IBS - Institut de Biologie Structurale - Grenoble / France

Group presentation

2025-01-16T16:45:17Z

Group leader: Hugues Nury

The group aims to understand signaling and transport across a biological membrane. To do so, we study membrane proteins at the molecular level with electrophysiology and structural techniques. The membrane transport group comprises four teams:

The Gordeliy lab combines an interest in rhodopsins with the development of in meso crystallization
The Moreau lab develops the Ion Channel-Coupled Receptor technology
The Nury lab focuses on pentameric ligand-gated ion channels

Publications of the group can be found here.

Key words

Ion channels
G-Protein Coupled Receptors
Potassium channel, Kir channel, K-ATP channel
Microorganism rhodopsins
Nucleotide transport
Biosensors
Serotonin 5-HT3 receptor
In meso crystallization
Odorant receptor
Insect receptor
Cryo-EM
Electrophysiology

Specialized techniques

Overexpression (eukaryotic systems mostly) and purification of membrane proteins
Biophysical, biochemical and functional characterizations
Membrane protein crystallization with vapor diffusion and lipidic phase (HTMPC platform)
X-ray crystallography
Cryo-electron microscopy
Construction of mutants, chimeras, and fusion proteins
Heterologous expression in Xenopus oocytes (manual and robotic setups)
Patch-clamp on cells and proteoliposomes
Two-microelectrode voltage clamp (manual and robotic setups)

Group members

AUDIC Guillaume — 2025-01-16T16:25:48Z

The Membrane's group members are:

Photo de groupe 2023 au Pic Saint Michel - Vercors

Permanents members:

BAUD Delphine
DENIAUD Corinne
GORDELIY Valentin
JULIAN-BINARD Céline
MAGNAT Justine
Christophe Moreau
NURY Hugues
NEYTON Jacques
PEBAY-PEYROULA Eva

Temporary researchers:

CASMAN Camille
MARCHAL Estelle

Post-doc:

ASTASHKIN Roman
MINNIBERGER Sonja

PhD:

AUDIC Guillaume
FOULADKAR Farah
LABOURÉ Tatiana
MOREAU Marie

Trainees:

FEUILLET Camille

Publications

2025-01-16T16:25:45Z

Publications since 2014

Our list of publications with peerReviewing, books and book sections since 2014 can be found below (data issued from HAL-IBS).
The display may take 1 to 2 seconds. To check the entire list, use the inner scroll bar.

Publications up to 2013

Our list of publications from 2000 to 2013 is displayed below.

Publications 2013

Büldt G, Gordeliy V, Klare JP, Engelhard M
Sensory Rhodopsin II: Signal Development and Transduction
Encyclopedia of Biophysics (2013): 2312-2315

Gushchin I, Chervakov P, Kuzmichev P, Popov AN, Round E, Borshchevskiy V, Ishchenko A, Petrovskaya L, Chupin V, Dolgikh DA, Arseniev AA, Kirpichnikov M and Gordeliy V
Structural insights into the proton pumping by unusual proteorhodopsin from nonmarine bacteria.
Proceedings of the National Academy of Sciences (2013) 110(31): 12631-12636

Gushchin I, Gordeliy V and Grudinin S
Two distinct states of the HAMP domain from sensory rhodopsin transducer observed in unbiased molecular dynamics simulations.
PLoS One (2013) 8(7): e66917

Ishchenko A, Round E, Borshchevskiy V, Grudinin S, Gushchin I, Klare JP, Balandin T, Remeeva A, Engelhard M, Büldt G and Gordeliy V
Ground state structure of D75N mutant of sensory rhodopsin II in complex with its cognate transducer.
Journal of Photochemistry and Photobiology B: Biology (2013) 123(5): 55-58

Vijayachandran LS, Thimiri Govinda Raj DB, Edelweiss E, Gupta K, Maier J, Gordeliy V, Fitzgerald DJ and Berger I
Gene gymnastics: Synthetic biology for baculovirus expression vector system engineering.
Bioengineered (2013) 4(5): 279-287

Publications 2012

Blesneac I, Ravaud S, Juillan-Binard C, Barret L-A, Zoonens M, Polidori A, Miroux B, Pucci B and Pebay-Peyroula E
Production of UCP1 a membrane protein from the inner mitochondrial membrane using the cell free expression system in the presence of a fluorinated surfactant.
Biochimica et Biophysica Acta (BBA) - Biomembranes (2012) 1818(3): 798-805

Blesneac I, Ravaud S, Machillot P, Zoonens M, Masscheylen S, Miroux B, Vivaudou M and Pebay-Peyroula E
Assaying the proton transport and regulation of UCP1 using solid supported membranes.
European Biophysics Journal (2012) 41(8): 675-679

Deniaud A, Panwara P, Frelet-Barrand A, Bernaudat F, Julian-Binard C, Ebel C, Rolland N and Pebay-Peyroula E
Oligomeric status and nucleotide binding properties of the chloroplast ATP/ADP transporter 1: towards a molecular understanding of the transport mechanism.
PLoS One (2012) 7(3): e32325

Gushchin IY, Gordeliy VI and Grudinin S
A novel dimerization interface of cyclic nucleotide binding domain, which is disrupted in presence of cAMP: implications for CNG channels gating.
Journal of Molecular Modeling (2012) 18(9): 4053-4060

Panwar P, Deniaud A and Pebay-Peyroula E
Contamination from affinity column: Encounter with a new villain in the world of membrane protein crystallization.
Acta Crystallographica D Biological Crystallography (2012) 68(10): 1272-1277

Ravaud S, Bidon-Chanal A, Blesneac I, Machillot P, Juillan-Binard C, Dehez F, Chipot C and Pebay-Peyroula E
Impaired transport of nucleotides in a mitochondrial carrier explains severe human genetic diseases.
ACS Chemical Biology (2012) 7(7): 1164-1169

Publications 2011

Borshchevskiy VI, Round ES, Popov AN, Buldt G and Gordeliy VI
X-ray-radiation-induced changes in bacteriorhodopsin structure.
Journal of Molecular Biology (2011) 409 (5): 813-825

Deniaud A, Bernaudat F, Frelet-Barrand A, Juillan-Binard C, Vernet T, Rolland N and Pebay-Peyroula E
Expression of a chloroplast ATP/ADP transporter in E. coli membranes: Behind the Mistic strategy.
Biochimica and Biophysica Acta - Biomembranes (2011) 1808 (8): 2059-2066

Dupeux F, Rower M, Seroul G, Blot D and Marquez J, A
A thermal stability assay can help to estimate the crystallization likelihood of biological samples.
_ Acta Crystallographica Section D-Biological Crystallography (2011) 67: 915-919

Garcia-Saez I, Lacroix F, Blot D, Gabel F and Skoufias DA
Structural characterization of HBXIP: The protein that interacts with the anti-apoptotic protein survivin and the oncogenic viral protein HBx.
Journal of Molecular Biology (2011) 405(2): 331-340

Gushchin IY, Gordeliy VI and Grudinin S
Role of the HAMP domain region of sensory rhodopsin transducers in signal transduction.
Biochemistry (2011) 50 (4): 574-580

Gushchin I, Reshetnyak A, Borshchevskiy V, Ishchenko A, Round E, Grudinin S, Engelhard M, Büldt G and Gordeliy V
Active state of sensory rhodopsin II: Structural determinants for signal transfer and proton pumping.
Journal of Molecular Biology (2011) 412 (4): 591-600

Ling WL, Biro A, Bally I, Tacnet P, Deniaud A, Doris E, Frachet P, Schoehn G, Pebay-Peyroula E and Arlaud GJ
Proteins of the innate immune system crystallize on carbon nanotubes but are not activated.
ACS Nano (2011) 5 (2): 730-737

Murugova TN, Solodovnikova IM, Yurkov VI, Gordeliy VI, Kuklin AI, Ivankov OI, Kovalev YS, Popov VI, Teplova VV and Yaguzhinsky LS
Potentials of small-angle neutron scattering for studies of the Structure of “Live” Mitochondria”.
Neutron News (2011) 22: 11-14

Solov'ev DV, Kuklin AI, Utrobin PK, Ozerin AN, Kurkin TS, Ivan'kov OI, Bulavin LA and Gordeliy VI
X-ray scattering and volumetric P-V-T studies of the dimyristoylphosphatidylcholine-water system.
Journal of Surface Investigation: X-ray, Synchrotron and Neutron
Techniques (2011) 5(1): 7-10

Publications 2010

Borshchevskiy V, Efremov R, Moiseeva E, Buldt G and Gordeliy V
Overcoming merohedral twinning in crystals of bacteriorhodopsin grown in lipidic mesophase.
Acta Crystallographica D Biological Crystallography (2010) 66(Pt 1): 26-32

Borshchevskiy V, Moiseeva E, Kuklin A, Buldt G, Hato M and Gordeliy V
Isoprenoid-chained lipid beta-XylOC(16+4)-A novel molecule for in meso membrane protein crystallization.
Journal of Crystal Growth (2010) 312(22): 3326-3330

Bulavin LA, Gordeliy VI, Ivan'kov OI, Islamov AK and Kuklin AI
Neutron studies of the NaBr impurity influence on micelle formation in the heay water-tetradecyltrimethylammonium bromide systems.
Ukrainian Journal of Physics (2010) 55(3): 288-292

Deniaud A, Liguori L, Blesneac I, Lenormand JL and Pebay-Peyroula E
Crystallization of the membrane protein hVDAC1 produced in cell-free system.
Biochimica et Biophysica Acta (BBA) - Biomembranes (2010) 1798(8): 1540-1546

Deniaud A, Moiseeva E, Gordeliy V and Pebay-Peyroula E
Crystallography of membrane proteins: from crystallization to structure.
Methods in Molecular Biology (2010) 654: 79-103

Durand D, Vives C, Cannella D, Perez J, Pebay-Peyroula E, Vachette P and Fieschi F
NADPH oxidase activator p67(phox) behaves in solution as a multidomain protein with semi-flexible linkers.
Journal of Structural Biology (2010) 169: 45-53

Falk S, Ravaud S, Koch J and Sinning I
The C terminus of the Alb3 membrane insertase recruits cpSRP43 to the thylakoid membrane.
Journal of Biological Chemistry (2010) 285(8): 5954-5962

Frelet-Barrand A, Boutigny S, Moyet L, Deniaud A, Seigneurin-Berny D, Salvi D, Bernaudat F, Richaud P, Pebay-Peyroula E, Joyard J and Rolland N
Lactococcus lactis, an alternative system for functional expression of peripheral and intrinsic Arabidopsis membrane proteins.
PLoS One (2010) 5(1): e8746

Gushchin IY, Gordeliy VI and Grudinin S
Role of the HAMP Domain Region of Sensory Rhodopsin Transducers in Signal Transduction.
Biochemistry (2010):

Nury H, Blesneac I, Ravaud S and Pebay-Peyroula E
Structural approaches of the mitochondrial carrier family.
Methods in Molecular Biology (2010) 654: 105-117

Radzimanowski J, Ravaud S, Schott A, Strahl S and Sinning I
Cloning, recombinant production, crystallization and preliminary X-ray diffraction analysis of SDF2-like protein from Arabidopsis thaliana.
Acta Crystallographica Section F-Structural Biology and Crystallization Communications (2010) 66(Pt 1): 12-14

Rogachev AV, Kuklin AI, Cherny AY, Ozerin AN, Muzafarov AM, Tatarinova EA and Gordeliy VI
Structure of organosilicon dendrimers of higher generations.
Physics of the Solid State (2010) 52(5): 1045-1049

Publications 2009

Boesecke P, Bois JM, Crepin T, Hunte C, Kahn R, Kao WC, Nauton L, Winther AM, Moller J, Nissen P, Nury H, Olesen C, Pebay-Peyroula E, Vicat J and Stuhrmann H
A first low-resolution difference Fourier map of phosphorus in a membrane protein from near-edge anomalous diffraction.
Journal of Synchrotron Radiation (2009) 16(Pt 5): 658-665

Borel F, de Groot A, Juillan-Binard C, de Rosny E, Laudet V, Pebay-Peyroula E, Fontecilla-Camps JC and Ferrer JL
Crystal structure of the ligand-binding domain of the retinoid X receptor from the ascidian polyandrocarpa misakiensis.
Proteins (2009) 74(2): 538-542

Deniaud A, Goulielmakis A, Coves J and Pebay-Peyroula E
Differences between CusA and AcrB crystallisation highlighted by protein flexibility.
PLoS One (2009) 4(7): e6214

LPM
Gordeliy VI and Moiseeva ES (2009)
In meso approaches to membrane protein crystallization in Molecules: Aggregation, nucleation, crystallization. Beyong medical and other implications, World Scientific Publishing Co 259-281

Krammer EM, Ravaud S, Dehez E, Pebay-Peyroula E and Chipot C
High-chloride concentrations abolish the binding of adenine nucleotides in the mitochondrial ADP/ATP carrier family.
Biophysical Journal (2009) 97(10): L25-L27

Moisseva ES, Reshetnyak AB, Borshchevskiy VI, Baeken C, Büldt G and Gordeliy VI
Comparative analysis of quality of membraine protein bacteriorhodopsin crystals obtained in octylglucoside and octylthioglucoside.
Journal of Surface Investigation. X-ray Synchrotron and Neutron Techniques (2009) 3(1): 29-32

Ravaud S, Robert X, Watzlawick H, Haser R, Mattes R and Aghajari N
Structural determinants of product specificity of sucrose isomerases.
Febs Letters (2009) 583(12): 1964-1968

Publications 2008

Dehez F, Pebay-Peyroula E and Chipot C
Binding of ADP in the mitochondrial ADP/ATP carrier is driven by an electrostatic funnel.
Journal of the American Chemical Society (2008) 130(38): 12725-12733

Gordeliy VI and Moiseeva ES (2008)
Crystallization of membrane proteins in Soft matter: From synthetic to biological materials 2008, édité par Dhont G, Gompper G, Nägele G, Richter D and Winkler RG FZJ Juelich

Nury H, Manon F, Arnou B, le Maire M, Pebay-Peyroula E and Ebel C
Mitochondrial bovine ADP/ATP carrier in detergent is predominantly monomeric but also forms multimeric species (dagger).
Biochemistry (2008) 47(47): 12319-12331

Reshetnyak AB, Borshchevskiy VI, Klare JP, Moiseeva ES, Engelhardt M, Buldt G and Gordeliy VI
Comparative analysis of sensory rhodopsin II structures in complex with a transducer and without It.
Journal of Surface Investigation-X-Ray Synchrotron and Neutron Techniques (2008) 2(6): 894-899

Rogachev AV, Cherny AY, Ozerin AN, Muzafarov AM, ATatarinova E, Islamov AK, Gordeliy VI and Kuklin AI
Revealing inner structure of the polycarbosilane dendrimers from small-angle neutron scattering data.
International Conference on Theoretical Physics 'Dubna-Nano2008' (2008) 129: 51

Uhrikova D, Kucerka N, Teixeira J, Gordeliy V and Balgavy P
Structural changes in dipalmitoylphosphatidylcholine bilayer promoted by Ca2+ ions: a small-angle neutron scattering study.
Chemistry and Physics of Lipids (2008) 155(2): 80-89

Publications 2007

Gorshkova JE and Gordeliy VI
Investigation of the interaction of dimethyl sulfoxide with lipid membranes by small-angle neutron scattering.
Crystallography Reports (2007) 52(3): 535-539

Lacapere JJ, Pebay-Peyroula E, Neumann JM and Etchebest C
Determining membrane protein structures: still a challenge!
Trends in Biochemical Sciences (2007) 32(6): 259-270

Murugova TN, Gordeliy VI, Kuklin AI, Sollodovnikova IM and Yaguzhinsky LS
Study of three-dimensionally ordered structures of intact mitochondria by small-angle neutron scattering.
Crystallography Reports (2007) 52(3): 521-524

Pebay-Peyroula E (2007)
High resolution structures of membrane proteins: From X-ray crystallography to an integrated approach of membrane in Biophysical analysis of membrane proteins. Investigating structure and function, édité par Pebay-Peyroula E John Wiley and Sons, pp. 3-27

Rogachev AV, Cherny AY, Ozerin AN, Gordeliy VI and Kuklin AI
Spherical sector model for describing the experimental small-angle neutron scattering data for dendrimers.
Crystallography Reports (2007) 52(3): 500-504

Publications 2006

Dahout-Gonzalez C, Nury H, Trezeguet V, Lauquin GJ, Pebay-Peyroula E and Brandolin G
Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier.
Physiology (Bethesda) (2006) 21: 242-249

de Rosny E, de Groot A, Jullian-Binard C, Gaillard J, Borel F, Pebay-Peyroula E, Fontecilla-Camps JC and Jouve HM
Drosophila nuclear receptor E75 is a thiolate hemoprotein.
Biochemistry (2006) 45(32): 9727-9734

Durand D, Cannella D, Dubosclard V, Pebay-Peyroula E, Vachette P and Fieschi F
Small-angle X-ray scattering reveals an extended organization for the autoinhibitory resting state of the p47(phox) modular protein.
Biochemistry (2006) 45(23): 7185-7193

Efremov R, Gordeliy VI, Heberle J and Buldt G
Time-resolved microspectroscopy on a single crystal of bacteriorhodopsin reveals lattice-induced differences in the photocycle kinetics.
Biophys J (2006) 91(4): 1441-1451

Fourest-Lieuvin A, Peris L, Gache V, Garcia-Saez I, Juillan-Binard C, Lantez V and Job D
Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.
Molecular Biology of the Cell (2006) 17(3): 1041-1050

Mancheño HJM and Pebay-Peyroula E (2006)
Protein-Lipid Interactions. in New Approaches and Emerging Concepts, édité par Mateo CR, Gómez J, Villalaín J and González Ros JM Springer Verlag Berlin Heidelberg, pp.63-100

Murugova TN, Gordeliy VI, Islamov AK, Kuklin AI, Solodovnikova IM and Yaguzhinsky LS
Detection of new type of membrane structure in mitochondria under low-amplitude swelling by small angle neutron scattering.
Biochimica Et Biophysica Acta-Bioenergetics (2006): 524-525

Nury H, Dahout-Gonzalez C, Trezeguet V, Lauquin GJ, Brandolin G and Pebay-Peyroula E
Relations between structure and function of the mitochondrial ADP/ATP carrier.
Annual Review of Biochemistry (2006) 75: 713-741

Pebay-Peyroula E (2006)
The mitochondrial ADP/ATP carrier in Structural Biology of Membrane Proteins, édité par Grisshammer R and Buchanan S The Royal Society of Chemistry, pp.373-389

Ravaud S, Do Cao MA, Jidenko M, Ebel C, Le Maire M, Jault JM, Di Pietro A, Haser R and Aghajari N
The ABC transporter BmrA from Bacillus subtilis is a functional dimer when in a detergent-solubilized state.
Biochemical Journal (2006) 395(2): 345-353

Biou V, Bosecke P, Bois JM, Brandolin G, Kahn R, Mas C, Nauton L, Nury H, Pebay-Peyroula E, Vicat J and Stuhrmann H
X-ray spectroscopy and X-ray diffraction at wavelengths near the K-absorption edge of phosphorus.
Journal of Synchrotron Radiation (2005) 12(Pt 4): 402-409

de Groot A, de Rosny E, Juillan-Binard C, Ferrer JL, Laudet V, Pierce RJ, Pebay-Peyroula E, Fontecilla-Camps JC and Borel F
Crystal structure of a novel tetrameric complex of agonist-bound ligand-binding domain of Biomphalaria glabrata retinoid X receptor.
Journal of Molecular Biology (2005) 354(4): 841-853

De Marcos Lousa C, Trezeguet V, David C, Postis V, Arnou B, Pebay-Peyroula E, Brandolin G and Lauquin GJ
Valine 181 is critical for the nucleotide exchange activity of human mitochondrial ADP/ATP carriers in yeast.
Biochemistry (2005) 44(11): 4342-4348

Fieulaine S, Juillan-Binard C, Serero A, Dardel F, Giglione C, Meinnel T and Ferrer J-L
The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms.
Journal of Biological Chemistry (2005) 280(51): 42315-42324

Gordeliy VI, Cherezov V and Teixeira J
Strength of thermal undulations of phospholipid membranes.
Phys Rev E Stat Nonlin Soft Matter Phys (2005) 72(6 Pt 1): 061913

Grudinin S, Buldt G, Gordeliy V and Baumgaertner A
Water molecules and hydrogen-bonded networks in bacteriorhodopsin - Molecular dynamics simulations of the ground state and the M-intermediate.
Biophysical Journal (2005) 88(5): 3252-3261

Massenet C, Chenavas S, Cohen-Addad C, Dagher MC, Brandolin G, Pebay-Peyroula E and Fieschi F
Effects of p47phox C-terminus phosphorylations on binding towards p40phox and p67phox : structure and function comparaison of p40phox and p67phox SH3 domains.
Journal of Biological Chemistry (2005) 280(14): 13752-13761

Nury H, Dahout-Gonzalez C, Trezeguet V, Lauquin GJ, Brandolin G and Pebay-Peyroula E
Structural basis for lipid-mediated interactions between mitochondrial ADP/ATP carrier monomers. .
Febs Letters (2005) 579(27): 6031-6036

Publications 2004

Garcia-Saez I, Blot D, Kahn R and Kozielski F
Crystallization and preliminary crystallographic analysis of the motor domain of human kinetochore-associated protein CENP-E using an automated crystallization procedure.
Acta Crystallographica D Biological Crystallography (2004) 60(Part 6): 1158-1160

Girard E, Pebay-Peyroula E, Vicat J and Kahn R
Heavy-atom derivatives in lipidic cubic phases: results on hen egg-white lysozyme tetragonal derivative crystals with Gd-HPDO3A complex.
Acta Crystallographica D Biological Crystallography (2004) 60(Pt 8): 1506 - 1508

Jacquamet L, Ohana J, Joly J, Borel F, Pirocchi M, Charrault P, Bertoni A, Israel-Gouy P, Carpentier P, Kozielski F, Blot D and Ferrer J
Automated analysis of vapor diffusion crystallization drops with an x-ray beam.
Structure (Camb) (2004) 12(7): 1219 - 1225

Pebay-Peyroula E and Brandolin G
Nucleotide exchange in mitochondria: insight at a molecular level.
Current Opinion in Structural Biology (2004) 14(4): 420-425

Serre L, Rossy E, Pebay-Peyroula E, Cohen-Addad C and Coves J
Crystal structure of the oxidized form of the periplasmic mercury-binding protein MerP from Ralstonia metallidurans CH34.
Journal of Molecular Biology (2004) 339(1): 161-171

Publications 2003

Dahout-Gonzalez C, Brandolin G and Pebay-Peyroula E
Crystallization of the bovine ADP/ATP carrier is critically dependent upon the detergent-to-protein ratio.
Acta Crystallographica D Biological Crystallography (2003) 59: 2353-2355

Landau EM, Pebay-Peyroula E and Neutze R
Structural and mechanistic insight from high resolution structures of archaeal rhodopsins.
Febs Letters (2003) 555(1): 51-56

Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trezeguet V, Lauquin GJ-M and Brandolin G
Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside.
Nature (2003) 426(6962): 39-44

Publications 2002

Neutze R, Pebay-Peyroula E, Edman K, Royant A, Navarro J and Landau EM
Bacteriorhodopsin: a high-resolution structural view of vectorial proton transport.
Biochimica and Biophysica Acta - Biomembranes (2002) 1565(2): 144-167.

Pebay-Peyroula E, Royant A, Landau EM and Navarro J
Structural basis for sensory rhodopsin function.
Biochimica and Biophysica Acta - Biomembranes (2002) 1565(2): 196-205.

Royant A, Grizot S, Kahn R, Belrhali H, Fieschi F, Landau EM and Pebay-Peyroula E
Detection and characterization of merohedral twinning in two protein crystals: bacteriorhodopsin and p67phox.
Acta Crystallographica D Biological Crystallography (2002) 58(Pt 5): 784-791.

Publications 2001

Grizot S, Fieschi F, Dagher MC and Pebay-Peyroula E
The active N-terminal region of p67phox: structure at 1.8 A resolution and biochemical characterizations of the A128V mutant implicated in chronic granulomatous disease.
Journal of Biological Chemistry (2001) 276(24): 21627-21631.

Grizot S, Grandvaux N, Fieschi F, Faure J, Massenet C, Andrieu JP, Fuchs A, Vignais PV, Timmins PA, Dagher MC and Pebay-Peyroula E
Small angle neutron scattering and gel filtration analyses of neutrophil NADPH oxidase cytosolic factors highlight the role of the C-terminal end of p47(phox) in the association with p40(phox).
Biochemistry (2001) 40(10): 3127-3133.

Léonard A, Escrive C, Laguerre M, Pebay-Peyroula E, Néri W, Pott T, Katsaras J and Dufourc EJ
Location of cholesterol in DMPC membranes. A comparative study by neutron diffraction and molecular mechanics simulation.
Langmuir (2001) 17: 2019-2030

Pebay-Peyroula E and Rosenbusch JP
High-resolution structures and dynamics of membrane protein-lipid complexes: a critique.
Current Opinion in Structural Biology (2001) 11(4): 427-432.

Royant A, Edman K, Ursby T, Pebay-Peyroula E, Landau EM and Neutze R
Spectroscopic characterization of bacteriorhodopsin's L-intermediate in 3D crystals cooled to 170 K.
Photochemistry and Photobiology (2001) 74(6): 794-804.

Publications 2000

Chiu ML, Nollert P, Loewen MC, Belrhali H, Pebay-Peyroula E, Rosenbusch JP, Landau EM and Neutze R
Crystallization in cubo: general applicability to membrane proteins lipidic cubic phase crystallization of bacteriorhodopsin and cryotrapping of intermediates: towards resolving a revolving photocycle.
Acta Crystallographica D Biological Crystallography (2000) 56(Pt 6): 781-784

Pebay-Peyroula E, Neutze R and Landau EM
Lipidic cubic phase crystallization of bacteriorhodopsin and cryotrapping of intermediates: towards resolving a revolving photocycle.
Biochimica and Biophysica Acta (2000) 1460(1): 119-132

Royant A, Edman K, Ursby T, Pebay-Peyroula E, Landau EM and Neutze R
Helix deformation is coupled to vectorial proton transport in the photocycle of bacteriorhodopsin [see comments].
Nature (2000) 406(6796): 645-648

Theses

2025-01-16T16:25:43Z

All our theses

The list of PhD theses undertaken in the Protein Dynamics and Flexibility by NMR Group can be found year by year below (manuel list).

Theses 2022

Roman Astashkin
Structural studies of cyanobacterial anion pump
Thèse de doctorat soutenue le 24 janvier 2022

Mathilde Folacci
Engineering and characterization of Kir channels and bacterial ligand-gated ion channels
Thèse de doctorat de l'Université Grenoble Alpes, soutenue le 25 mars 2022

Ana Sofia Oliveira
Electrophysiological studies of (1) the regulation of G protein-gated potassium channels by δ-opioid receptors and (2) the function of viral rhodopsins
Thèse de doctorat de l'Université Grenoble Alpes, soutenue le 21 avril 2022

Theses 2019

Zlatomir Todorov
Computational study of the structure-function relationship of Kir3 channels and applications to the design of light-gated Kir3 channels
Thèse de doctorat de la Communauté Université Grenoble Alpes, soutenue le 18 novembre 2019

Lucie Polovinkin
Structural studies of the 5-HT3 receptor
PhD thesis from Universite Grenoble Alpes, defended on October 18, 2019

Simon Harris
Exploiting G protein-coupled receptors : exploring new possibilities for protein-based biosensors
Thèse de doctorat de la Communauté Université Grenoble Alpes, soutenue le 12 décembre 2019

Theses 2018

Laura Lemel
Développement de la technologie des récepteurs couplés à un canal ionique pour la caractérisation fonctionnelle des récepteurs couplés aux protéines G. Thèse de doctorat de l'Université Grenoble Alpes, soutenue le 24 septembre 2018. (Directeur de thèse : Christophe Moreau)

Theses 2016

Anastasya Shilova
Development of serial protein crystallography with synchtrotron radiation. Thèse de doctorat de l'Université de Grenoble, soutenue le Mercredi 21 Décembre 2016

Gina Catalina Reyes Mejia
Etudes moléculaires du canal potassique sensible à l'ATP : gating, pathologie et optogénétique. Thèse de doctorat de l'Université Grenoble Alpes, soutenue le 23 septembre 2016. (Directeur de thèse : Michel Vivaudou)

Aleksandra Woźnicka-Misăilă
An investigation and characterization of different ADP/ATP Carrier homologs. Thèse de doctorat de l'Université de Grenoble, soutenue le 19 septembre 2016

Theses 2015

Yann Huon de Kermadec
Les nanodisques comme outil pour l'étude des protéines membranaires intégrales.
Thèse de doctorat de l'Université Grenoble Alpes, soutenue le 27 novembre 2015.

Maria Antonietta Principalli
Étude structure-fonction du canal Kir6.2 et de son couplage avec des partenaires naturels et artificiels. Thèse de doctorat de l'Université Grenoble Alpes, soutenue le 9 octobre 2015. (Directeurs de thèse : Michel Vivaudou & Jean Revilloud)

Thèses 2014

Marchand Laurène
Etudes fonctionnelle et structurale d'un transporteur d'ADP-ATP chloroplastique. Thèse de doctorat de l'Université Grenoble Alpes, soutenue le 19 septembre 2014.

Maria Silacheva
Heterologous expression of human connexin 43 in Escherichia coli. Thèse de doctorat de l'Université de Grenoble, soutenue le 10 mars 2014.

Chady Nasrallah
Étude du rôle joué par les porines dans la persistance des infections par Providencia stuartii. Thèse de doctorat de l'Université de Grenoble, soutenue le 28 janvier 2014.

Thèses 2013

Katarzyna Niescierowicz
Développement de la technologie Ion Channel-Coupled Receptor pour l'étude structure-fonction des récepteurs couplés aux protéines G et du canal Kir6.2. Thèse de doctorat de l'Université Grenoble Alpes, soutenue le 21 octobre 2013. (Directeurs de thèse : Christophe Moreau & Michel Vivaudou)

Borshchevskiy Valentin
Obtaining high-quality X-ray data of bacteriorhodopsin functional states. Thèse de doctorat de l'Université Joseph Fourier, Grenoble I, soutenue le 08 février 2013.

Remeeva Alina
Development of new approaches for nano volume crystallization of membrane proteins. Thèse de doctorat de l'Université Joseph Fourier, Grenoble I, soutenue le 08 février 2013.

Theses 2012

Moiseeva Vera
Probing the oligomeric organization of the mitochondrial ADP/ATP carrier in native membranes.Thèse de doctorat de l'Université Joseph Fourier, Grenoble I, soutenue le 12 juin 2012.

Panwar Pankaj
Structural and functional studies on nucleotide transporters. Thèse de doctorat de l'Université Joseph Fourier, Grenoble I, soutenue le 26 janvier 2012.

Theses 2010

Lydia Caro
Conception et caractérisation de biocapteurs basés sur l'association de récepteurs et canaux ioniques. Thèse de doctorat de l'Université Joseph Fourier, Grenoble I, soutenue le 30 septembre 2010. (Directeurs de thèse : Michel Vivaudou & Christophe Moreau)

Iulia Blesneac
Structure et fonction de transporteurs mitochondriaux. Thèse de doctorat de l'Université Joseph Fourier, Grenoble I, soutenue le 17 juillet 2010. (Directeurs de thèse : Eva Pebay-Peyroula & Michel Vivaudou)

Theses 2008

Julien Dupuis
Couplage fonctionnel entre un récepteur et un canal ionique : Etude du canal K-ATP et application pour la création de biocapteurs. Thèse de doctorat de l'Université Joseph Fourier, Grenoble I, soutenue le 8 septembre 2008. (Directeurs de thèse : Michel Vivaudou & Jean Revilloud)

Theses 2007

Johanna Karst
Caractérisation d'une protéine de fonction inconnue, YdiB de Bacillus subtilis, membre d'une nouvelle famille d'ATPases exclusivement bactériennes.
Thèse de doctorat de l'Université Joseph Fourier, Grenoble I

Manuelle Quinaud
Etude structurale et fonctionnelle de PscE:PscF:PscG, un hétérotrimère nécessaire à la biogenèse de l'aiguille de sécrétion de type III chez Pseudomonas aeruginosa
Thèse de doctorat de l'Université Joseph Fourier, Grenoble I, soutenue le 25 septembre 2007

Theses 2005

Fabienne Gally
Etude structure/fonction d'une proteine ABC : SUR, le récepteur des sulfonylurées.PhD thesis from Universite Joseph Fourier, Grenoble I, defended on November 15, 2005. (Directeur de thèse : Michel Vivaudou)

Sylvie Chenavas
Etude des interactions entre les facteurs cytosoliques du complexe de la NADPH Oxydase
Thèse de doctorat de l'Université Joseph Fourier, Grenoble I, soutenue le 10 février 2005

Thèses 2004

Virginie Dubosclard
Le complexe de la NADPH oxydase : études structurales des facteurs cytosoliques.
Thèse de doctorat de l'Université Joseph Fourier, Grenoble I, soutenue le 12 juillet 2004

Theses 2003

Anne-Lise Prost
Structure et fonction du transporteur de métaux lourds, YCF1. PhD thesis from Universite Joseph Fourier, Grenoble I, defended on May 16, 2003. (Directeur de thèse : Michel Vivaudou)

Thèses 2002

Hélène Jacquet
Pharmacologie moleculaire d'un transporteur ABC : Le recepteur des sulfonylurees, sous-unite du canal K-ATP. PhD thesis from Universite Joseph Fourier, Grenoble I, defended on September 30, 2002. (Directeur de thèse : Michel Vivaudou)

Christophe Moreau
Les bases moléculaires du mécanisme d'action des ouvreurs potassiques sur les canaux K-ATP. PhD thesis from Universite Joseph Fourier, Grenoble I, defended on March 21, 2002. (Directeur de thèse : Michel Vivaudou)

Theses 2000

Anne-Lise Prost
Caractérisation des sites de liaison de deux ouvreurs potassiques, diazoxide et cromakalim, sur le canal potassique sensible à l'ATP. Pharm.D. thesis from Universite Claude Bernard, Lyon I, defended on June 16, 2000. (Directeur de thèse : Michel Vivaudou)

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Please note that the theses of the last 12 months are not yet available on this site and theses prior to 2010 are not exhaustively listed.

Nury team member

NURY Hugues — 2022-11-18T11:45:22Z

Team Members

Team Members

Permanent members:

BAUD Delphine
DENIAUD Corinne
JULIAN-BINARD Céline
NURY Hugues
PEBAY-PEYROULA Eva

Temporary ingeneer :

MARCHAL Estelle

Post-doctoral fellows :

MINNIBERGER Sonja

Doctoral students :

LABOURÉ Tatiana
FOULADKAR Farah

Interns :

FEUILLER Camille

Valentin Gordeliy Team

GORDELIY Valentin — 2022-11-17T16:51:22Z

Principal investigator: Valentin Gordeliy, Research Director CEA

Staff

– Gordeliy Valentin, DR CEA
– Astashkin Roman, Post-doctorant

Previous members

– Ekaterina Round, Post-doctorante
– Vitaly Polovinkin, Post-doctorant
– Pavel Chervakov
– Alina Remeeva
– Valentin Borshchevskiy
– Evelina Edelweiss
– Maria Silacheva
– Ivan Gushchin
– Petr Utrobin
– Florine Dupeux
– Ekaterina Round, Postdoctoral fellow
– Vitaly Polovinkin, Postdoctoral fellow

Team Members

AUDIC Guillaume — 2022-10-27T16:02:00Z

Christophe MOREAU (DR2 CNRS) .
Justine MAGNAT (AI CNRS) .
Camille CASMAN (IE CNRS) .
Marie MOREAU (PhD Student) .
Apolline PIERRE (PhD Student) .
Guillaume AUDIC (PhD Student) .

ERC NANOZ-ONIC project (2016-2022)

MOREAU Christophe — 2022-10-13T15:17:21Z

NANOZ-ONIC stands for carbon NANOtubes, NOse(Z) and electrONIC.

Synopsis

The project has for ambition to develop an original bioinspired approach for further design of biosensors for non-invasive, painless and real-time detection of volatile biomarkers in exhaled breath of patients. Such biomarkers have been identified for several severe diseases including different cancers, diabetes mellitus and neurodegeneration. A fast, simple and miniaturized breath-diagnostic system has obvious advantages for early detection of these pathologies, for increasing considerably the number of diagnosed persons and for point-of-care monitoring.

While electronic noses (e-noses) already exist for some pathologies like asthma, diagnosing diseases from breath analysis is generally impeded by the lack of one or several technical requirements (sensibility, selectivity, simplicity, versatility…), the ideal technology being analogous to the natural olfactory system.

To meet the challenge of a bio-inspired, two technologies were interfaced in this project: the Ion Channel-Coupled Receptors (ICCR) and the single-walled Carbon NanoTube-Field Effect Transistors (swCNT-FET). ICCR are original biosensors created in the IBS laboratory by linking G Protein Coupled Receptors (GPCRs) to an ion channel. Recognition of compounds by the receptor is transduced into electrical signal by the ion channel. A library of ICCRs with natural olfactory receptors would provide a coveted olfactory map of samples for accurate and multiplexed diagnostics. To detect the electrical signal with extreme sensitivities and in nanoscaled format, ICCRs are integrated in swCNT-FET transistors. The obstacles of ICCR purification, lipid bilayer insertion and stability is overcome by nanovesicles preparation. The detection of odorant with ICCR-swCNT-FET device by project members demonstrated the feasibility of this approach.

Consortium

This project is a partnership between two beneficiaries: Centre National de la Recherche Scientifique (CNRS) and Seoul National University (SNU) and three laboratories: Dr. Moreau, Prof. Park and Prof. Hong.

Major achievements

The work performed during the project was simultaneously focused on three technical aspects: 1) development of receptor-based biosensors for detecting volatile compounds; 2) optimization of the biological material for interfacing the biosensors with carbon nanotube Field-effect transistors (FETs); and 3) improvements of FETs with higher sensitivity, reusability and a surface appropriate to the analysis of gaseous samples.

The results led to the publication of 26 articles and a book chapter and the presentation of the project and results in two joint symposia between the European Federation of Biotechnology and the Asian Federation of Biotechnology.

The main progress obtained to date are:
1) in biosensor engineering:
– The development of a second generation of hybrid receptor/ion channels biosensors with enhanced signal amplitude (Garcia Fernandez et al. Sci Rep. 2021).
– The functional characterization in Xenopus oocytes of optimised human olfactory receptor provided by the laboratory of Professor Matsunami (Duke University, NC, USA) and a fish olfactory receptor.
– The electrophysiological detection of odours with olfactory receptors from other species, widening the diversity of recognized ligands.
– extracellular domains of taste receptors were also successfully used as biosensors demonstrating the feasibility of this approach (Jeong et al. ACS Appl. Mater. Interfaces 2022).

2) in production of biological materials:
– An additional and simpler method to the initial method of nanovesicles preparation from membrane of mammalian cells were developed. Thus, olfactory receptors were produced in bacteria. For their integration in FETs, they were solubilized and stabilized either in nanodiscs (Yang et al. ACS Nano 2017; Lee et al. Sci. Rep. 2018, Lee et al. Biosens. Bioelectron. 2020) or in dual detergent micelles (Shin et al. Sci. Rep. 2020 and Yoo et al. Sens. Actuators B Chem. 2022) for detecting odorants or toxic gas.

3) in upgrading of FETs
– A magnetic biochip was developed to improve the speed and sensitivity of detection (low non-specific binding) and to facilitate the regeneration of the surface (Yoo et al. Nanotechnology 2018).
– A sol-gel matrix was developed on the FET surface to allow the detection of volatile compound (Kim et al. Sci. Rep. 2018)
– The addition of engineered floating electrodes enable the specific, quantitative and high sensitivity detection of compounds (Pham Ba et al. ACS Appl. Mater. Interfaces 2018).
– Hybrid surfaces with carbon nanotube and gold reduced noises and resistivity (Shin et al. Adv. Electron. Mater. 2020).

Publications

1) Nanoscale hybrid systems based on carbon nanotubes for biological sensing and control. Youngtak Cho, Narae Shin, Daesan Kim, Jae Yeol Park, Seunghun Hong. Bioscience Reports. 2017: http://europepmc.org/articles/PMC5483890
2) Magnetically-focusing biochip structures for high-speed active biosensing with improved selectivity. Haneul Yoo, Dong Jun Lee, Daesan Kim, Juhun Park, Xing Chen, Seunghun Hong. Nanotechnology. 2018: http://stacks.iop.org/0957-4484/29/i=26/a=265501?key=crossref.dd40246d6989f553aa032a566086ad5b
3) Nanodisc-Based Bioelectronic Nose Using Olfactory Receptor Produced in Escherichia coli for the Assessment of the Death-Associated Odor Cadaverine. Heehong Yang, Daesan Kim, Jeongsu Kim, Dongseok Moon, Hyun Seok Song, Minju Lee, Seunghun Hong, Tai Hyun Park. ACS Nano. 2016: https://hal.archives-ouvertes.fr/hal-02388831
4) Quantitative electrophysiological monitoring of anti–histamine drug effects on live cells via reusable sensor platforms. Viet Anh Pham Ba, Dong-guk Cho, Daesan Kim, Haneul Yoo, Van-Thao Ta, Seunghun Hong. Biosensors and Bioelectronics. 2017: http://linkinghub.elsevier.com/retrieve/pii/S0956566317302294
5) Human-like smelling of a rose scent using an olfactory receptor nanodisc-based bioelectronic nose. Minju Lee, Heehong Yang, Daesan Kim, Myungjae Yang, Tai Hyun Park, Seunghun Hong. Scientific Reports. 2018: https://www-nature-com.insb.bib.cnrs.fr/articles/s41598-018-32155-1
6) Artificial Rod and Cone Photoreceptors with Human-Like Spectral Sensitivities. Byeongho Park, Heehong Yang, Tai Hwan Ha, Hyun Seo Park, Seung Ja Oh, Yong-Sang Ryu, Youngho Cho, Hyo-Suk Kim, Juyeong Oh, Dong Kyu Lee, Chulki Kim, Taikjin Lee, Minah Seo, Jaebin Choi, Young Min Jhon, Deok Ha Woo, Seok Lee, Seok Hwan Kim, Hyuk-Jae Lee, Seong Chan Jun, Hyun Seok Song, Tai Hyun Park, Jae Hun Kim. Advanced Materials. 2018: https://hal.archives-ouvertes.fr/hal-02187743
7) Nafion-Radical Hybrid Films on Carbon Nanotube Transistors for Monitoring Antipsychotic Drug Effects on Stimulated Dopamine Release. Viet Anh Pham Ba, Dong-guk Cho, Seunghun Hong. ACS Applied Materials & Interfaces. 2019: https://hal.archives-ouvertes.fr/hal-02187852v1
8) Dye-functionalized Sol-gel Matrix on Carbon Nanotubes for Refreshable and Flexible Gas Sensors. Jeongsu Kim, Haneul Yoo, Viet Anh Pham Ba, Narae Shin, Seunghun Hong. Scientific Reports. 2018: http://europepmc.org/articles/PMC6086896
9) High-Speed Lateral Flow Strategy for a Fast Biosensing with an Improved Selectivity and Binding Affinity. Dong Guk Cho, Haneul Yoo, Haein Lee, Yeol Kyo Choi, Minju Lee, Dong June Ahn, Seunghun Hong. Sensors. 2018: https://doaj.org/toc/1424-8220
10) Bioelectronic Nose Using Olfactory Receptor-Embedded Nanodiscs. Heehong Yang, Minju Lee, Daesan Kim, Seunghun Hong, Tai Hyun Park. Olfactory Receptors (book chapter) 2018: https://link.springer.com/protocol/10.1007/978-1-4939-8609-5_18
11) Modified Floating Electrode-Based Sensors for the Quantitative Monitoring of Drug Effects on Cytokine Levels Related with Inflammatory Bowel Diseases. Viet Anh Pham Ba, Yoo Min Han, Youngtak Cho, Taewan Kim, Byung Yang Lee, Joo Sung Kim, Seunghun Hong. ACS Applied Materials & Interfaces. 2018: https://zenodo.org/record/3501799
12) Nanoscale mapping of noise-source-controlled hopping and tunneling conduction in domains of reduced graphene oxide. Shashank Shekhar, Hyungwoo Lee, Duckhyung Cho, Myungjae Yang, Minju Lee, Seunghun Hong. Carbon. 2019: https://hal.archives-ouvertes.fr/hal-02384186
13) Bioelectronic sensor mimicking the human neuroendocrine system for the detection of hypothalamic-pituitary-adrenal axis hormones in human blood. Seung Hwan Lee, Minju Lee, Heehong Yang, Youngtak Cho, Seunghun Hong, Tai Hyun Park. Biosensors and Bioelectronics. 2020: https://www.sciencedirect.com/science/article/pii/S0956566320300683?via%3Dihub
14) Semiconducting Carbon Nanotubes Embedded in a Metallic Film for a Thermistor Device with an Adjustable Temperature Coefficient and Reduced Noise Source Activities. Narae Shin, Youngtak Cho, Jeongsu Kim, Seunghun Hong. Advanced Electronic Materials. 2020: https://onlinelibrary.wiley.com/doi/full/10.1002/aelm.202000073
15) Ion-Selective Carbon Nanotube Field-Effect Transistors for Monitoring Drug Effects on Nicotinic Acetylcholine Receptor Activation in Live Cells. Youngtak Cho, Viet Anh Pham Ba, Jin-Young Jeong, Yoonji Choi, Seunghun Hong. Sensors. 2020: http://europepmc.org/articles/PMC7374424
16) The ligand-bound state of a G protein-coupled receptor stabilizes the interaction of functional cholesterol molecules. Laura Lemel, Katarzyna Nieścierowicz, M. Dolores García-Fernández, Leonardo Darré, Thierry Durroux, Marta Busnelli, Mylène Pezet, Fabrice Rébeillé, Juliette Jouhet, Bernard Mouillac, Carmen Domene, Bice Chini, Vadim Cherezov, Christophe J. Moreau. Journal of Lipid Research. 2021: https://hal.archives-ouvertes.fr/hal-03180171
17) Reusable surface plasmon resonance biosensor chip for the detection of H1N1 influenza virus. Haneul Yoo, Junghyun Shin, Jieun Sim, Hyunmin Cho, Seunghun Hong. Biosensors and Bioelectronics. 2020: https://www.sciencedirect.com/science/article/abs/pii/S0956566320305534?via%3Dihub
18) Micelle-stabilized Olfactory Receptors for a Bioelectronic Nose Detecting Butter Flavors in Real Fermented Alcoholic Beverages. Narae Shin, Seung Hwan Lee, Viet Anh Pham Ba, Tai Hyun Park, Seunghun Hong. Scientific Reports. 2020: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270175/
19) Distinct classes of potassium channels fused to GPCRs as electrical signaling biosensors. M. Dolores García-Fernández; Franck C. Chatelain; Hugues Nury; Anna Moroni; Christophe Moreau. Cell Reports Methods. 2021: https://hal.univ-grenoble-alpes.fr/hal-03518152
20) Mapping the nanoscale effects of charge traps on electrical transport in grain structures of indium tin oxide thin films. Hyesong Jeon; Jeongsu Kim; Shashank Shekhar; Jeehye Park; Seunghun Hong. Nanoscale Advances. 2021: https://doi.org/10.1039/D1NA00175B
21) Olfactory receptor-based CNT-FET sensor for the detection of DMMP as a simulant of sarin. Jin Yoo; Daesan Kim; Heehong Yang; Minju Lee; So-ong Kim; Hwi Jin Ko; Seunghun Hong; Tai Hyun Park. Sensors and Actuators B: Chemical. 2022: https://doi.org/10.1016/j.snb.2021.131188
22) Reusable surface amplified nanobiosensor for the sub PFU/mL level detection of airborne virus. Junghyun Shin; Hyeong Rae Kim; Pan Kee Bae; Haneul Yoo; Jeongsu Kim; Yoon-Ji Choi; Aeyeon Kang; Wan S. Yun; Yong-Beom Shin; Jungho Hwang; Seunghun Hong. Scientific Reports. 2021: https://doaj.org/article/e4963c581313496dafacb7bc6b772d38
23) Nanoscale mapping of wavelength-selective photovoltaic responses in H- and J-aggregates of azo dye-based solar cell films. Shashank Shekhar; Inkyoung Park; Jeongsu Kim; Myungjae Yang; Duckhyung Cho; Seunghun Hong. Journal of Materials Chemistry A. 2020: https://doi.org/10.1039/d0ta07328h
24) Dipolar Noise in Fluorinated Molecular Wires. Mingyu Jung, Shashank Shekhar, Duckhyung Cho, Myungjae Yang, Jeehye Park, Seunghun Hong. Nanomaterials. 2022: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031467/
25) Ultrasensitive Bioelectronic Tongue Based on the Venus Flytrap Domain of a Human Sweet Taste Receptor. Jin-Young Jeong, Yeon Kyung Cha, Sae Ryun Ahn, Junghyun Shin, Yoonji Choi, Tai Hyun Park, Seunghun Hong. ACS Appl Mater Interfaces. 2022: https://hal.archives-ouvertes.fr/hal-03668818
26) Evaluation of site-selective drug effects on GABA receptors using nanovesicle-carbon nanotube hybrid devices. Inkyoung Park, InwooYang, Youngtak Cho, Yoonji Choi, Junghyun Shin, Shashank Shekhar, Seung Hwan Lee, Seunghun Hong. Biosensors and Bioelectronics. 2022: https://hal.archives-ouvertes.fr/hal-03668844
27) Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platform. Christopher Chevillard, Axelle Amen, Solène Besson, Dalil Hannani, Isabelle Bally, Valentin Dettling, Evelyne Gout, Christophe J Moreau, Marlyse Buisson, Salomé Gallet, Daphna Fenel, Emilie Vassal-Stermann, Guy Schoehn, Pascal Poignard, Marie-Claire Dagher, Pascal Fender. Molecular Therapy. 2022: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828441/

IBS - Institut de Biologie Structurale - Grenoble / France

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Valentin Gordeliy Team

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ERC NANOZ-ONIC project (2016-2022)

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Synopsis

Consortium

Major achievements

Publications