perrakis A, Musacchio A, Cusack S and Petosa C
Investigating a macromolecular complex : The toolkit of methods.
Journal of Structural Biology (2011) 175 (2) : 106-112

Skoufias DA
Is there a "G spot" in sister chromatid cohesion resolution ?
Cell Cycle (2011) 10(17) : 2835

Publications 2010

Marcoux J, Thierry E, Vivès C, Signor L, Fieschi F, Forest E
Investigating alternative acidic proteases for H/D exchange coupled to mass spectrometry : plasmepsin 2 but not plasmepsin 4 is active under quenching conditions.
Journal of the American Society for Mass Spectrometry (2010) 21(1):76-9.

Rousseaux S, Petosa C, Muller CW and Khochbin S
[A novel key element in post-meiotic male genome reprogramming.].
Med. Sciences (Paris) (2010) 26(2) : 130-132

Tcherniuk S, Skoufias DA, Labriere C, Rath O, Gueritte F, Guillou C and Kozielski F
Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor.
Angewandte Chemie International Edition (2010) 49(44) : 8228-8231

Tcherniuk S, van Lis R, Kozielski F, Skoufias DA.
Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines.
Biochem Pharmacol. (2010) 79(6):864-72.

Wollers S, Layer G, Garcia-Serres R, Signor L, Clemancey M, Latour JM, Fontecave M, Ollagnier de Choudens S
Iron-sulfur (Fe-S) cluster assembly : the SufBCD complex is a new type of Fe-S scaffold with a flavin redox cofactor.
Journal of Biological Chemistry (2010) 285(30) : 23331-41

Publications 2009

Behlke-Steinert S, Touat-Todeschini L, Skoufias DA and Margolis RL
SMC5 and MMS21 are required for chromosome cohesion and mitotic progression.
Cell Cycle (2009) 8(14) : 2211-2218

Hans F, Skoufias D A, Dimitrov S and Margolis R L
Molecular distinctions between aurora A and B : A single residue change transforms aurora A into correctly localized and functional aurora B.
Molecular Biology of the Cell (2009) 20(15) : 3491-3502

McDonald CM, Petosa C and Farrell PJ
Interaction of Epstein-Barr virus BZLF1 C-terminal tail structure and core zipper is required for DNA replication but not promoter transactivation.
Journal Of Virology (2009) 83 : 3397-3401

Morinière J, Rousseaux S, Steuerwald U, Soler-López M, Curtet S, Vitte AL, Govin J, Gaucher J, Sadoul K, Hart DJ, Krijgsveld J, Khochbin S, Müller CW and Petosa C
Cooperative binding of two acetylation marks on a histone tail by a
single bromodomain.
Nature (2009) 461 : 664-668

Pires R, Hartlieb B, Signor L, Schoehn G, Lata S, Roessle M, Moriscot C, Popov S, Hinz A, Jamin M, Boyer V, Sadoul R, Forest E, Svergun DI, Göttlinger HG, Weissenhorn W
A crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments.
Structure (2009) 17(6) : 843-56

Popowycz F, Schneider C, DeBonis S, Skoufias DA, Kozielski F, Galmarini CM and Joseph B
Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives.
Bioorganic and Medicinal Chemistry (2009) 17(9) : 3471-3478

Tcherniuk S, van Lis R, Kozielski F and Skoufias DA
Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-l-cysteine in tumor derived cell lines.
Biochemical Pharmacology (2009) 79(6) : 864-872

Wade RH, Garcia-Saez I and Kozielski F
Structural variations in protein superfamilies : actin and tubulin.
Molecular Biotechnology (2009) 42 : 49-60

Publications 2008

Debonis S, Skoufias DA, Indorato RL, Liger F, Marquet B, Laggner C, Joseph B and Kozielski F
Structure-activity relationship of s-trityl-l-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.
Journal of Medicinal Chemistry (2008) 51(5) : 1115-1125

Garcia-Saez I, Docquier JD, Rossolini GM and Dideberg O
The three-dimensional structure of VIM-2, a Zn-[beta]-lactamase from Pseudomonas aeruginosa in its reduced and oxidised form.
Journal of Molecular Biology (2008) 375(3) : 604-611

Karlsson QH, Schelcher C, Verrall E, Petosa C and Sinclair AJ
Methylated DNA recognition during the reversal of epigenetic silencing is regulated by cysteine and serine residues in the Epstein-Barr virus lytic switch protein.
PLoS Pathogens (2008) 4(3) : e1000005

Karlsson QH, Schelcher C, Verrall E, Petosa C and Sinclair AJ
The reversal of epigenetic silencing of the EBV genome is regulated by viral bZIP protein.
Biochemical Society Transactions (2008) 36(Pt 4) : 637-639

Kozielski F, Skoufias DA, Indorato RL, Saoudi Y, Jungblut PR, Hustoft HK, Strozynski M and Thiede B
Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5.
Proteomics (2008) 8(2) : 289-300

Publications 2007

Klein E, DeBonis S, Thiede B, Skoufias DA, Kozielski F and Lebeau L
New chemical tools for investigating human mitotic kinesin Eg5.
Bioorganic & Medicinal Chemistry (2007) 15(19) : 6474-6488

Kozielski F, DeBonis S and Skoufias DA
Screening for inhibitors of microtubule-associated motor proteins.
Methods in Molecular Medicine (2007) 137 : 189-207

Garcia-Saez I, Debonis S, Lopez R, Trucco F, Rousseau B, Thuery P and Kozielski F
Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the (R) configuration.
Journal of Biological Chemistry (2007) 282(13) : 9740-9747

Skoufias DA, Indorato RL, Lacroix F, Panopoulos A and Margolis RL
Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed.
Journal of Cell Biology (2007) 179(4) : 671-685

Publications 2006

Fourest-Lieuvin A, Peris L, Gache V, Garcia-Saez I, Juillan-Binard C, Lantez V and Job D
Microtubule regulation in mitosis : tubulin phosphorylation by the cyclin-dependent kinase Cdk1.
Molecular Biology of the Cell (2006) 17(3) : 1041-50

Garcia-Saez I, Tcherniuk S and Kozielski F
The structure of human neuronal Rab6B in the active and inactive form.
Acta Crystallographica D Biological Crystallography (2006) 62(Pt 7) : 725-33

Garcel A, Gout E, Timmins J, Chroboczek J and Fender P
Protein transduction into human cells by adenovirus dodecahedron using WW domains as universal adaptors. Journal of Gene Medicine (2006) 8(4) : 524-531

Neumann E, Garcia-Saez I, Debonis S, Wade RH, Kozielski F and Conway JF
Human kinetochore-associated kinesin CENP-E visualized at 17 A resolution bound to microtubules.
Journal of Molecular Biology (2006) 362(2) : 203-11

Skoufias DA, Debonis S, Saoudi Y, Lebeau L, Crevel I, Cross R, Wade RH, Hackney D and Kozielski F
S-trityl-l-cysteine is a reversible, tight-binding inhibitor of the human kinesin eg5 that specifically blocks mitotic progression.
Journal of Biological Chemistry (2006) 281 : 17559-17569

Publications 2005

Scrittori L, Skoufias DA, Hans F, Gerson V, Sasson-Corsi P, Dimitrov D and Margolis RL
A small C-terminal sequence of Aurora B is responsible for localization and function
Molecular Biology of the Cell (2005) 16(1) : 292-305

Publications 2004

Andreassen P R, Skoufias D A and Margolis R L
Analysis of the spindle-assembly checkpoint in HeLa cells
Methods in Molecular Biology (2004) 281 : 213-26

Debonis S, Skoufias D A, Lebeau L, Lopez R, Robin G, Margolis R L, Wade R H and Kozielski F
In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities
Molecular Cancer Therapeutics (2004) 3(9) : 1079-1090

Delacour-Larose M, Molla A, Skoufias D A, Margolis R L and Dimitrov D
Distinct dynamics of aurora B and survivin during mitosis
Cell Cycle (2004) 3(11) : 1418-1426

Garcia-Saez I, Blot D, Kahn R and Kozielski F
Crystallization and preliminary crystallographic analysis of the motor domain of human kinetochore-associated protein CENP-E using an automated crystallization procedure.
Acta Crystallographica D Biological Crystallography (2004) 60(Part 6) : 1158-1160

Garcia-Saez I, Yen T, Wade R and Kozielski F
Crystal structure of the motor domain of the human kinetochore protein CENP-E.
Journal of Molecular Biology (2004) 340(5) : 1107 - 16

Skoufias D A, Lacroix F B, Andreassen P R, Wilson L and Margolis R L
Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase
Molecular Cell (2004) 15(6) : 977-990

IBS - Institut de Biologie Structurale - Grenoble / France

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Publications

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